Ecosystems of invasion and metastasis in mammary morphogenesis and cancer

Mareel, Marc; Santos, Susana Constantino Rosa

doi:10.1387/ijdb.113386mm

Cited by 17 publications

(8 citation statements)

References 154 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumor invasion is the rate-limiting process for metastasis during which fibroblasts and macrophages in the microenvironment actively communicate with tumor cells . Many lines of evidence indicate that inflammation and cytokines regulation are involved in cancer progression . Tumor necrosis factor (TNF)-α is a pro-inflammatory cytokine that plays a critical role in tumor malignancy, including tumor cell motility, invasion, and metastasis .…”

Section: Introductionmentioning

confidence: 99%

Daidzein Suppresses Tumor Necrosis Factor-α Induced Migration and Invasion by Inhibiting Hedgehog/Gli1 Signaling in Human Breast Cancer Cells

Bao

Namgung

Lee

et al. 2014

J. Agric. Food Chem.

View full text Add to dashboard Cite

In breast cancer, the cytokine tumor necrosis factor-α (TNF-α) induces cell invasion, although the molecular basis of it has not been clearly elucidated. In this study, we investigated the role of daidzein in regulating TNF-α induced cell invasion and the underlying molecular mechanisms. Daidzein inhibited TNF-α induced cellular migration and invasion in estrogen receptor (ER) negative MCF10DCIS.com human breast cancer cells. TNF-α activated Hedgehog (Hh) signaling by enhancing Gli1 nuclear translocation and transcriptional activity, which resulted in increased invasiveness; these effects were blocked by daidzein and the Hh signaling inhibitors, cyclopamine and vismodegib. Moreover, these compounds suppressed TNF-α induced matrix metalloproteinase (MMP)-9 mRNA expression and activity. Taken together, mammary tumor cell invasiveness was stimulated by TNF-α induced activation of Hh signaling; these effects were abrogated by daidzein, which suppressed Gli1 activation, thereby inhibiting migration and invasion.

show abstract

Section: Introductionmentioning

confidence: 99%

Daidzein Suppresses Tumor Necrosis Factor-α Induced Migration and Invasion by Inhibiting Hedgehog/Gli1 Signaling in Human Breast Cancer Cells

Bao

Namgung

Lee

et al. 2014

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…However, working with a selected population presents serious disadvantages that are important to keep in mind. In a tumor, in contrast to in vitro models, cells are not only heterogeneous, but they are immersed in diverse ecosystems and communicate with other cell compartments where many signals could participate determining the tumor phenotype and cancer progression [35]. …”

Section: Discussionmentioning

confidence: 99%

Selection of a MCF-7 Breast Cancer Cell Subpopulation with High Sensitivity to IL-1β: Characterization of and Correlation between Morphological and Molecular Changes Leading to Increased Invasiveness

Pérez-Yépez

Ayala-Sumuano

Reveles-Espinoza

et al. 2012

International Journal of Breast Cancer

View full text Add to dashboard Cite

Cancer and inflammation are closely related in tumor malignancy prognosis. Breast cancer MCF-7 cells have a poor invasive phenotype, although, under IL-1β stimulus, acquire invasive features. Cell response heterogeneity has precluded precise evaluation of the malignant transition. MCF-7A3 cells were selected for high sensitivity to IL-1β stimulus, uniform expression of CXCR4, and stability of IL1-RI. Structural changes, colony formation ability, proliferation rate, chemotaxis, Matrigel invasion, E-cadherin mRNA expression and protein localization were determined in these cells and in MCF-7 parental cells under the stimulus of IL-1β. Selected MCF-7A3 cells showed a uniform response to IL-1β stimulation increasing features of invasive cells such as scattering, colony formation, proliferation, chemokinesis and invasion. Basal expression of E-cadherin mRNA was higher, and IL-1β stimulus had no further effect at early times of cytokine exposure. Total E-cadherin levels remained unchanged in parental cells, whereas levels decreased, as MCF-7A3 cells became fibroblastoid or scattered. Triton X-100 soluble/insoluble E-cadherin ratios were highly increased in these cells, while, in MCF-7pl cells, ratios could not be correlated with morphology changes. MCF-7A3 cells uniform response to IL-1β allowed characterization of changes induced by the cytokine that had not been assessed when using heterogeneous cell lines.

show abstract

“…An encounter with Marc De Brabander (1943-2011, working at Janssen Pharmaceutica in Beerse, Belgium, brought microtubule inhibitors into the laboratory as powerful inhibitors of invasion (Mareel and De Brabander, 1978). Translation into therapy was, however, hampered by the fact that antiinvasive doses of these drugs were also cytotoxic.…”

Section: You Mentioned Your Special Interest In the Effects Of Ionizimentioning

confidence: 99%

“…To summarize, I think that we have contributed some valuable pieces to the puzzle, though the question when, why and how cancer does metastasize remains unanswered. My actual way of thinking about this problem follows the ecosystem concept (Mareel and Constantino, 2011).…”

Section: You Mentioned Your Special Interest In the Effects Of Ionizimentioning

confidence: 99%

From the laboratory to the patient and back - an interview with Marc Mareel

Bracke¹

2011

Int. J. Dev. Biol.

View full text Add to dashboard Cite

Ecosystems of invasion and metastasis in mammary morphogenesis and cancer

Cited by 17 publications

References 154 publications

Daidzein Suppresses Tumor Necrosis Factor-α Induced Migration and Invasion by Inhibiting Hedgehog/Gli1 Signaling in Human Breast Cancer Cells

Daidzein Suppresses Tumor Necrosis Factor-α Induced Migration and Invasion by Inhibiting Hedgehog/Gli1 Signaling in Human Breast Cancer Cells

Selection of a MCF-7 Breast Cancer Cell Subpopulation with High Sensitivity to IL-1β: Characterization of and Correlation between Morphological and Molecular Changes Leading to Increased Invasiveness

From the laboratory to the patient and back - an interview with Marc Mareel

Contact Info

Product

Resources

About