Economic Impact Of A 13-Valent Pneumococcal Conjugate Vaccination Programme In A Mexican Corporate Setting

Huicochea-Bartelt, J.L.; Muciño-Ortega, E.; Vargas-Valencia, J

doi:10.1016/j.jval.2014.03.1612

Cited by 1 publication

(4 citation statements)

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“…The most commonly captured benefit from the broad perspective was outcome-related productivity gains. Sixteen studies (10.7%) included this benefit [ 74 – 76 , 81 , 85 , 87 , 98 , 108 , 115 , 117 , 127 , 132 , 142 , 144 , 157 , 165 ]. These studies estimated how much work individuals miss due to a case of pneumococcal disease and compute the value of that missed work by multiplying missed time by the wage rate.…”

Section: Resultsmentioning

confidence: 99%

“…Even within the literature that examines benefits other than our narrow ones, study quality and reporting are at times limited. For example, of the 17 unique studies that account for at least one broad benefit, seven (41.2%) present only study abstracts [ 75 , 81 , 85 , 87 , 98 , 115 , 144 ]. Of the remaining 10 studies [ 74 , 76 , 108 , 117 , 127 , 132 , 142 , 157 , 160 , 165 ], other limitations abound, including, for example, borrowing epidemiological trend data from other countries [ 108 ], lack of data necessitating many assumptions and low estimate precision [ 157 ], and possible confounding due to a study’s observational nature [ 160 ].…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, three economic modeling studies—two from Brazil and one from Mexico—took an employer’s perspective to analyze the effects of vaccinating employees against pneumococcal disease on outcome-related productivity gains [ 81 , 85 , 98 ]. While the three studies presented only abstracts, and are therefore inconclusive by themselves, their findings unanimously favored the benefits of adult pneumococcal vaccination.…”

Section: Resultsmentioning

confidence: 99%

“…In general, the 32 (21.3%) studies that present an analysis of PCV13 alone tend to take a more economically focused approach than the other included studies. Twenty-seven (84.4%) of these PCV13-only studies account for healthcare cost savings [ 55 , 63 , 64 , 80 , 82 , 87 , 91 , 98 , 110 , 117 , 123 , 127 , 128 , 130 – 132 , 150 , 151 , 153 , 156 – 158 , 168 , 173 , 178 , 184 , 194 ], compared with 79 (52.7%) of all included studies. Similarly, seven of these studies (21.9%) account for outcome-related productivity gains [ 81 , 87 , 98 , 117 , 127 , 132 , 157 ], which represents double the share of all included studies (10.7%).…”

Section: Resultsmentioning

confidence: 99%

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The full benefits of adult pneumococcal vaccination: A systematic review

et al. 2017

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BackgroundPneumococcal disease causes substantial morbidity and mortality, including among adults. Adult pneumococcal vaccines help to prevent these burdens, but they are underused. Accounting for the full benefits of adult pneumococcal vaccination may promote more rational resource allocation decisions with respect to adult pneumococcal vaccines.ObjectivesUsing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic review to assess the extent to which the literature has empirically captured (e.g., through measurement or modeling) the full benefits of adult pneumococcal vaccination.MethodsWe systematically searched PubMed and Embase to identify studies published between January 1, 2010 and April 10, 2016 that examine adult pneumococcal vaccination. We included articles if they captured any health or economic benefit of an adult pneumococcal vaccine administered to adults age ≥ 50 or ≥ 18 in risk groups. Finally, we summarized the literature by categorizing the types of benefits captured, the perspective taken, and the strength of the evidence presented. Our protocol is number 42016038335 in the PROSPERO International prospective register of systematic reviews.ResultsWe identified 5,857 papers and included 150 studies for analysis. While most capture health gains and healthcare cost savings, far fewer studies consider additional benefit categories, such as productivity gains. However, the studies with a broader approach still exhibit significant limitations; for example, many present only abstracts, while others offer no new measurements. Studies that examine the 13-valent pneumococcal conjugate vaccine focus more on broad economic benefits, but still have limitations.ConclusionsThis review highlights the need for more robust empirical accounting of the full benefits of adult pneumococcal vaccination. Literature outside this realm indicates that these broad benefits may be substantial. Failing to investigate the full benefits may lead society to undervalue vaccines' contributions and therefore underinvest in their development and adoption.

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