The Peptic Ulcer (PU) social epidemic comprises one tenth of adult population of the globe. The PU polygenic nature required development of the synergetic bio-psycho-socio-spiritual conception that allowed to specify three prenosological fractals: predisposition - ulcerogenic family, latent - ulcerogenic diathesis, initial - a preulcerous state, and three nosological fractals: a full-scale clinical picture, chronization and an outcome. There have been proposed criteria of a social PU epidemic, a destructive social epidemic and a pandemy. The multidisciplinary program of preventive-correctional and medical-rehabilitation aid has been grounded.