Economic damage of risk factors associated with morbidity and mortality from major chronic non-communicable diseases in Russia in 2016

Kontsevaya, А. V.; Муканеева, Д. К.; Мырзаматова, А. О.; Balanova, Yu. A.; Khudyakov, M. B.; Drapkina, О. М.

doi:10.15829/1728-8800-2020-1-2396

Cited by 20 publications

(15 citation statements)

References 16 publications

(16 reference statements)

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“…Риск развития сердечно-сосудистых заболеваний (CCЗ) тесно связан с образом жизни человека и, прежде всего, с поведенческими факторами риска, из которых значительный вклад в преждевременную смертность населения России вносит курение (13,0%) [1].…”

Section: Introductionunclassified

Association of Smoking with Indicators of the Structure and Function of Blood Vessels in Middle-aged Men

Isaykina¹,

Розанов²,

Александров³

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study the association of smoking with indicators of the structure and function of blood vessels in a sample of middle-aged men.Material and methods. This study is part of a 32-year prospective cohort observation of males starting in childhood (11-12 years). The study included 301 (30.0%) representatives of the original population sample aged 41-44 years. The examination included a survey on a standard questionnaire with an assessment of the status and intensity of smoking, of anthropometric indicators, blood pressure (BP), and determination of the blood lipid spectrum. The stiffness of the arterial wall and central pressure were measured by the method of applanation tonometry. The carotid intima-media thickness of the common carotid artery (C-IMT) was estimated by the method of ultrasonic duplex scanning of the main vessels of the neck.Results. Of the 301 men examined, aged 41-44 years, 92 (30.6%) people never smoked, 73 (24.3%) smoked in the past and 136 (45.2%) people currently smoke. Former smokers were divided by the intensity of smoking in the past as follows: less than 20 cigarettes/day were smoked by 41 (56.0%) people, and ≥20 cigarettes/day - 32 (44.0%) people. Among current smokers, less than 20 cigarettes/day were smoked by 63 (46.0%) people, and ≥20 cigarettes - 73 (54.0%) people. Current smokers have a statistically significantly higher level of triglycerides and lower cholesterol of high density lipoproteins in the blood, augmentation index (AIx), augmentation blood pressure and C-IMT thicker than non-smokers. The thickness of the C-IMT and AIx was statistically significantly greater among current smokers who smoked 20 or more cigarettes daily. Men who smoked in the past had significantly greater body weight, waist circumference and pulse wave velocity. 12.4% of AIx variability was attributable to current smoking combined with variability in alcohol consumption, blood glucose, and heart rate. The body mass index (BMI) and ethanol consumption are independent determinants of peripheral and central systolic pressure, and account for 17.8% and 18.6% of their variance, respectively. The combined contribution of current smoking, age, BMI, low-density lipoprotein cholesterol and plasma glucose to the thickness variability of C-IMT was 13.7%. Among men with a smoking duration in the past >10 years, the levels of total cholesterol, triglycerides and arterial stiffness indicators - AIx, pulse pressure amplification were higher compared to peers with a shorter smoking duration.Conclusion. Current smoking is associated with atherogenic changes in the blood lipid spectrum, impaired structure and function of the main arteries. Moreover, the severity of structural and functional disorders of the arteries is associated with the intensity of current smoking. If you give up smoking, there is a potential possibility of reversibility of these vascular disorders.

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Section: Introductionunclassified

Association of Smoking with Indicators of the Structure and Function of Blood Vessels in Middle-aged Men

Isaykina¹,

Розанов²,

Александров³

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…Уровень смертности зависит от множества факторов: экономических, социальных, окружающей среды, образа жизни, уровня образования и т.д. [3][4][5][6].…”

Section: Introductionunclassified

Malignant neoplasms mortality rates in Moscow and Saint Petersburg in 2015 and 2018

Samorodskaya¹,

Самородская²,

Semenov

et al. 2020

J. Mod. Onco.

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Significant differences in mortality rates of the most of the death causes were detected between Moscow and Saint-Petersburg in the number of researches. Aim.Comparison and ranging of standardized mortality rates (SMR) from malignant neoplasms (MN) of different localizations in Moscow and in Saint-Petersburg in 2015 and 2018; determination of the localizations with main input in SMR from MN. Materials.Number of citizens and number of deaths from tumors accordingly to Rosstat Short nomenclature of the death reasons were evaluated. Death rates were calculated using the special computer programs on the base of European standard, comparison was provided with help of non-parametric criteria. Results.SMR of 29 from 33 MN localizations became lower in 2018 comparing to 2015 both in Moscow and in Saint-Petersburg. The average SMR decreased in 2018 in Saint-Petersburg statistically significant (p=0.003) and in Moscow non-significant (p=0.34). The largest SMR value both in 2015 and in 2018 in Moscow and in Saint-Petersburg as well were registered from 7 cancer localizations (trachea, bronchus, lungs; large intestine; breast; pancreas; rectum; prostate). The share of these SMR localizations in all MN was 57% and 54% in Moscow and 57 and 56% in Saint-Petersburg correspondingly. SMR of all 7 localizations were lower in Moscow comparing to Saint-Petersburg. SMR was lower in 2018 comparing to 2015 in both cities. The share of MN of others, unspecified, non-classified, etc. localizations in all MN was 11% in 2015 in both cities. Its share was in 2018 13.5% in Moscow and 10.1% in Saint Petersburg. Conclusions.SMR of most MN was higher in Saint Petersburg as in Moscow both in 2015 and in 2018. The analyses of the effectiveness of screening programs and of health care organization for patients with MN with highest SMR is needed. The questions of the differential diagnostics (intravital and postmortem) and of control the quality of medical death certificates filling in should be solved for the decrease of mortality of nonrefinement MN.

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“…В 2016 г. интегральный экономический ущерб бремени злокачественных новообразований составил 241,3 млрд руб., что эквивалентно 0,3 % ВВП РФ. При этом неучтенными остаются потери производительности членов семьи пациента, вынужденных кардинально изменить свою занятость [6]. Таким образом, вопросы профилактики ЗН имеют для РФ важное социально-экономическое значение.…”

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“…70 случаев среди мужчин изучаемого возраста и 9 среди женщин) и высокими потерями, которые, по данным Концевой с соавт. [6], на 2016 год в РФ составили 73501,2 млн руб. Общие потери и затраты для изучаемого муниципального образования рассчитали для мужчин и женщин по формуле…”

unclassified

“…где N/3 -среднегодовое количество случаев ЗН, ЭПЗ (РФ) -средние по Российской Федерации затраты на один случай (1202,675 тысячи руб. [6]). Рассчитаны уровни воздействия (paf) для отдельных факторов риска по формуле [23]:…”

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Assessment of the Contribution Made by Oncogenic Factors to the Risk of Malignant Neoplasms Development for the Urban Population of Working Age

Efimova¹,

Myl'nikova²

2021

Health Risk Analysis

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High morbidity and mortality caused by malignant neoplasms in various age groups among urban population remains a pressing issue that public healthcare has to solve in contemporary megacities. This research concentrated on assessing significance of oncogenic risk factors that could cause malignant neoplasms (MNs) occurrence among urban population aged 18–64 inclusively. 766 people living in an administrative and industrial center in Siberia took part in the research; MNs were diagnosed in 367 out of them (the test group). The research involved calculating individual carcinogenic risks. Oncogenic factors, both environmental and occupational ones, were examined for each patient; attention was also paid to peculiarities of medical and biological characteristics as well as tobacco smoking and alcohol intake. Impacts exerted by the examined factors on risks of MNs occurrence were determined via odds ratios with estimated confidence intervals. First detected MNs frequency amounted to 638.9 ± 41.9 cases per 100 thousand people among women aged 18–64, and 532.6 ± 41.9 cases among men (p > 0.05). The following factors were determined as ones causing elevated risks of MNs occur- rence: carcinogenic hazards at a workplace; hereditary predisposition; tobacco smoking; alcohol abuse; female sex; living under exposure to chemical carcinogens in the environment. Women tended to have certain diseases that are conventionally considered possible risk factors (viral hepatitis B and C and pancreatic diabetes) 1.3 and 2.4 times more frequently than men. All the obtained data can be used for developing a targeted program aimed at malignant neoplasms prevention among urban population and they can also become a vital component in a system for managing risks of malignant neoplasms occur- rence on a given territory.

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Economic damage of risk factors associated with morbidity and mortality from major chronic non-communicable diseases in Russia in 2016

Cited by 20 publications

References 16 publications

Association of Smoking with Indicators of the Structure and Function of Blood Vessels in Middle-aged Men

Association of Smoking with Indicators of the Structure and Function of Blood Vessels in Middle-aged Men

Malignant neoplasms mortality rates in Moscow and Saint Petersburg in 2015 and 2018

Assessment of the Contribution Made by Oncogenic Factors to the Risk of Malignant Neoplasms Development for the Urban Population of Working Age

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