Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut

Abstract

Taurine-respiring gut bacteria produce H2S with ambivalent impact on host health. We report the isolation and ecophysiological characterization of a taurine-respiring mouse gut bacterium. Taurinivorans muris strain LT0009 represents a new widespread species that differs from the human gut sulfidogen Bilophila wadsworthia in its sulfur metabolism pathways and host distribution. T. muris specializes in taurine respiration in vivo, seemingly unaffected by mouse diet and genotype, but is dependent on other bacteria for release of taurine from bile acids. Colonization of T. muris in gnotobiotic mice increased deconjugation of taurine-conjugated bile acids and transcriptional activity of a sulfur metabolism gene-encoding prophage in other commensals, and slightly decreased the abundance of Salmonella enterica, which showed reduced expression of galactonate catabolism genes. Re-analysis of metagenome data from a previous study further suggested that T. muris can contribute to protection against pathogens by the commensal mouse gut microbiota. Together, we show the realized physiological niche of a key murine gut sulfidogen and its interactions with selected gut microbiota members.

Inference of Causal Interaction Networks of Gut Microbiota Using Transfer Entropy

“…Many studies has shed light on the profound impact the gut microbiota on human health [1][2][3][4][5][6][7][8][9]. They assist in the digestion and fermentation of the food, enabling the extraction and synthesis of vital nutrients and energy from the food we consume [5,6].…”

“…They assist in the digestion and fermentation of the food, enabling the extraction and synthesis of vital nutrients and energy from the food we consume [5,6]. Beyond their role in nutrition, these microbial communities serve to protect against pathogens [7,8], regulate immune function, and strengthen the biochemical barriers of the gut and intestine [9].…”

Silica Nanoparticle-Based FRET System for Hydrogen Sulfide Detection in Biological and Food Samples

“…13,14 Therefore, the role of hydrogen sulfide in both biomedical and food safety domains is complex and significant. 15,16 Monitoring its levels is crucial for the early diagnosis of diseases and ensuring the quality of food products. 17−19 In the realm of H 2 S detection, significant challenges hinder the accuracy and efficacy of current methods, particularly due to the low H 2 S concentrations in early stage diseases and food spoilage.…”

“…Hydrogen sulfide (H 2 S), a key endogenous gasotransmitter, plays a pivotal role in the realms of biomedical science and food safety. − H 2 S can regulate vascular functions, including vasodilation and blood pressure control, directly impacting cardiovascular health . Its role in mitigating diseases like hypertension, atherosclerosis, and myocardial infarction is underscored by its ability to modulate endothelial cell functions, offering cardioprotective effects. − In the nervous system, H 2 S exhibits neuroprotective properties, such as antioxidation and anti-inflammation, playing a key role in the progression of neurodegenerative diseases like Alzheimer’s and Parkinson’s by influencing neural cell survival and functionality. , In food safety, H 2 S detection is vital for identifying spoilage and potential health hazards, as it is a byproduct of microbial metabolism under anaerobic conditions. − The presence of H 2 S can indicate spoilage and, in some cases, the growth of harmful bacteria like Salmonella , thus serving as a critical marker for food quality and safety. , Therefore, the role of hydrogen sulfide in both biomedical and food safety domains is complex and significant. , Monitoring its levels is crucial for the early diagnosis of diseases and ensuring the quality of food products. − …”

Microbiota of the sulfur cycle in an extremely contaminated Technosol undergoing pedogenesis: A culture-dependent and metagenomic approach

“…At least five compounds between the most oxidized (sulfate) and the most reduced (sulfide) sulfur state – elemental sulfur, polysulfides, thiosulfate, tetrathionate, and sulfite – can be oxidized, reduced or disproportionated by at least one distinct group of microorganisms, with many overlapping groups also capable of these processes. Recently, microbes liberating and reducing sulfite moiety from organosulfonates were also recognized in the context of dissimilatory sulfur metabolism (Hausmann et al, 2018; Peck et al, 2019; Ye et al, 2023). The diversity of taxa oxidizing sulfide or reducing sulfate is even bigger.…”