Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17

Buchanan, Petra C.; Boylan, Kristin L.M.; Walcheck, Bruce; Heinze, Rachel K.; Geller, Melissa A.; Argenta, Peter A.; Skubitz, Amy P.N.

doi:10.1074/jbc.m116.746859

Cited by 53 publications

(52 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blocking ADAM17 may decrease the inhibitory effects of soluble NKG2D ligands and increase NKG2D binding to its ligands on tumor cells. In addition, ADAM17 has been shown to be overexpressed in cancer cells and cause their release of EGFR ligands and adhesion molecules that promote growth and metastasis . Taken together, blocking ADAM17 activity may impair tumor cell growth and survival in various direct and indirect manners.…”

Section: Adam17 As a Regulatory Checkpoint Of Adcc By Nk Cellsmentioning

confidence: 99%

“…There have been broad efforts to develop ADAM17 inhibitors, with a particular focus on preventing tumor cell growth and spread . Initial efforts were on the development of selective small‐molecule inhibitors.…”

Section: Adam17 As a Regulatory Checkpoint Of Adcc By Nk Cellsmentioning

confidence: 99%

“…In addition, ADAM17 has been shown to be overexpressed in cancer cells and cause their release of EGFR ligands and adhesion molecules that promote growth and metastasis. [72][73][74][75][76] Taken together, blocking ADAM17 activity may impair tumor cell growth and survival in various direct and indirect manners.…”

Section: Adam17 As a Regulatory Checkpoint Of Adcc By Nk Cellsmentioning

confidence: 99%

“…There have been broad efforts to develop ADAM17 inhibitors, 76,77 with a particular focus on preventing tumor cell growth and spread. [72][73][74][75][76] Initial efforts were on the development of selective small-molecule inhibitors. Although early toxicity issues have been addressed by improving their specificity, the small-molecule ADAM17…”

Section: Adam17 As a Regulatory Checkpoint Of Adcc By Nk Cellsmentioning

confidence: 99%

See 3 more Smart Citations

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy

Mishra

Walcheck

2019

Journal of Leukocyte Biology

Self Cite

View full text Add to dashboard Cite

Human NK cell antitumor activities involve Ab‐dependent cell‐mediated cytotoxicity (ADCC), which is a key mechanism of action for several clinically successful tumor‐targeting therapeutic mAbs. Human NK cells exclusively recognize these Abs by the Fcγ receptor CD16A (FcγRIIIA), one of their most potent activating receptors. Unlike other activating receptors on NK cells, CD16A undergoes a rapid down‐regulation in expression by a proteolytic process following NK cell activation with various stimuli. In this review, the role of a disintegrin and metalloproteinase‐17 (ADAM17) in CD16A cleavage and as a regulatory checkpoint is discussed. Several studies have examined the effects of inhibiting ADAM17 or CD16A cleavage directly during NK cell engagement of Ab‐coated tumor cells, which resulted in strengthened Ab tethering, decreased tumor cell detachment, and enhanced CD16A signaling and cytokine production. However, the effects of either manipulation on ADCC have varied between studies, which may be due to dissimilar assays and the contribution of different killing processes by NK cells. Of importance is that NK cells under various circumstances, including in the tumor microenvironment of patients, down‐regulate CD16A and this appears to impair their function. Considerable progress has been made in the development of ADAM17 inhibitors, including human mAbs that have advantages of high specificity and increased half‐life in vivo. These inhibitors may provide a therapeutic means of increasing ADCC potency and/or antitumor cytokine production by NK cells in an immunosuppressive tumor microenvironment, and if used in combination with tumor‐targeting Abs or NK cell‐based adoptive immunotherapies may improve their efficacy.

show abstract

Section: Adam17 As a Regulatory Checkpoint Of Adcc By Nk Cellsmentioning

confidence: 99%

Section: Adam17 As a Regulatory Checkpoint Of Adcc By Nk Cellsmentioning

confidence: 99%

Section: Adam17 As a Regulatory Checkpoint Of Adcc By Nk Cellsmentioning

confidence: 99%

Section: Adam17 As a Regulatory Checkpoint Of Adcc By Nk Cellsmentioning

confidence: 99%

See 2 more Smart Citations

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy

Mishra

Walcheck

2019

Journal of Leukocyte Biology

Self Cite

View full text Add to dashboard Cite

show abstract

“…This can include uncontrolled cellular growth and metastasis (Adorno‐Cruz & Liu, 2019). Indeed, much of what is known about adhesion molecules and cellular function has come from studies in cancer biology (Buchanan et al, 2017; Edwards, Handsley, & Pennington, 2008; Najy, Day, & Day, 2008; Shiomi, Lemaitre, D'Armiento, & Okada, 2010; Sousa, Pereira, & Paredes, 2019; Zadka, Kulus, & Piatek, 2018).…”

Section: Introductionmentioning

confidence: 99%

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

D’Occhio

Campanile

Zicarelli

et al. 2020

Molecular Reproduction Devel

View full text Add to dashboard Cite

Cell–cell adhesion molecules have critically important roles in the early events of reproduction including gamete transport, sperm–oocyte interaction, embryonic development, and implantation. Major adhesion molecules involved in reproduction include cadherins, integrins, and disintegrin and metalloprotease domain‐containing (ADAM) proteins. ADAMs on the surface of sperm adhere to integrins on the oocyte in the initial stages of sperm–oocyte interaction and fusion. Cadherins act in early embryos to organize the inner cell mass and trophectoderm. The trophoblast and uterine endometrial epithelium variously express cadherins, integrins, trophinin, and selectin, which achieve apposition and attachment between the elongating conceptus and uterine epithelium before implantation. An overview of the major cell–cell adhesion molecules is presented and this is followed by examples of how adhesion molecules help shape early reproductive events. The argument is made that a deeper understanding of adhesion molecules and reproduction will inform new strategies that improve embryo survival and increase the efficiency of natural mating and assisted breeding in cattle.

show abstract

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

Rahn

Becker‐Pauly

2021

FEBS Letters

View full text Add to dashboard Cite

Systemic inflammatory disorders (SIDs) comprise a broad range of diseases characterized by dysregulated excessive innate immune responses. Severe forms of SIDs can lead to organ failure and death, and their increasing incidence represents a major issue for the healthcare system. Protease‐mediated ectodomain shedding of cytokines and their receptors represents a central mechanism in the regulation of inflammatory responses. The metalloprotease A disintegrin and metalloproteinase (ADAM) 17 is the best‐characterized ectodomain sheddase capable of releasing TNF‐α and soluble IL‐6 receptor, which are decisive factors of systemic inflammation. Recently, meprin metalloproteases were also identified as IL‐6 receptor sheddases and activators of the pro‐inflammatory cytokines IL‐1β and IL‐18. In different mouse models of SID, particularly those mimicking a sepsis‐like phenotype, ADAM17 and meprins have been found to promote disease progression. In this review, we summarize the role of ADAM10, ADAM17, and meprins in the onset and progression of sepsis and discuss their potential as therapeutic targets.

show abstract

Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17

Cited by 53 publications

References 68 publications

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

Contact Info

Product

Resources

About