Economic Burden of Stroke: A Systematic Review on Post-Stroke Care

Rajsic, S; Gothe, Holger; Borba, HH; Vujičić, Jelena; Toell, Thomas; Siebert, U.

doi:10.1016/j.jval.2016.09.1649

Cited by 36 publications

(38 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Stroke was the second most frequent cause of death and the third most frequent cause of disability worldwide. In a recent systematic review, poststroke care costs per patient month were estimated to range from $752 in Australia to $4850 in the USA, underlining the substantial overall economic burden associated with this neurological condition [2]. Altogether, these findings clearly demonstrate the importance of better stroke prevention in the future.…”

Section: Introductionmentioning

confidence: 99%

Long‐term risk of stroke and its predictors in transient ischaemic attack patients in Germany

Jacob

Tanislav

Kostev³

2019

Euro J of Neurology

View full text Add to dashboard Cite

Background and purpose Little is known about the long‐term association between transient ischaemic attack (TIA) and stroke. Therefore, the goal of this study was to analyze the long‐term risk of stroke and associated predictors in a large cohort of TIA patients followed in general practices in Germany. Methods This study included patients with an initial TIA diagnosis and subsequently followed up in one of 1262 general practices in Germany between January 2007 and December 2016 (N = 19 824 patients). The primary outcome of the study was the risk of ischaemic stroke within 10 years of the initial diagnosis of TIA. The secondary outcome was the identification of demographic, clinical and pharmaceutical variables significantly associated with stroke in TIA patients. Results Within 10 years of the initial TIA diagnosis, 18.3% of individuals were diagnosed with stroke. Age was positively associated with stroke, with hazard ratios ranging from 1.88 in patients aged 51–60 years to 4.00 in those aged >80 years (reference group: patients aged ≤50 years). Furthermore, male sex, hypertension, diabetes mellitus, atrial fibrillation and ischaemic heart diseases had an additional impact on the risk of stroke. Finally, new oral anticoagulants, heparins, diuretics, angiotensin II receptor blockers and platelet aggregation inhibitors were identified as protective factors. Conclusions In a cohort of almost 20 000 TIA patients, 18.3% were diagnosed with stroke within 10 years after the TIA index event. Several demographic, clinical and pharmaceutical variables significantly predicted the long‐term risk of stroke in TIA patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Long‐term risk of stroke and its predictors in transient ischaemic attack patients in Germany

Jacob

Tanislav

Kostev³

2019

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…Globally, stroke is a leading cause of mortality and disability, and the substantial economic costs for poststroke care and treatment are needed [ 1 ]. A study from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) showed that stroke is the second largest cause of death worldwide (5.5 million (95% UI 5.3–5.7)) in 2016, and the overall burden of stroke remains high [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Tetramethylpyrazine on Neuroplasticity after Transient Focal Cerebral Ischemia Reperfusion in Rats

Lin

Hao

Gong

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Tetramethylpyrazine (TMP) has been widely used in ischemic stroke in China. The regulation of neuroplasticity may underlie the recovery of some neurological functions in ischemic stroke. Middle cerebral artery occlusion (MCAO) model was established in this study. Rats were divided into three groups: sham group, model group, and TMP group. The neurological function was evaluated using modified neurological severity score (mNSS). Following the neurological function test, expression of synaptophysin (SYP) and growth-associated protein 43 (GAP-43) were analyzed through immunohistochemistry at 3 d, 7 d, 14 d, and 28 d after MCAO. Finally, the synaptic structural plasticity was investigated using transmission electron microscopy (TEM). The TMP group showed better neurological function comparing to the model group. SYP levels increased gradually in ischemic penumbra (IP) in the model group and could be enhanced by TMP treatment at 7 d, 14 d, and 28 d, whereas GAP-43 levels increased from 3 d to 7 d and thereafter decreased gradually from 14 d to 28 d in the model group, which showed no significant improvement in the TMP group. The results of TEM showed a flatter synaptic interface, a thinner postsynaptic density (PSD), and a wider synaptic cleft in the model group, and the first two alterations could be ameliorated by TMP. Then, a Pearson’s correlation test revealed mNSS markedly correlated with SYP and synaptic ultrastructures. Taken together, TMP is capable of promoting functional outcome after ischemic stroke, and the mechanisms may be partially associated with regulation of neuroplasticity.

show abstract

“…Stroke itself can result in minor to major, short and longterm physical disabilities [1], cognitive impairments [2,3], emotional disturbances [4,5], decreased social interactions [6] and excessive economic burden [7]. In addition to neurological problems appearing in the immediate post-stroke period [8], often there are multiple late complications [9] which should not to be neglected.…”

Section: Introductionmentioning

confidence: 99%

Determinants of complications in ﬁrst ever acute stroke patients: a prospective observational study from India

2021

Signa Vitae

View full text Add to dashboard Cite

Background and Aims: Post-stroke complications can lead to frequent and major causes of death in the early phases after an acute stroke. Aims of the present study were to determine the association of several risk factors with the occurrence of poststroke complications, the predictors for the development of complications, and to evaluate how these complications affected the overall prognosis among subjects with the first ever acute stroke. This study is the pioneer study of this kind from Eastern India. Previous national and international studies on this lack uniformity in their results probably because of the following reasons: no standard definitions for complications following the stroke, varied follow-up periods ranging from 1 week to 30 months, type and severity of stroke affecting the incidence, and finally, the demographic variables. Methods: This was an observational, prospective study, in which a total of 521 adult male and female patients who had a first-ever acute stroke, aged between 12 years to 75 years were enrolled over a period of 2 years (September 2016 to September 2018), admitted in Department of Neuromedicine, Bangur Institute of Neurosciences (BIN), Kolkata, India. Patients with first ever acute stroke were studied for post-stroke complications (predefined with standard criteria) during the hospital stay at Bangur Institute of Neurosciences (BIN), Kolkata, India, and their association with risk factors, severity of stroke (National Institutes of Health Stroke Scale Score, NIHSS), length of hospital stay (in days) and outcome (Modified Rankin Scale, MRS) were assessed. Results: A total of screened 498 patients who were admitted at Bangur Institute of Neurosciences (BIN), Kolkata, India, with first ever acute stroke were recruited. The mean age was 61.02 years (range 23-75 years), the majority being male (n = 307; 61.6%). Post-stroke complication during hospital stay was documented in 270 patients (54.2%)(males and females combined). In logistic regression analysis, multiple risk factors (OR, 1.571; 95% CI, 1.084-2.278; P-0.017), severity of stroke (National Institutes of Health Stroke Scale Score, NIHSS) (OR, 1.425; 95% CI, 1.027-1.976; P-0.034) and length of hospital stay (in days) (OR, 3.565; 95% CI, 2.029-6.264; P < 0.0001) were the most robust predictors of occurrence of complications. The independent predictors of poor outcome in subjects with complications were: chest infection (OR, 2.07; 95% CI, 1.006-4.26; P = 0.048), bedsores (OR, 2.26; 95% CI, 1.03-4.94; P-0.042), and seizures (OR, 5.072; 95% CI, 1.08-23.79; P-0.039). Conclusion: In our study, the most independent predictors of complications were severity of stroke and length of hospital stay. This observation might help clinicians in taking appropriate measures towards preventing post-stroke complications and thereby improving outcome following a stroke.

show abstract

Economic Burden of Stroke: A Systematic Review on Post-Stroke Care

Cited by 36 publications

References 0 publications

Long‐term risk of stroke and its predictors in transient ischaemic attack patients in Germany

Long‐term risk of stroke and its predictors in transient ischaemic attack patients in Germany

Effect of Tetramethylpyrazine on Neuroplasticity after Transient Focal Cerebral Ischemia Reperfusion in Rats

Determinants of complications in ﬁrst ever acute stroke patients: a prospective observational study from India

Contact Info

Product

Resources

About