Economic evaluation of HIV pre-exposure prophylaxis strategies: protocol for a methodological systematic review and quantitative synthesis

Thavorn, Kednapa; Kugathasan, Howsikan; Tan, Darrell H. S.; Moqueet, Nasheed; Baral, Stefan; Skidmore, Becky; MacFadden, Derek R.; Simkin, Anna; Mishra, Sharmistha

doi:10.1186/s13643-018-0710-0

Cited by 1 publication

(2 citation statements)

References 36 publications

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“…As with primary cost studies, activities like implementation research to inform decision‐making, target setting, awareness raising, technical assistance, and health information system strengthening—vital and catalytic investments in the early phase of introducing new products into the public health system—were not included. Our findings corroborate other reviews examining PrEP cost and cost‐effectiveness in mathematical modelling studies [23, 66–79]. Case et al.…”

Section: Discussionsupporting

confidence: 91%

“…As with primary cost studies, activities like implementation research to inform decision-making, target setting, awareness raising, technical assistance, and health information system strengthening-vital and catalytic investments in the early phase of introducing new products into the public health system-were not included. Our findings corroborate other reviews examining PrEP cost and cost-effectiveness in mathematical modelling studies [23,[66][67][68][69][70][71][72][73][74][75][76][77][78][79]. Case et al highlighted in a 2019 review the outdated assumptions in the modelling literature, the lack of "real-world costing" and the limitation of the modelling studies to include programme implementation, among other factors [23].…”

Section: Table 7 Economic Analysis Features and Analytic Approaches O...supporting

confidence: 88%

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Implementation and resource needs for long‐acting PrEP in low‐ and middle‐income countries: a scoping review

Castor,

Heck,

Quigee

et al. 2023

J Int AIDS Soc.

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Introduction Several low‐ and middle‐income countries (LMICs) are preparing to introduce long‐acting pre‐exposure prophylaxis (LAP). Amid multiple pre‐exposure prophylaxis (PrEP) options and constrained funding, decision‐makers could benefit from systematic implementation planning and aligned costs. We reviewed national costed implementation plans (CIPs) to describe relevant implementation inputs and activities (domains) for informing the costed rollout of LAP. We assessed how primary costing evidence aligned with those domains. Methods We conducted a rapid review of CIPs for oral PrEP and family planning (FP) to develop a consensus of implementation domains, and a scoping review across nine electronic databases for publications on PrEP costing in LMICs between January 2010 and June 2022. We extracted cost data and assessed alignment with the implementation domains and the Global Health Costing Consortium principles. Results We identified 15 implementation domains from four national PrEP plans and FP‐CIP template; only six were in all sources. We included 66 full‐text manuscripts, 10 reported LAP, 13 (20%) were primary cost studies‐representing seven countries, and none of the 13 included LAP. The 13 primary cost studies included PrEP commodities (n = 12), human resources (n = 11), indirect costs (n = 11), other commodities (n = 10), demand creation (n = 9) and counselling (n = 9). Few studies costed integration into non‐HIV services (n = 5), above site costs (n = 3), supply chains and logistics (n = 3) or policy and planning (n = 2), and none included the costs of target setting, health information system adaptations or implementation research. Cost units and outcomes were variable (e.g. average per person‐year). Discussion LAP planning will require updating HIV prevention policies, technical assistance for logistical and clinical support, expanding beyond HIV platforms, setting PrEP achievement targets overall and disaggregated by method, extensive supply chain and logistics planning and support, as well as updating health information systems to monitor multiple PrEP methods with different visit schedules. The 15 implementation domains were variable in reviewed studies. PrEP primary cost and budget data are necessary for new product introduction and should match implementation plans with financing. Conclusions As PrEP services expand to include LAP, decision‐makers need a framework, tools and a process to support countries in planning the systematic rollout and costing for LAP.

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Section: Discussionsupporting

confidence: 91%

Section: Table 7 Economic Analysis Features and Analytic Approaches O...supporting

confidence: 88%

Implementation and resource needs for long‐acting PrEP in low‐ and middle‐income countries: a scoping review

Castor,

Heck,

Quigee

et al. 2023

J Int AIDS Soc.

View full text Add to dashboard Cite

show abstract

Economic evaluation of HIV pre-exposure prophylaxis strategies: protocol for a methodological systematic review and quantitative synthesis

Cited by 1 publication

References 36 publications

Implementation and resource needs for long‐acting PrEP in low‐ and middle‐income countries: a scoping review

Implementation and resource needs for long‐acting PrEP in low‐ and middle‐income countries: a scoping review

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