Ect-Chlorpromazine and Chlorpromazine Compared in the Treatment of Schizophrenia

ECT/chlorpromazine combination versus chlorpromazine alone in acutely schizophrenic patients.

“…It seems that a maximal response may be obtained with 500 mg CPZ and thus concurrent ECT has no synergistic effect at that level. In this respect, the present study is in conflict with the results of both Childers (1964) and Smith et al (1967). They used 1000 mg and 400 mg respectively of chlorpromazine in combination with ECT and found it to be better than chlorpromazine alone.…”

Evidências da eficácia da eletroconvulsoterapia na prática psiquiátrica

“…[95][96][97] Some studies, however, suggest that the combination of ECT and neuroleptics in this population results in a faster recovery than the isolate use of neuroleptics. 98,99 Former studies with acute schizophrenic patients did not show differences between ECT and simulated ECT. 100,101 We should then say that the ECT has a smaller impact on the treatment of non-selected populations of schizophrenic patients, but it continues to be worth in the second line treatment of those patients.…”

Predictive indices for chlorpromazine therapy in schizophrenics.

“…Smith et al (1967) have shown that ECT-chlorpromazine combination to be better than CPZ alone in the treatment of schizophrenia, but Taylor (1980) was of the opinion that the use of ECT alone was superior to the combination of ECT and neuroleptics. These two studies with ECT might have involved a heterogeneous group of patients with different reponsiveness to these treatments.…”