Ecosystems supporting clusters of sporadic TSEs demonstrate excesses of the radical-generating divalent cation manganese and deficiencies of antioxidant co factors Cu, Se, Fe, Zn

Purdey, Mark

doi:10.1054/mehy.1999.0836

Cited by 97 publications

(53 citation statements)

References 123 publications

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“…A link between TSEs and trace metals in soils (e.g. Purdey 2000) has also been suggested, and this has prompted the investigation reported in this paper.…”

Section: Introductionmentioning

confidence: 82%

Spatial correlation between the prevalence of transmissible spongiform diseases and British soil geochemistry

Imrie

Korre

Muñoz‐Meléndez

2008

Environ Geochem Health

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Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurological conditions affecting a number of mammals, including sheep and goats (scrapie), cows (BSE), and humans (Creutzfeldt-Jakob disease). The diseases are widely believed to be caused by the misfolding of the normal prion protein to a pathological isoform, which is thought to act as an infectious agent. Outbreaks of the disease are commonly attributed to contaminated feed and genetic susceptibility. However, the implication of copper and manganese in the pathology of the disease, and its apparent geographical clustering, have prompted suggestions of a link with trace elements in the environment. Nevertheless, studies of soils at regional scales have failed to provide evidence of an environmental risk factor. This study uses geostatistical techniques to investigate the correlations between the distribution of TSE prevalence and soil geochemical variables across the UK according to different spatial scales. A similar spatial pattern in scrapie and BSE occurrence is identified, which may be linked with increasing pH and total organic carbon, and decreasing iodine concentration. However, the pattern also resembles that of the density of dairy farming. Nevertheless, despite the low spatial resolution of the TSE data available for this study, the fact that significant correlations are detected indicates there is a possibility of a link between soil geochemistry, scrapie, and BSE. It is suggested that further investigations of the prevalence of TSE and environmental exposure to trace metals should take into account the factors affecting their bioavailability.

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“…A link between TSEs and trace metals in soils (e.g. Purdey 2000) has also been suggested, and this has prompted the investigation reported in this paper.…”

Section: Introductionmentioning

confidence: 82%

Spatial correlation between the prevalence of transmissible spongiform diseases and British soil geochemistry

Imrie

Korre

Muñoz‐Meléndez

2008

Environ Geochem Health

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“…Metal ion occupancy may instead stabilize PrP Sc molecules, delaying their clearance from cells. Such a mechanism might account for the observation that PrP Sc molecules immunopurified from Creutzfeldt-Jakob disease brains contain aberrantly high levels of manganese and zinc (63) as well as observations that correlate environmental transition metal levels with prion disease (64).…”

Section: Fig 4 Protease Resistance Of Native and Truncated Prpmentioning

confidence: 99%

Ionic Strength and Transition Metals Control PrPSc Protease Resistance and Conversion-inducing Activity

Nishina¹,

Jenks²,

Supattapone

2004

Journal of Biological Chemistry

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“…Pattison and Jebbett (13) noticed more than 30 years ago the similarity between prion histopathology to the histopathology induced by a copper chelator, cuprizone. The incidence of chronic Wasting disease (CWD), a sporadic prion disease of deer and elk, was observed to be higher in regions where the soil had a low copper content (14). Therefore, prion diseases may be related to an alteration of copper transport and a loss of copper-enzyme activities.…”

mentioning

confidence: 99%

Expression of Prion Protein Increases Cellular Copper Binding and Antioxidant Enzyme Activities but Not Copper Delivery

Rachidi¹,

Vilette²,

Guiraud³

et al. 2003

Journal of Biological Chemistry

182

165

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Ecosystems supporting clusters of sporadic TSEs demonstrate excesses of the radical-generating divalent cation manganese and deficiencies of antioxidant co factors Cu, Se, Fe, Zn

Cited by 97 publications

References 123 publications

Spatial correlation between the prevalence of transmissible spongiform diseases and British soil geochemistry

Spatial correlation between the prevalence of transmissible spongiform diseases and British soil geochemistry

Ionic Strength and Transition Metals Control PrPSc Protease Resistance and Conversion-inducing Activity

Expression of Prion Protein Increases Cellular Copper Binding and Antioxidant Enzyme Activities but Not Copper Delivery

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