Ecto-nucleotidase pathway is altered by different treatments with fluoxetine and nortriptyline

l-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats

“…3B, C and D, respectively). Previous studies have already demonstrated that the enzymes able to hydrolyze extracellular nucleotides can be regulated at the transcriptional level following drug treatment (Vuaden et al 2007;Pedrazza et al 2008;Rico et al 2008). Despite the fact that the semi-quantitative analysis of NTPDase1 expression did not show a significant increase in this parameter in the kidney of L-NAME-treated animals, it is noteworthy that there is a clear tendency towards an increase in the number of mRNA transcripts for this enzyme (P = 0.07) (Fig.…”

Pulsed Light Irradiation Improves Behavioral Outcome in a Rat Model of Chronic Mild Stress

“…The mechanism of TLT for improving behavioral outcome in depressed animals is unknown. Fluoxetine has been shown to modify the activity of ATP hydrolysis in rat hippocampus, which could induce an increase of ATP level 35; while TLT has also been reported to increase ATP production 36. Also, both fluoxetine 37 and TLT 4 have been shown to increase adult neurogenesis in rat models.…”

Purinergic Signaling and Related Biomarkers in Depression

“…Based on the potential effects on depression attributable to the non-selective A1 and A2A receptor antagonist caffeine, the role of adenosine in depression has attracted attention. It has been shown that fluoxetine and nortriptyline may affect the ectonucleotidase pathway in synaptosomes, suggesting that antidepressants could modulate the extracellular adenosine levels, which would result in increased adenosine in cerebral cortex and decreased in hippocampus [31]. On the other hand, it seems that chronic treatment with mood stabilizers, such as lithium, used for bipolar disorder and mania, can modulate the ectonucleotidase pathway in hippocampal synaptosomes, with a related decrease of ATP and increase of adenosine levels [32].…”