Economic Consequences of Comorbid Depression, Anxiety, and Allergic Rhinitis

Changes in Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens

“…Change in the severity of allergic symptoms was positively correlated with changes in the severity of anxiety symptoms. This is consistent with previous research suggesting a connection between allergic inflammation and anxiety (22,25,43,44)]. On the other hand, we did not find, as we had hypothesized, a link between specific IgE antibody status and anxiety scores, possibly as a result of the low number of participants who were positive for tree pollen specific IgE antibody.…”

“…First, the psychological effects of being ill, as well as impairments of sleep secondary to nasal obstruction or inflammation may affect mood. Second, cytokines may lead to a mood disturbance via the expression of the enzyme indoleamine-2,3-dioxygenase, which shifts the synthesis of tryptophan from serotonin to kynurenin (13,43,46). The resultant acute tryptophan depletion results in decreased brain serotonin, which may contribute to both depression and anxiety.…”

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

“…It is associated with impairments in how patients function in day-to-day life (1053). It has been known for a long time that having an allergic reaction causes significant fatigue and mood changes (1054), some impairment of cognitive function (1055,1056), depression and anxiety (1057,1058). Impairments on QOL and work and school performance are common, particularly in patients with moderate/severe symptoms.…”

The impact of allergic rhinitis on work productivity

“…Nonetheless, the sIgE test has been acknowledged as an accurate tool, and may be useful to family physicians for identifying specific allergen sensitivities and for determining the need for further investigation and referral. 7,8 Because this test is highly specific and sensitive for IgE antibodies to most prevalent inhalant allergens, [9][10][11][12] testing provides family physicians with an accurate and easily interpretable baseline assessment of allergic disease. An accurate diagnosis is important to evaluate the extent to which lifestyle, health-related quality of life (HRQoL), and symptoms, are influenced by treatments or other options which could influence work productivity.…”