Economic Burden of Irritable Bowel Syndrome with Constipation: A Retrospective Analysis of Health Care Costs in a Commercially Insured Population

Doshi, Jalpa A.; Cai, Qing; Buono, Jessica; Spalding, William; Sarocco, Phil; Tan, Hiangkiat; Stephenson, Judith J.; Carson, Robyn

doi:10.18553/jmcp.2014.20.4.382

Cited by 56 publications

(66 citation statements)

References 18 publications

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“…In United States, IBS-D was more common in males (37.5%), and IBS-C more common in females (47%)[8]. In Japan IBS-M was of similar prevalence in the females and males at 45% and 49% respectively[51]. In South Korea, the most commonly encountered IBS subtype with similar prevalence of 38.3% and 33.8% in females and males respectively was IBS-D[28].…”

Section: Discussionmentioning

confidence: 99%

Economic burden of irritable bowel syndrome in China

Zhang

Xiang

et al. 2016

WJG

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AIMTo estimate annual direct and indirect costs for patients diagnosed with irritable bowel syndrome (IBS) and subtypes.METHODSPatients completed a standardized questionnaire concerning usage of healthcare resources, travel costs, meals, and productivity loss of patients when seeking treatment for IBS. Total annual costs per patient were calculated as the sum of direct (including medical and nonmedical) and indirect costs. Total annual costs per patient among various IBS subtypes were compared. Analysis of variance and bootstrapped independent sample t-tests were performed to determine differences between groups after controlling for IBS subtypes.RESULTSA total of 105 IBS patients (64.80% female), mean age of 57.12 years ± 10.31 years), mean disease duration of 4.31 years ± 5.40 years, were included. Total annual costs per patient were estimated as CNY18262.84 (USD2933.08). Inpatient and outpatient healthcare use were major cost drivers, accounting for 46.41%and 23.36% of total annual costs, respectively. Productivity loss accounted for 25.32% of total annual costs. The proportions of direct and indirect costs were similar to published studies in other countries. Nationally, the total costs of managing IBS would amount to CNY123.83 billion (USD1.99 billion). Among the IBS subtypes, total annual costs per patient of IBS-M was highest at CNY18891.18 (USD3034). Furthermore, there was significant difference in productivity loss among IBS subtypes (P = 0.031).CONCLUSIONIBS imposes a huge economic burden on patients and healthcare systems, which could account for 3.3% of the total healthcare budget for the entire Chinese nation. More than two-thirds of total annual costs of IBS consist of inpatient and outpatient healthcare use. Among the subtypes, IBS-M patients appear to have the greatest economic burden but require further confirmation.

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Section: Discussionmentioning

confidence: 99%

Economic burden of irritable bowel syndrome in China

Zhang

Xiang

et al. 2016

WJG

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“…More recently, a US study (2010 data) calculated inpatient and outpatient annual costs associated with IBS-C to be equivalent to £96.01 and £612.04, respectively, with overall costs of £857.20 per patient per year for IBS-C-related medical and prescription costs 20. When all medical and prescription costs for patients with IBS-C were included, this rose to annual costs equivalent to £1565.23, £3855.64 and £7179.96 in 2010, respectively.…”

Section: Discussionmentioning

confidence: 99%

Burden of irritable bowel syndrome in an increasingly cost-aware National Health Service

Soubières

Wilson

Poullis

et al. 2015

Frontline Gastroenterol

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“…IBS is a painful condition associated with significant psychological distress and psychiatric comorbidities, like higher levels of anxiety or depression and suicidal ideation, with negative impact on quality of life [2, 3]. Its consequences are measured in direct cost (medical treatment and procedures) and indirect cost (reduced productivity) [4]. …”

Section: Introductionmentioning

confidence: 99%

The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations

et al. 2014

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Irritable bowel syndrome (IBS) is a functional syndrome characterized by chronic abdominal pain accompanied by altered bowel habits. Although generally considered a functional disorder, there is now substantial evidence that IBS is associated with a poor quality of life and significant negative impact on work and social domains. Neuroimaging studies documented changes in the prefrontal cortex, ventro-lateral and posterior parietal cortex and thalami, and implicate alteration of brain circuits involved in attention, emotion and pain modulation. Emerging data reveals the interaction between psychiatric disorders including generalized anxiety disorder, panic disorder, major depressive disorder, bipolar disorder, and schizophrenia and IBS, which suggests that this association should not be ignored when developing strategies for screening and treatment. Psychological, social and genetic factors appear to be important in the development of IBS symptomatology through several mechanisms: alteration of HPA axis modulation, enhanced perception of visceral stimuli or psychological vulnerability. Elucidating the molecular mechanisms of IBS with or without psychiatric comorbidities is crucial for elucidating the pathophysiology and for the identification of new therapeutical targets in IBS.

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Economic Burden of Irritable Bowel Syndrome with Constipation: A Retrospective Analysis of Health Care Costs in a Commercially Insured Population

Abstract: BACKGROUND: The prevalence of irritable bowel syndrome with constipation (IBS-C) is estimated to be between 4.3% and 5.2% among adults in the United States. Little is known about the health care resource utilization and costs associated with IBS-C.

Cited by 56 publications

References 18 publications

Economic burden of irritable bowel syndrome in China

Economic burden of irritable bowel syndrome in China

Burden of irritable bowel syndrome in an increasingly cost-aware National Health Service

The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations

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