Agroforestry systems have become increasingly relevant in recent days as they introduced new commercial opportunities to smallholder farmers. In the same vein, being an eco-friendly practice has gained agroforestry systems popularity as a climate-smart agriculture practice. However, exploiting the investment potential of agroforestry systems requires understanding their challenges and opportunities as a business. The review addresses the combination of annual crops with trees to ensure stable income, social, and environmental justice. In a nutshell, by creating a productive, resilient, and low-emission land-use for smallholder farmers, agroforestry systems can be an effective and efficient pathway towards climate-smart agribusiness and to the achievement of the Global Goal of Sustainable Development.