Economic burden of varicella in Europe in the absence of universal varicella vaccination

Pawaskar, Manjiri; Meroc, Estelle; Samant, Salome; Flem, Elmira; Benčina, Goran; Riera-Montes, Margarita; Heininger, Ulrich

doi:10.1186/s12889-021-12343-x

Cited by 16 publications

(17 citation statements)

References 104 publications

(95 reference statements)

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“…Since vaccine hesitancy is already recognized by the World Health Organization as one of the 10 biggest threads to global health [ 112 ], identification of factors that enhance individuals’ intention to accept vaccination is crucial to increase vaccine uptake. Several systematic reviews suggest that vaccination against a variety of diseases (i.e., pneumococcal disease, varicella, tuberculosis) is a cost-effective or cost-saving intervention [ 113 , 114 , 115 , 116 ]. Additionally, a recent systematic review showed that the COVID-19 vaccination program appears to be a cost-effective or cost-saving intervention [ 117 ].…”

Section: Discussionmentioning

confidence: 99%

Psychosocial Predictors of COVID-19 Vaccine Uptake among Pregnant Women: A Cross-Sectional Study in Greece

et al. 2023

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An understanding of the factors associated with the COVID-19 vaccine uptake in pregnant women is paramount to persuade women to get vaccinated against COVID-19. We estimated the vaccination rate of pregnant women against COVID-19 and evaluated psychosocial factors associated with vaccine uptake among them. We conducted a cross-sectional study with a convenience sample. In particular, we investigated socio-demographic data of pregnant women (e.g., age, marital status, and educational level), COVID-19 related variables (e.g., previous COVID-19 diagnosis and worry about the side effects of COVID-19 vaccines), and stress due to COVID-19 (e.g., danger and contamination fears, fears about economic consequences, xenophobia, compulsive checking and reassurance seeking, and traumatic stress symptoms about COVID-19) as possible predictors of COVID-19 vaccine uptake. Among pregnant women, 58.6% had received a COVID-19 vaccine. The most important reasons that pregnant women were not vaccinated were doubts about the safety and effectiveness of the COVID-19 vaccines (31.4%), fear that COVID-19 vaccines could be harmful to the fetus (29.4%), and fear of adverse side effects of COVID-19 vaccines (29.4%). Increased danger and contamination fears, increased fears about economic consequences, and higher levels of trust in COVID-19 vaccines were related with vaccine uptake. On the other hand, increased compulsive checking and reassurance seeking and increased worry about the adverse side effects of COVID-19 vaccines reduced the likelihood of pregnant women being vaccinated. An understanding of the psychosocial factors associated with increased COVID-19 vaccine uptake in pregnant women could be helpful for policy makers and healthcare professionals in their efforts to persuade women to get vaccinated against COVID-19. There is a need for targeted educational campaigns to increase knowledge about COVID-19 vaccines and reduce vaccine hesitancy in pregnancy.

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Section: Discussionmentioning

confidence: 99%

Psychosocial Predictors of COVID-19 Vaccine Uptake among Pregnant Women: A Cross-Sectional Study in Greece

et al. 2023

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“…The varicella cases with complications were not only associated with higher annual cost of antiviral and antibiotic prescriptions but also add to other direct (e.g., hospitalization, over-the-counter medications.) and indirect costs (e.g., productivity loss due to caregiver absenteeism) associated with varicella, which are not accounted for in this study [2,[24][25][26][27][28].…”

Section: Plos Onementioning

confidence: 99%

Impact of universal varicella vaccination on the use and cost of antibiotics and antivirals for varicella management in the United States

Pawaskar

Fergie

Harley³

et al. 2022

PLoS ONE

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Background Our objective was to estimate the impact of universal varicella vaccination (UVV) on the use and costs of antibiotics and antivirals for the management of varicella among children in the United States (US). Methods A decision tree model of varicella vaccination, infections and treatment decisions was developed. Results were extrapolated to the 2017 population of 73.5 million US children. Model parameters were populated from published sources. Treatment decisions were derived from a survey of health care professionals’ recommendations. The base case modelled current vaccination coverage rates in the US with additional scenarios analyses conducted for 0%, 20%, and 80% coverage and did not account for herd immunity benefits. Results Our model estimated that 551,434 varicella cases occurred annually among children ≤ 18 years in 2017. Antivirals or antibiotics were prescribed in 23.9% of cases, with unvaccinated children receiving the majority for base case. The annual cost for varicella antiviral and antibiotic treatment was approximately $14 million ($26 per case), with cases with no complications accounting for $12 million. Compared with the no vaccination scenario, the current vaccination rates resulted in savings of $181 million (94.7%) for antivirals and $78 million (95.0%) for antibiotics annually. Scenario analyses showed that higher vaccination coverage (from 0% to 80%) resulted in reduced annual expenditures for antivirals (from $191 million to $41 million), and antibiotics ($82 million to $17 million). Conclusions UVV was associated with significant reductions in the use of antibiotics and antivirals and their associated costs in the US. Higher vaccination coverage was associated with lower use and costs of antibiotics and antivirals for varicella management.

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“…10,11 That is, the Heart Failure Association of the European Society of Cardiology and the American Heart Association suggest COVID-19 vaccination as soon as possible to individuals with heart failure, heart disease, heart attack, and cardiovascular risk factors since they are high risk groups to develop COVID-19 outcomes. 12 Although vaccination promotes public health and it is a cost-effectiveness intervention even in case of COVID-19, [13][14][15] vaccine hesitancy is still one of the biggest threats to global health 16 . Socio-demographic variables, psychological factors, vaccine hesitancy, COVID-19 related variables, personal beliefs, knowledge, fear, conspiracy theories, fake news, and trust are the most important factors that influence individuals' decision to accept the COVID-19 vaccines.…”

Section: Introductionmentioning

confidence: 99%

COVID-19-related burnout reduces COVID-19 vaccination intention in cardiac patients: a cross-sectional study in Greece

Galanis

Katsiroumpa

Vraka

et al. 2023

Preprint

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Background: New SARS-CoV-2 variants have emerged and COVID-19 is still a public health issue, especially for vulnerable groups such as people with chronic medical conditions. Objective: To investigate the impact of COVID-19-related burnout on COVID-19 vaccination intention in cardiac patients. Moreover, we investigated other possible demographic and psychological predictors of vaccination intention in cardiac patients. Methods: We conducted a cross-sectional study in Greece using a convenience sample. Data collection was performed from 20 November 2022 to 10 January 2023. We measured demographic data, COVID-19-related burnout, anxiety, depression, social support, and resilience. We used the following valid tools: COVID-19 burnout scale, Patient Health Questionnaire-4, Multidimensional Scale of Perceived Social Support, and Brief Resilience Scale. Results: Among patients, 45.8% were willing to accept a COVID-19 booster dose, 25.3% were hesitant, and 28.9% were unwilling. Patients experienced moderate levels of COVID-19-related burnout. After multivariable linear regression analysis, we found that increased age and decreased emotional exhaustion due to COVID-19 were associated with increased vaccination intention. Moreover, patients who have already received a booster dose had also a greater willingness to accept a new booster dose. Conclusions: Identification of factors that influence patients decision to accept a COVID-19 booster dose is crucial to maintain a high vaccination coverage rate among them in order to avoid COVID-19-related outcomes. Since a COVID-19 booster dose on an annual basis seems to be necessary policy makers should develop and implement vaccination programmes tailored for patients.

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Economic burden of varicella in Europe in the absence of universal varicella vaccination

Cited by 16 publications

References 104 publications

Psychosocial Predictors of COVID-19 Vaccine Uptake among Pregnant Women: A Cross-Sectional Study in Greece

Psychosocial Predictors of COVID-19 Vaccine Uptake among Pregnant Women: A Cross-Sectional Study in Greece

Impact of universal varicella vaccination on the use and cost of antibiotics and antivirals for varicella management in the United States

COVID-19-related burnout reduces COVID-19 vaccination intention in cardiac patients: a cross-sectional study in Greece

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