Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications

Dsouza, Roshan; Won, Jungeun; Monroy, Guillermo L.; Spillman, Darold R.; Boppart, Stephen A.

doi:10.1117/1.jbo.23.9.096003

Cited by 20 publications

(21 citation statements)

References 43 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high-resolution OCT system for translational middle ear imaging was developed, based upon a previously developed low-cost briefcase system [ 31 ]. A schematic diagram of the briefcase system is shown in Figure 1 .…”

Section: Methodsmentioning

confidence: 99%

“…First, portable OCT systems have historically been bulky and expensive compared to the standard middle ear diagnostic tools, as a complete system contains a light source, a detector, associated optics, a computer or processing unit and a screen. Recently, a compact, low-cost OCT system (~$8000 USD) with a reasonable system performance (an axial resolution of 8 µm with a 10 kHz A-scan rate) was developed [ 31 ]. Due to the design goals of the imaging system to reduce cost, it had a limited imaging depth and optical power that made difficult to quickly focus the light on a thin TM using a handheld probe in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections

et al. 2021

Self Cite

View full text Add to dashboard Cite

A middle ear infection is a prevalent inflammatory disease most common in the pediatric population, and its financial burden remains substantial. Current diagnostic methods are highly subjective, relying on visual cues gathered by an otoscope. To address this shortcoming, optical coherence tomography (OCT) has been integrated into a handheld imaging probe. This system can non-invasively and quantitatively assess middle ear effusions and identify the presence of bacterial biofilms in the middle ear cavity during ear infections. Furthermore, the complete OCT system is housed in a standard briefcase to maximize its portability as a diagnostic device. Nonetheless, interpreting OCT images of the middle ear more often requires expertise in OCT as well as middle ear infections, making it difficult for an untrained user to operate the system as an accurate stand-alone diagnostic tool in clinical settings. Here, we present a briefcase OCT system implemented with a real-time machine learning platform for middle ear infections. A random forest-based classifier can categorize images based on the presence of middle ear effusions and biofilms. This study demonstrates that our briefcase OCT system coupled with machine learning can provide user-invariant classification results of middle ear conditions, which may greatly improve the utility of this technology for the diagnosis and management of middle ear infections.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…By using Eqs. (1) and (2), the relation between the resulting optical delay of the reference beam and its incident position on the CCD camera, i.e., AE, can be estimated for different values of the radius of curvature of the cylindrical mirror and is shown in Fig. 2(b).…”

Section: Analysis Of Optical Delaymentioning

confidence: 99%

“…Optical coherence tomography (OCT) has become one of the rapidly emerging optical imaging techniques for clinical applications in the past decades [1,2]. On the other hand, in the development of compact devices, requirements such as simple design and operation without mechanical motion are needed to be implemented [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Two dimensional non-scanning transform-free spatial-domain optical coherence tomography

Lin

Chang

Hsu

2019

Biomed. Opt. Express

View full text Add to dashboard Cite

A novel optical coherence tomography system that can perform scanless two dimensional imaging without Fourier transform is proposed and demonstrated. In the system, a convex cylindrical mirror generates an extended spatial distribution of optical delay in the reference arm and a cylindrical lens is used to form a focused line beam in the sample arm. A charge-coupled device camera captures the two dimensional tomographic image of a sample in a snapshot manner. Due to its simple configuration and operation, the system is suitable for developing a compact device for tomographic imaging and measurement.

show abstract

“…Various approaches have been used for developing software engines and graphic user interfaces (GUIs) for SD-OCT or SS-OCT. As a visual programming language, LabVIEW (National Instruments (NI), USA) offers a fast learning curve for developing the application engine [6,7]. However, the image processing speed of LabVIEW is limited even with dynamic link libraries (DLLs).…”

Section: Introductionmentioning

confidence: 99%

A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations

et al. 2020

View full text Add to dashboard Cite

Fourier-domain optical coherence tomography (FD-OCT), including spectral-domain OCT (SD-OCT) and swept-source OCT (SS-OCT), allows the volumetric imaging of the tissue architecture with a faster speed and higher detection sensitivity than does time-domain OCT. Although the hardware implementations of SD-OCT and SS-OCT are different, these technologies share very similar signal processing steps for image reconstruction. In this study, we developed hardware implementations and software architectures to design a generic framework for FD-OCT. For SD-OCT systems, an external synchronization approach was used to realize a data acquisition schematic similar to that used in SS-OCT by carefully managing the timing clocks in the detection unit and for the waveform generation. In addition, by utilizing modules and factory concepts, a software engine can be developed that supports various acquisition devices and software operations or image processing functions with high operation flexibility while maintaining its robustness. Data processing and data saving were optimized using the parallel computing method with the OpenMP library and by leveraging the parallelism within the acquired data, respectively.

show abstract

Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications

Cited by 20 publications

References 43 publications

Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections

Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections

Two dimensional non-scanning transform-free spatial-domain optical coherence tomography

A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations

Contact Info

Product

Resources

About