“…A frequently overlooked issue in measuring the advances in breast cancer management has been the impact of these advances on healthcare resource utilization. In the current issue of Advances in Modern Oncology Research, a population-based study evaluating the economic burden of patients with inoperable advanced breast cancer receiving early or late capecitabine or trastuzumab as second-line treatment, is being presented [4] . The authors found that early or late capecitabine or trastuzumab administration after first-line anthracycline or taxane-based treatments did not exhibit a change in healthcare resource utilization.…”