Economic value of using partially hydrolysed infant formula for risk reduction of atopic dermatitis in high-risk, not exclusively breastfed infants in Singapore

Botteman, Marc; Bhanegaonkar, Abhijeet; Horodniceanu, Erica; Ji, Xiang; Lee, Bee Wah; Bever, Hugo P. Van; Detzel, Patrick

doi:10.11622/smedj.2017113

Cited by 6 publications

(4 citation statements)

References 43 publications

(87 reference statements)

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“…Incorporating WPH into infant formula is particularly beneficial for preventing and managing allergic reactions, which may potentially reduce healthcare costs for consumers and governments, as evidenced by statistical data from Botteman et al. (2018). This aspect emphasizes the health and economic benefits of adding WPH into infant nutrition.…”

Section: Optimizing the Application Of Wphs In Infant Formulas: Chall...mentioning

confidence: 99%

Whey protein hydrolysates and infant formulas: Effects on physicochemical and biological properties

Li,

Zhu

2024

Comp Rev Food Sci Food Safe

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Whey protein hydrolysates are recognized for their substantial functional and biological properties. Their high digestibility and amino acid composition make them a valuable ingredient to hydrolyzed whey infant formulas, enhancing both product functionality and nutritional values for infant growth. It is important to understand the functional and biological properties of whey protein hydrolysates for their applications in infant formula systems. This review explored preparation methods of whey protein hydrolysates for infant formula‐based applications. The effects of whey protein hydrolysate on the physicochemical and biological properties of hydrolyzed whey infant formulas were summarized. The influences of whey protein hydrolysates on the functional and nutritional properties of formulas from manufacturing to infant consumption were discussed. Whey protein hydrolysates are crucial components in the preparation of infant formula, tailored to meet the functional and nutritional demands of the product. The selection of enzyme types and hydrolysis parameters is decisive for obtaining “optimal” whey protein hydrolysates that match the intended characteristics. “Optimal” whey protein hydrolysates offer diverse functionalities, including solubility, emulsification and production stability to hydrolyzed whey infant formulas during manufacturing processes and formulations. They simultaneously promote protein digestibility, infant growth and other potential health benefits, including reduced allergenic potential, as supported by in vitro, in vivo and clinical trials. Overall, the precise selection of enzymes and hydrolysis parameters in the production of whey protein hydrolysates is crucial in achieving the desired characteristics and functional benefits for hydrolyzed whey infant formulas, making them critical in the development of infant nutrition products.

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Section: Optimizing the Application Of Wphs In Infant Formulas: Chall...mentioning

confidence: 99%

Whey protein hydrolysates and infant formulas: Effects on physicochemical and biological properties

Li,

Zhu

2024

Comp Rev Food Sci Food Safe

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“…This is reflected in more than 4000 original research papers focused on gut microbiota and allergy prevention. The gastrointestinal tract plays an important immune function in developing either effector or tolerant responses by balancing the activities of Th1 and Th2 cells as well as regulating Th17 and T regulatory cells in the lamina propria (11). It is thought, that a reduced gut microbial diversity and dysbiosis may affect this balance and lead to a Th2-skewed immune response, with enhanced IgE responses to food antigens, and/or a defect in mounting proper regulatory T-cell responses (2).…”

Section: Role Of Pre-and Probiotics In Allergy Preventionmentioning

confidence: 99%

“…Atopic dermatitis, often linked to food allergies such as CMA, is the most common allergic manifestation in infants and young children, and therefore its occurrence is often the main criterion for evaluation of efficacy of clinical trials aimed at reducing allergy burden in infancy (3). Nutritional intervention soon after birth with a partially hydrolyzed formula (pHF) instead of formula with intact protein was reported to reduce the cumulative J o u r n a l P r e -p r o o f 6 incidence of atopic dermatitis up to 16 years of age and, as a consequence, also to reduce health care costs for healthy, high-risk, non-exclusively breastfed infants (11). In keeping with this, pHFs have been positioned by infant formula manufacturers for the prevention of allergic disease for both primary and secondary prevention (5) in the absence of breastfeeding or in addition to breastfeeding if needed in infants at risk of allergy.…”

Section: Introductionmentioning

confidence: 99%

The role of milk feeds and other dietary supplementary interventions in preventing allergic disease in infants: Fact or fiction?

et al. 2021

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“…Over two-thirds of these deaths are often related to inappropriate feeding practices, happen in the first year of life (12,13,14). EDHS 2016 declared as only 60% of children are introduced to solid foods at 6-8 months, 11% of the infants begin foods before 6 months of age (11).…”

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confidence: 99%

Initiation time of weaning and associated factors among mothers of children aged less than 2 years in Aksum town, Tigray, Ethiopia: A cross sectional study, July 2018

Knfu

Kasa

Msgna

et al. 2019

Preprint

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Background: Weaning is the period of time when infants introduce food different from breast milk in their diet, together with a gradual reduction of the intake of milk. It is estimated that 6% of under-five child mortality every year can be reduced through age appropriate infant feeding. Ethiopian demographic health survey 2016 declared that 21% of children consuming foods by age 4-5 months. Few Studies done in Ethiopia describe initiation time of weaning. Objective: To assess initiation time of weaning and associated factors among mothers of children aged less than 2 years in Aksum Town 2017/18. Methods: Community based cross-sectional study was conducted from December to May 2017/18 among 358 mothers of children. Simple random sampling technique was used to select from the five kebeles. Data was entered to Epi info version 7 and transported to SPSS version 22. Logistic regressions were used to identify the predictors of initiation time of weaning. Variables with P value <0.05 with 95% CI in the multivariable analysis were taken for declaring level of significance. The analyzed data were presented using texts, tables, graphs and charts. Result: In this study prevalence of early initiation of weaning was 38% (CI=33.0, 43.0). Mothers of children aged less than 2 years having poor knowledge on initiation of weaning Adjusted Odds Ratio ((AOR) =2.08, 95% CI=1.12, 3.90), mothers who were not received formal advice from health professionals on initiation of weaning (AOR =1.93, 95% CI=1.17, 3.16), mothers who return to work during post postpartum period (AOR= 3.32, CI=1.99, 5.54) and had family size of four and above (AOR= 2.53 ,95% CI=1.46, 4.39) were significantly associated factors with early initiation time of weaning. Conclusion: In this study prevalence of early initiation of weaning was high. Having poor knowledge, not received formal weaning advice, return to work and have family size of four and above were significantly associated factors with early initiation of weaning. Hence, Formal weaning advice should be given to mothers of children at health institutions during their prenatal care service regarding to initiation time of weaning. Key words: Initiation of weaning, early weaning, timely weaning

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Economic value of using partially hydrolysed infant formula for risk reduction of atopic dermatitis in high-risk, not exclusively breastfed infants in Singapore

Abstract: Introduction: Previous trials have demonstrated reductions in atopic dermatitis (AD)

Cited by 6 publications

References 43 publications

Whey protein hydrolysates and infant formulas: Effects on physicochemical and biological properties

Whey protein hydrolysates and infant formulas: Effects on physicochemical and biological properties

The role of milk feeds and other dietary supplementary interventions in preventing allergic disease in infants: Fact or fiction?

Initiation time of weaning and associated factors among mothers of children aged less than 2 years in Aksum town, Tigray, Ethiopia: A cross sectional study, July 2018

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