Economic burden of head and neck cancer

Lee, Jennifer M; Turini, Marco; Botteman, Marc; Stephens, Jennifer; Pashos, Chris L.

doi:10.1007/s10198-003-0204-3

Cited by 45 publications

(36 citation statements)

References 51 publications

(55 reference statements)

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“…Prospective studies would be a good alternative, and not many have been published in HNC. This has not changed since the review of the economics of HNC published in 2004 by Lee et al [95], who noted a plethora of cost identification studies but very few with a prospective design. Adding economic endpoints to trials enrolling head and neck patients would be a good tack to take in any region.…”

Section: Discussionmentioning

confidence: 99%

The Economic Burden of Head and Neck Cancer: A Systematic Literature Review

et al. 2014

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BackgroundThis systematic literature review aimed to evaluate and summarize the existing evidence on resource use and costs associated with the diagnosis and treatment of head and neck cancer (HNC) in adult patients, to better understand the currently available data. The costs associated with HNC are complex, as the disease involves multiple sites, and treatment may require a multidisciplinary medical team and different treatment modalities.MethodsDatabases (MEDLINE and Embase) were searched to identify studies published in English between October 2003 and October 2013 analyzing the economics of HNC in adult patients. Additional relevant publications were identified through manual searches of abstracts from recent conference proceedings.ResultsOf 606 studies initially identified, 77 met the inclusion criteria and were evaluated in the assessment. Most included studies were conducted in the USA. The vast majority of studies assessed direct costs of HNC, such as those associated with diagnosis and screening, radiotherapy, chemotherapy, surgery, side effects of treatment, and follow-up care. The costs of treatment far exceeded those for other aspects of care. There was considerable heterogeneity in the reporting of economic outcomes in the included studies; truly comparable cost data were sparse in the literature. Based on these limited data, in the US costs associated with systemic therapy were greater than costs for surgery or radiotherapy. However, this trend was not seen in Europe, where surgery incurred a higher cost than radiotherapy with or without chemotherapy.ConclusionsMost studies investigating the direct healthcare costs of HNC have utilized US databases of claims to public and private payers. Data from these studies suggested that costs generally are higher for HNC patients with recurrent and/or metastatic disease, for patients undergoing surgery, and for those patients insured by private payers. Further work is needed, particularly in Europe and other regions outside the USA; prospective studies assessing the cost associated with HNC would allow for more systematic comparison of costs, and would provide valuable economic information to payers, providers, and patients

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Section: Discussionmentioning

confidence: 99%

The Economic Burden of Head and Neck Cancer: A Systematic Literature Review

et al. 2014

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“…Among all cancers in Taiwanese males, oral cancer which contributed 70% of head and neck cancer has been ranked fourth in incidence and mortality since 1995. It is an obvious consequence that the treatment of oral cancer makes an increasing economic burden [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Disparities in Oral Cancer Survival among Mentally Ill Patients

Chang

Hou

et al. 2013

PLoS ONE

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BackgroundMany studies have reported excess cancer mortality in patients with mental illness. However, scant studies evaluated the differences in cancer treatment and its impact on survival rates among mentally ill patients. Oral cancer is one of the ten most common cancers in the world. We investigated differences in treatment type and survival rates between oral cancer patients with mental illness and without mental illness.MethodsUsing the National Health Insurance (NHI) database, we compared the type of treatment and survival rates in 16687 oral cancer patients from 2002 to 2006. The utilization rate of surgery for oral cancer was compared between patients with mental illness and without mental illness using logistic regression. The Cox proportional hazards model was used for survival analysis.ResultsOral cancer patients with mental disorder conferred a grave prognosis, compared with patients without mental illness (hazard ratios [HR] = 1.58; 95% confidence interval [CI] = 1.30–1.93; P<0.001). After adjusting for patients’ characteristics and hospital characteristics, patients with mental illness were less likely to receive surgery with or without adjuvant therapy (odds ratio [OR] = 0.47; 95% CI = 0.34–0.65; P<0.001). In multivariate analysis, oral cancer patients with mental illness carried a 1.58-times risk of death (95% CI = 1.30–1.93; P<0.001).ConclusionsOral cancer patients with mental illness were less likely to undergo surgery with or without adjuvant therapy than those without mental illness. Patients with mental illness have a poor prognosis compared to those without mental illness. To reduce disparities in physical health, public health strategies and welfare policies must continue to focus on this vulnerable group.

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“…The cost of illness has been estimated for some specific countries, like the UK [16], the USA [17], the Netherlands [18], Greece or Germany [19], using various methodologies. Moreover, as these cancers presented great variation in terms of localisation and incidence rate worldwide, the use of economic estimations performed in others countries may be hazardous.…”

Section: Introductionmentioning

confidence: 99%

Head and neck cancers in France: an analysis of the hospital medical information system (PMSI) database

Guily

Borget

Vainchtock³

et al. 2010

Head Neck Oncol

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BackgroundWith 16,005 new cases and 5,406 related deaths in 2005, France is particularly concerned by Head and Neck (H&N) cancers. In addition to tobacco and alcohol, Human Papillomavirus (HPV) has been reported as a risk factor for H&N cancers. The literature on the burden of these cancers in Europe is scarce. This study was performed to assess the medical and economical burden of hospitalisations for H&N cancers in France.MethodsThe French national hospital database (PMSI), in which admissions to public and private hospitals are recorded, was retrospectively analysed to assess the annual number of patients hospitalised for H&N cancers and associated hospital costs from the healthcare payer perspective. ICD-10 codes (16 codes classified as oral cavity, oropharynx, pharynx, salivary glands and larynx) were used to extract admissions for these cancers. Hospital stays, chemotherapy and radiotherapy sessions were extracted to assess patients' management. Costs of admissions were obtained from French official tariffs.ResultsIn 2007, there were 36 268 patients hospitalised for H&N cancers, of whom 81% were men, corresponding to 60 200 hospital stays and 287 846 sessions of chemo- or radio-therapy. Oropharynx cancer was the most frequent (28% of patients), followed by oral cavity cancer (25% of patients). The peak of frequency was observed in the 55-59 years age group. Patients were mainly treated in medicine (48%) and surgery (23%) units. Mean annual cost per patient ranged from €2 764 to €7 673 leading to a total hospital cost of €323 millions in 2007 (including hospitalization and expensive drugs). With 26% of H&N cancers attributable to HPV infections, 9 430 patients were hospitalized due to HPV-related H&N cancers, representing €138 million in 2007.ConclusionEven without taking into account the rehabilitation costs, the hospital burden of H&N cancers is considerable.

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Economic burden of head and neck cancer

Cited by 45 publications

References 51 publications

The Economic Burden of Head and Neck Cancer: A Systematic Literature Review

The Economic Burden of Head and Neck Cancer: A Systematic Literature Review

Disparities in Oral Cancer Survival among Mentally Ill Patients

Head and neck cancers in France: an analysis of the hospital medical information system (PMSI) database

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