Ecotoxicity of raw and treated effluents generated by a veterinary pharmaceutical company: a comparison of the sensitivities of different standardized tests

Maselli, Bianca de S.; Luna, Luis Augusto Visani de; Palmeira, Joice de O.; Tavares, Karla Palmieri; Barbosa, Sandro; Beijo, Luiz Alberto; Umbuzeiro, Gisela de Aragão; Kummrow, Fábio

doi:10.1007/s10646-015-1425-9

Cited by 20 publications

(8 citation statements)

References 49 publications

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“…Several recent studies have demonstrated the sensitivity of the genus Daphnia in the evaluation of effluent ecotoxicity before and after secondary and tertiary treatments. Maselli et al (2015) compared the sensitivity of different bioassays standardized to raw and treated effluents generated by a veterinary pharmaceutical company. The acute toxicity test with Daphnia similis proved to be the most sensitive for raw and treated effluents.…”

Section: Ecotoxicity Assessmentmentioning

confidence: 99%

“…Recent studies have shown that pharmaceuticals in wastewater, even at trace levels, display toxicity to different organisms, both before and after secondary treatment. Maselli et al (2015) evaluated the ecotoxicity of raw and treated effluents generated by a veterinary pharmaceutical company and compared the sensitivities of different bioassays. The acute toxicity test with D. similis proved to be the most sensitive for raw and treated effluents.…”

Section: Ecotoxicity Assessmentmentioning

confidence: 99%

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Ecotoxicity evaluation of a WWTP effluent treated by solar photo-Fenton at neutral pH in a raceway pond reactor

Freitas

Rivas

Campos-Mañas

et al. 2016

Environ Sci Pollut Res

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Some pollutants can be resistant to wastewater treatment, hence becoming a risk to aquatic and terrestrial biota even at the very low concentrations (ng L-μg L) they are commonly found at. Tertiary treatments are used for micropollutant removal but little is known about the ecotoxicity of the treated effluent. In this study, a municipal secondary effluent was treated by a solar photo-Fenton reactor at initial neutral pH in a raceway pond reactor, and ecotoxicity was evaluated before and after micropollutant removal. Thirty-nine micropollutants were identified in the secondary effluent, mainly pharmaceuticals, with a total concentration of ≈80 μg L. After treatment, 99 % microcontaminant degradation was reached. As for ecotoxicity reduction, the assayed organisms showed the following sensitivity levels: Tetrahymena thermophila > Daphnia magna > Lactuca sativa > Spirodela polyrhiza ≈ Vibrio fischeri. The initial effluent showed an inhibitory effect of 40 % for T. thermophila and 20 % for D. magna. After 20 min of photo-Fenton treatment, no toxic effect was observed for T. thermophila and toxicity dropped to 5 % for D. magna. Graphical abstract Ecotoxicity removal by solar photo-Fenton at neutral pH. ᅟ.

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Section: Ecotoxicity Assessmentmentioning

confidence: 99%

Section: Ecotoxicity Assessmentmentioning

confidence: 99%

Ecotoxicity evaluation of a WWTP effluent treated by solar photo-Fenton at neutral pH in a raceway pond reactor

Freitas

Rivas

Campos-Mañas

et al. 2016

Environ Sci Pollut Res

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show abstract

“…Although A. fischeri is more sensitive to TDF than the other organisms in this study, other researchers have obtained different results. Maselli et al (2015) [50] compared the sensitivities of different ecotoxicity tests for crude and treated effluents from the pharmaceutical industry and found that the crustacean Daphnia similis and the microalga Raphidocelis subcapitata were more sensitive as indicators of toxicity than A. fischeri. The same observation was made by Minagh et al (2009) [51] regarding the toxicity of sertraline to A. fischeri and Daphnia magna, with the latter being the more sensitive species.…”

Section: Toxicity Of Tdf To a Fischerimentioning

confidence: 99%

Toxicity for Aquatic Organisms of Antiretroviral Tenofovir Disoproxil

Silva¹,

Barbosa²,

Mol³

et al. 2019

JEP

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Tenofovir disoproxil fumarate is a prodrug, i.e. inative substance converted in vivo, after absorption to the active form de-esterified tenofovir, which acts as an inhibitor of viral reverse transcriptase. To better understand the toxic effects of these drugs in the environment, three organisms were tested, the effective concentration (EC 50 ) and inhibitory concentration (IC 50 ) of tenofovir disoproxil that resulted in 50% growth inhibition of Microcystis novacekii, 50% immobilization of Artemia salina, and 50% loss of bioluminescence of Aliivibrio fischeri were evaluated. The EC 50 value after 96 h of treatment for the cyanobacterium was 161.01 (156.81 -165.21) mg·L −1 ; the IC 50 value for A. salina after 24 h of treatment was 111.82 (103.18 -120.45) mg·L −1 ; and the IC 50 at 15 min for A. fischeri was 14.83 (13.87 -15.79) mg·L −1 . The test organism most sensitive to the drug was A. fischeri, indicating the importance of using representative models at different trophic levels to assess the potential risk of drugs for environmental toxicity. These results highlight the possible effect of tenofovir disoproxil on decomposer organisms, which may contribute to the environmental persistence of this drug.

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“…In view of toxicity observed, authors recommended that pharmaceutical companies should treat effluents before being discharged into water bodies. Maselli et al (2015) compared the sensitivities of five ecotoxicity tests using aquatic and terrestrial organisms including A. cepa test to evaluate the toxicity of effluents from the production of veterinary medicines before and after treatment. Raw and chemically treated effluent samples were highly toxic.…”

Section: Pharmaceutical Pesticides and Herbicidesmentioning

confidence: 99%

Bioassays based on higher plants as excellent dosimeters for ecotoxicity monitoring: A review

Int¹,

Iqbal²

2019

Preprint

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All sorts of pollution on the planet can be traced back to development of industries and the most important among them is water pollution. Clean technologies, management practices and regular monitoring of effluents could be helpful to minimize the contamination of watersheds. Allium cepa (A. cepa) has been recognized as a promising genetic model to detect the toxicity of industrial wastewater, contaminated soil, river water, nuclear contamination and even for those systems which are considered non toxic. A. cepa is distinguished as a low cost test, easy to handle and sensitive to both in vivo and in vitro models. It offers the detection of damages in genetic material quantitatively and the results can be generalized for other biological and ecological systems. Moreover, the pollutants can be classified on the basis of this test present in industrial effluents and their mechanism of action on genetic material. This review focuses on the studies undertaken to evaluate the toxicity of industrial wastewater, contaminated river and soils.

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Ecotoxicity of raw and treated effluents generated by a veterinary pharmaceutical company: a comparison of the sensitivities of different standardized tests

Cited by 20 publications

References 49 publications

Ecotoxicity evaluation of a WWTP effluent treated by solar photo-Fenton at neutral pH in a raceway pond reactor

Ecotoxicity evaluation of a WWTP effluent treated by solar photo-Fenton at neutral pH in a raceway pond reactor

Toxicity for Aquatic Organisms of Antiretroviral Tenofovir Disoproxil

Bioassays based on higher plants as excellent dosimeters for ecotoxicity monitoring: A review

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