Application of fluoride solutions, gels, varnishes, and prophylaxis pastes is reviewed as well as the sequential APF/SnF2 office-rinse method. The most widely-used technique is with 1.23% APF gel (12,300 ppm F) in trays. Clinical results from this method are similar to those achieved with an APF solution of the same fluoride concentration. A professional APF gel/tray application need not be preceded by a prophylaxis, should last four min, and should not be followed by a water rinse for 30 min. Fluoride varnishes are newer topical fluoride agents, but their relative efficacy, compared with other proven caries-inhibitory methods, remains to be fully determined. In general, fluoride prophylaxis pastes have not been shown to inhibit caries; however, their use is justified by the ability of some to replenish fluoride lost from the abrasive action of the paste on tooth enamel. The sequential office-rinse method has not been tested in randomized clinical trials, and its use cannot be recommended.