Abstract:Introduction: In 2017, 1.5 million people were diagnosed with stroke, 9 million were living with stroke and 0.4 million died because of stroke in 32 European countries. We estimate the economic burden of stroke across these countries in 2017. Patients and methods: In a population-based cost analysis, we evaluated the cost of stroke. We estimated overall health and social care costs from expenditure on care in the primary, outpatient, emergency, inpatient and nursing/ residential care settings, and pharmaceutic… Show more
“…The healthcare burden of stroke in European Union (EU) was approximately €20 billion in 2015, and €27 billion in 2017. In 2015, almost 72% of these expenses were represented by hospital care [7], and in 2017 a decrease of the percentage was observed; only 45% of the expanses were incurred by healthcare systems [8]. The results of the studies revealed that the costs regarding stroke (health and social care costs) / capita are associated with increases in a nation's wealth, resulting in increased stroke-related costs [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…In 2015, almost 72% of these expenses were represented by hospital care [7], and in 2017 a decrease of the percentage was observed; only 45% of the expanses were incurred by healthcare systems [8]. The results of the studies revealed that the costs regarding stroke (health and social care costs) / capita are associated with increases in a nation's wealth, resulting in increased stroke-related costs [7,8]. Also, large variations in health and social care expenses for stroke have been indicated, even for those countries with similar levels of national income [8].…”
Section: Introductionmentioning
confidence: 99%
“…The results of the studies revealed that the costs regarding stroke (health and social care costs) / capita are associated with increases in a nation's wealth, resulting in increased stroke-related costs [7,8]. Also, large variations in health and social care expenses for stroke have been indicated, even for those countries with similar levels of national income [8]. In 2015, in Romania, the costs / patient in case of stroke were about €8, occupying the penultimate place in the EU, ahead of Bulgaria (€7) and far from Finland, with the highest costs (€132) [7].…”
Section: Introductionmentioning
confidence: 99%
“…In 2015, in Romania, the costs / patient in case of stroke were about €8, occupying the penultimate place in the EU, ahead of Bulgaria (€7) and far from Finland, with the highest costs (€132) [7]. The overall expenditures are however, doubled, and this huge burden of stroke on the economy is supported by the society through contributions to insurance and payment of taxes but also, considerably, by the survivors of stroke and their caregivers [7,8].…”
Stroke represents a serious illness and is extremely relevant from the public health point of view, implying important social and economic burdens. Introducing new procedures or therapies that reduce the costs both in the acute phase of the disease and in the long term becomes a priority for health systems worldwide. The present study quantifies and compares the direct costs for ischemic stroke in patients with thrombolysis treatment versus conservative treatment over a 24-month period from the initial diagnosis, in one of the 7 national pilot centres for the implementation of thrombolytic treatment. The significant reduction (p < 0.001) of the hospitalization period, especially of the days in the intensive care unit (ICU) for stroke, resulted in a significant reduction (p < 0.001) of the total average costs in the patients with thrombolysis, both at the first hospitalization and for the subsequent hospitalizations, during the period followed in the study. It was also found that the percentage of patients who were re-hospitalized within the first 24-months after stroke was significantly lower (p < 0.001) among thrombolyzed patients. The present study demonstrates that the quick intervention in cases of stroke is an efficient policy regarding costs, of Romanian Public Health System, Romania being the country with the highest rates of new strokes and deaths due to stroke in Europe.
“…The healthcare burden of stroke in European Union (EU) was approximately €20 billion in 2015, and €27 billion in 2017. In 2015, almost 72% of these expenses were represented by hospital care [7], and in 2017 a decrease of the percentage was observed; only 45% of the expanses were incurred by healthcare systems [8]. The results of the studies revealed that the costs regarding stroke (health and social care costs) / capita are associated with increases in a nation's wealth, resulting in increased stroke-related costs [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…In 2015, almost 72% of these expenses were represented by hospital care [7], and in 2017 a decrease of the percentage was observed; only 45% of the expanses were incurred by healthcare systems [8]. The results of the studies revealed that the costs regarding stroke (health and social care costs) / capita are associated with increases in a nation's wealth, resulting in increased stroke-related costs [7,8]. Also, large variations in health and social care expenses for stroke have been indicated, even for those countries with similar levels of national income [8].…”
Section: Introductionmentioning
confidence: 99%
“…The results of the studies revealed that the costs regarding stroke (health and social care costs) / capita are associated with increases in a nation's wealth, resulting in increased stroke-related costs [7,8]. Also, large variations in health and social care expenses for stroke have been indicated, even for those countries with similar levels of national income [8]. In 2015, in Romania, the costs / patient in case of stroke were about €8, occupying the penultimate place in the EU, ahead of Bulgaria (€7) and far from Finland, with the highest costs (€132) [7].…”
Section: Introductionmentioning
confidence: 99%
“…In 2015, in Romania, the costs / patient in case of stroke were about €8, occupying the penultimate place in the EU, ahead of Bulgaria (€7) and far from Finland, with the highest costs (€132) [7]. The overall expenditures are however, doubled, and this huge burden of stroke on the economy is supported by the society through contributions to insurance and payment of taxes but also, considerably, by the survivors of stroke and their caregivers [7,8].…”
Stroke represents a serious illness and is extremely relevant from the public health point of view, implying important social and economic burdens. Introducing new procedures or therapies that reduce the costs both in the acute phase of the disease and in the long term becomes a priority for health systems worldwide. The present study quantifies and compares the direct costs for ischemic stroke in patients with thrombolysis treatment versus conservative treatment over a 24-month period from the initial diagnosis, in one of the 7 national pilot centres for the implementation of thrombolytic treatment. The significant reduction (p < 0.001) of the hospitalization period, especially of the days in the intensive care unit (ICU) for stroke, resulted in a significant reduction (p < 0.001) of the total average costs in the patients with thrombolysis, both at the first hospitalization and for the subsequent hospitalizations, during the period followed in the study. It was also found that the percentage of patients who were re-hospitalized within the first 24-months after stroke was significantly lower (p < 0.001) among thrombolyzed patients. The present study demonstrates that the quick intervention in cases of stroke is an efficient policy regarding costs, of Romanian Public Health System, Romania being the country with the highest rates of new strokes and deaths due to stroke in Europe.
“…Stroke is the most frequent cause of permanent disability in adults and one of the most important causes of death [1]. Over the next years, global stroke burden is expected to increase steadily, mainly because of population aging [2]. Ischemic stroke remains to represent more than 80% of all strokes.…”
Background- Inflammatory response plays an important role in many processes related to acute ischemic stroke (AIS). Calprotectin (S100A8/S100A9), released by monocytes and neutrophils, is a key protein in the regulation of inflammation and thrombosis. The purpose of this study is to evaluate the association of circulating calprotectin with other inflammatory biomarkers and AIS prognosis, as well as the calprotectin content in stroke thrombi.Methods- Among the 748 patients treated at a comprehensive stroke centre between 2015-2017, 413 patients with confirmed acute ischemic injury were evaluated. Patients with systemic inflammation or infection at onset were excluded. Plasma calprotectin was measured by ELISA in blood samples of AIS patients within the first 24h. Univariate and multivariate logistic regression models were performed to evaluate its association with mortality and functional independence (FI) at 3-months (defined as modified Rankin Scale<2), and intracranial haemorrhage (ICH) after stroke. Further, S100A9 was localized by immunostaining in stroke thrombi (n=44). Results- Higher calprotectin levels were associated with 3-month mortality and ICH, while lower calprotectin levels were documented in patients with 3-month FI. After adjusting for potential confounders, plasma calprotectin levels remained associated with 3-month mortality [OR (95%CI); 3.06, (1.67-5.61)]. Patients with calprotectin≥2.26 µg/mL were 4-times more likely to die [OR 3.98, (1.88-8.41)]. Likewise, Neutrophil-Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) were also associated with 3-month mortality [OR 1.98, (1.17-3.35); and 1.39, (1.02-1.89) respectively]. A multimarker approach demonstrated that patients with increased calprotectin, CRP and NLR had the poorest outcome with a mortality rate of 42.3% during follow-up. S100A9 protein, as part of the heterodimer calprotectin, was present in all thrombi retrieved from AIS patients. Mean S100A9 content was 3.5% and tended to be higher in patients who died (p=0.09). Moreover, it positively correlated with platelets (Pearson r 0.46, p<0.002); leukocytes (0.45, p<0.01) and neutrophil elastase (0.70, p<0.001) thrombi content. Conclusions- Plasma calprotectin is an independent predictor of 3-month mortality and provides complementary prognostic information to identify patients with poor outcome after AIS. Presence of S100A9 in stroke thrombi suggests a possible inflammatory mechanism in clot formation and further studies are needed to determine its influence in resistance to reperfusion.
Payers and manufacturers can disagree on the appropriate level of evidence that is required for new medical devices, resulting in high societal costs due to decisions taken with sub‐optimal information. A cost‐effectiveness model of a hypothetical total artificial heart was built using data from the literature and the (simulated) results of a pivotal study. The expected value of perfect information (EVPI) was calculated from both the payer and manufacturer perspectives, using net monetary benefit and the company's return on investment respectively. A function was also defined, linking effectiveness to market shares. Additional constraints such as a minimum clinical difference or maximum budget impact were introduced into the company's decisions to simulate additional barriers to adoption. The difference in the EVPI between manufacturers and payers varied greatly depending on the underlying decision rules and constraints. The manufacturer's EVPI depends on the probability of being reimbursed, the uncertainty on the (cost‐)effectiveness of the technology, as well as other parameters relating to initial investments, operating costs and market dynamics. The use of Value of information for both perspectives can outline potential misalignments and can be particularly useful to inform early dialogs between manufacturers and payers, or negotiations on conditional reimbursement schemes.
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