Ecotoxicological analysis of nostocyclamide, a modified cyclic hexapeptide from Nostoc

Todorova, Albena K.; Jüttner, Friedrich

doi:10.2216/i0031-8884-35-6s-183.1

Cited by 26 publications

(17 citation statements)

References 11 publications

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“…The production of allelopathic compounds has already been observed in a wide variety of phytoplankton species (Gleason et al 1986;Gromov et al 1991;Gross et al 1991;Todorova and Juttner 1996;Juttner et al 2001). Despite their initial low abundance, organisms capable of producing allelopathic compounds may become dominant (von Elert and Juttner 1997).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of growth and photosynthesis of the dinoflagellate Peridinium gatunense by Microcystis sp. (cyanobacteria): A novel allelopathic mechanism

Sukenik

Eshkol

Livne

et al. 2002

Limnology & Oceanography

173

100

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We describe a novel allelopathic interaction whereby the cyanobacterium Microcystis sp. inhibits photosynthesis in the freshwater dinoflagellate Peridinium gatunense by abolishing its internal carbonic anhydrase activity. Our analysis indicated a positive correlation between the winter presence of Microcystis and the timing of the annual spring bloom of Peridinium in Lake Kinneret (Sea of Galilee, Israel). Microcystis severely inhibited the growth of Peridinium in mixed laboratory cultures. This was attributed to the excretion of allelopathic substances rather than to successful competition for nutrients. Microcystis-free spent medium (MFSM) inhibited steady-state photosynthesis of Peridinium, as indicated by the reduced rate of oxygen evolution and by a suppressed fluorescence signal. Boosting the inorganic carbon concentration to 25 mmol L Ϫ1 , i.e., 10-fold higher than essential to saturate photosynthesis in the absence of MFSM, partially restored the photosynthetic capacity. MFSM-treated Peridinium cells accumulated a larger internal inorganic carbon pool concomitantly with reduced accumulation of photosynthetic products. The MFSM slowed the hydration rate of CO 2 (assessed from the rate of 18 O exchange between 13 C 18 O 2 and water), indicating that the activity of an internal carbonic anhydrase was severely depressed. Although the nature of the active component in the MFSM that inhibits CA activity has yet to be identified, the ecological consequences of its excretion to the water body are emerging as a potent allelopathic substance that may control the development of phytoplankton competitors. We propose that its allelopathic activity could control the fate and succession of the P. gatunense bloom in Lake Kinneret.

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Section: Discussionmentioning

confidence: 99%

Inhibition of growth and photosynthesis of the dinoflagellate Peridinium gatunense by Microcystis sp. (cyanobacteria): A novel allelopathic mechanism

Sukenik

Eshkol

Livne

et al. 2002

Limnology & Oceanography

173

100

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“…97 A series of bioassays confirmed that 33 inhibited the growth of cyanobacteria, diatoms, and chlorophytes, but not that of the fungus Saccharomyces cerevisiae nor heterotrophic bacteria. 97, 98 Interestingly, 33 was also moderately toxic to Brachionus calyciflorus . Since this freshwater rotifer feeds on cyanobacteria, 99 compound 33 may actually serve more than one distinct ecological functions.…”

Section: Ecological Roles Played By Cyanobacterial Metabolitesmentioning

confidence: 99%

The chemical ecology of cyanobacteria

et al. 2012

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This review covers the literature on the chemically mediated ecology of cyanobacteria, including ultraviolet radiation protection, feeding-deterrence, allelopathy, resource competition, and signalling. To highlight the chemical and biological diversity of this group of organisms, evolutionary and chemotaxonomical studies are presented. Several technologically relevant aspects of cyanobacterial chemical ecology are also discussed.

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“…On the other side, freshwater and terrestrial Nostoc may produce also cytotoxins and other bioactive compounds (e.g. Trimurtulu et al 1995;Todorova and Juttner 1996). Recently, a novel cyclic peptide (nostophycin) was identified from a toxic Nostoc sp.…”

Section: Introductionmentioning

confidence: 99%

Identification and quantification of microcystins from a Nostoc muscorum bloom occurring in Oukaïmeden River (High-Atlas mountains of Marrakech, Morocco)

Oudra¹,

Andaloussi

Vasconcelos

2008

Environ Monit Assess

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Health risks generated by cyanobacterial toxins in drinking and recreational waters are clearly recognised. During the monitoring programme on the distribution of toxic freshwater cyanobacteria in various water bodies including reservoirs, ponds and rivers of Morocco, many toxigenic cyanobacteria bloom-forming species have been identified. Particular attention was given to the investigation of the toxicology of a benthic Nostoc species-Nostoc muscorum Ag. (cyanobacteria, Nostocales, Nostocaceae)-that was found dominant in Oukaïmeden river located at 2,600 m of altitude in High-Atlas mountains of Marrakech. The massive growth of the mat-forming N. muscorum occurred yearly during the period of March-October, when the water temperature was above 10 degrees C. During 1997-1999, samples were collected from either floating or benthic mats. Hepatotoxicity associated to gastrointestinal (diarrhoea) intoxication symptoms was confirmed by intraperitoneal (i.p.) injection in mice of N. muscorum thallus extract. The survival time was estimated to be from 2-5 h, and the calculated i.p. LD(50) in mice ranged from 15 to 125 mg kg(-1) body weight. The application of the high performance liquid chromatography with photodiode array detection confirmed the occurrence of microcystin-LR (MC-LR) and three others microcystin variants from the methanolic Nostoc extract. The MC-LR represented a proportion of 39% of the total microcystin content however, the total concentration equivalents-eq-of MC-LR was estimated to be 139 microg MC-LR eq per gram dry weight. The existence of a benthic microcystin-producing N. muscorum strain under the particular environmental conditions of Oukaïmeden region may be a potential human health hazard and the ecological harmful effects of these cyanobacterial toxins need to be assessed. This paper constitutes the first report of the occurrence of a toxic benthic Nostoc in Morocco. So, the benthic species should be considered during monitoring of toxic Cyanobacteria particularly for river used for source of drinking water.

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Ecotoxicological analysis of nostocyclamide, a modified cyclic hexapeptide from Nostoc

Cited by 26 publications

References 11 publications

Inhibition of growth and photosynthesis of the dinoflagellate Peridinium gatunense by Microcystis sp. (cyanobacteria): A novel allelopathic mechanism

Inhibition of growth and photosynthesis of the dinoflagellate Peridinium gatunense by Microcystis sp. (cyanobacteria): A novel allelopathic mechanism

The chemical ecology of cyanobacteria

Identification and quantification of microcystins from a Nostoc muscorum bloom occurring in Oukaïmeden River (High-Atlas mountains of Marrakech, Morocco)

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