Economic burden of deep infiltrating endometriosis of the bowel and the bladder in Germany: The statutory health insurance perspective

Koltermann, Katharina C.; Schlotmann, Andreas; Willich, Stefan N.; Reinhold, Thomas

doi:10.1016/j.zefq.2016.09.006

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…3,4 Endometriosis is a disease that entails a significant burden on women's quality of life and on healthcare systems, mainly due to the incapacitating symptoms of pain, the presence of infertility and the delay and high cost of diagnosis and treatment. 1,5,6 In addition, all health care costs involved with endometriosis were comparable to the other chronic conditions. 1 The etiology of endometriosis remains unknown, although the most accepted theory is regarding retrograde menstruation, described by Sampson, in 1927.…”

Section: Introductionmentioning

confidence: 86%

Epidemiological profile of women with endometriosis: a retrospective descriptive study

Cardoso

Machado

Silva

et al. 2020

Rev. Bras. Saude Mater. Infant.

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Objectives: to describe the epidemiological and clinical profile of women with endometriosis and to determine the association with the prognostic characteristics of the disease. Methods: retrospective descriptive study involving 237 women attended at two referral hospitals for endometriosis, between 2011 and 2017. Associations between groups were estimated using logistic regression models. Results: most women (65.4%) were of reproductive age (29-39 years), with a body mass index in the range of 18.5-24.9 kg/m2 and a high prevalence (23-81%) of symptoms of the disease, with 49.5% being infertile. The average time of diagnosis was 5 years. Ovarian endometrioma and/or deep infiltrative endometriosis (DIE) were the most frequent type of endometriosis (87%), and 59% of patients were in the III/IV stage of the disease. Approximately 87% of women with surgical diagnosis were aged over 30, married (70%) and had lower parity. Dyspareunia was negatively associated with superficial endometriosis. Infertility was positively associated with age (30-39 years) and DIE in the uterine tubes; dysmenorrhea with DIE in the uterosacral ligament; cyclic intestinal complaints with DIE in the rectosigmoid and intestine, and with DIE classification and III/IVstage. Conclusions: knowing the epidemiological and clinical profile of Brazilian women with endometriosis can help in diagnosis and treatment planning.

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Section: Introductionmentioning

confidence: 86%

Epidemiological profile of women with endometriosis: a retrospective descriptive study

Cardoso

Machado

Silva

et al. 2020

Rev. Bras. Saude Mater. Infant.

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“…It affects approximately 10% of women at reproductive age [2] and directly disturbs their quality of life. This can be because of the delay and elevated cost of the treatment and diagnosis, beyond the incapacitating symptoms [3,4], of which infertility stands out. A recent study conducted in a Swedish cohort with 3406 women, followed by thirty-nine years, showed an increased rate of endometriosis among women with previous infertility problems [5].…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinases 3 polymorphism increases the risk of developing advanced endometriosis and infertility: A case-control study

Cardoso

Machado

Silva

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective Endometriosis has a complex and multifactorial pathology, and it is considered one of the main causes of infertility nowadays. The angiogenic process, which involves remodeling of extracellular matrix, is crucial for the development of this disease, mainly by the action of the matrix metalloproteinase 3 (MMP-3). It is known that genetic factors can influence endometriosis, thus; we investigated the role of MMP3 276G>A polymorphism as a risk factor for the development of the disease and its symptoms. Study Design This case-control study included 283 women with endometriosis (cases) and 217 women without the disease (controls) who were submitted to laparoscopic or laparotomy surgery. Real-time polymerase chain reaction performed by TaqMan system was applied for all polymorphisms. A multivariate logistic regression was performed to evaluate the association between polymorphism and endometriosis or clinical and gynecological characteristics of the disease, using their respective odds ratios (OR) and 95% confidence intervals (CI). Results The allelic frequency of the MMP3 276 G > A polymorphism was 33.6% in controls and 40.3% in endometriosis cases. The allelic distribution was significantly different between the two ( P = 0.03). The variant genotype of MMP3 276AA was associated with increased endometriosis risk in the advanced endometriosis cases (OR: 2.08, 95% CI: 1.05 – 4.07 and OR: 1.87, 95% CI: 1.01 – 3.45). Regarding the symptoms, endometriosis-related infertile women had a positive association with the presence of MMP3 276 G > A polymorphism (OR: 3.13, 95% CI: 1.08–9.08 and OR: 3.30, 95% CI: 1.31 – 8.33). Conclusions These findings suggest that the MMP3 276A polymorphism is involved with advanced endometriosis cases and infertility, and these associations may implicate in the behavior of disease.

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“…É notório o impacto negativo da doença tanto no sistema de saúde como de forma ainda mais intensa na mulher portadora, prejudicando inclusive sua qualidade de vida, principalmente porque pode causar dores incapacitantes, a presença de infertilidade, bem como a demora e alto custo de exames diagnósticos e para o seu tratamento, que até o momento ainda é inespecífico e apresenta incertezas quanto a recorrência da doença (Denny & H Mann, 2007;Krina et al, 2020;Koltermann et al, 2016;Hughes et al, 2015).…”

Section: Endometriose No Brasilunclassified

Endometriose, dificuldades no diagnóstico precoce e a infertilidade feminina: Uma Revisão

Torres

Araújo

Vieira

et al. 2021

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A endometriose é uma patologia que afeta milhares de mulheres no mundo, isso se deve à presença de tecido endometrial extrauterino, que responde à estimulação hormonal e pode causar uma reação inflamatória resultando em sintomas como dor pélvica crônica severa e infertilidade. No Brasil, cerca de 7 milhões de mulheres sofrem com a doença, cujo diagnóstico, prontuário e pesquisas são altamente deficientes, o que dificulta a recuperação das pacientes. Desse modo, este estudo teve como objetivo investigar as dificuldades no diagnóstico precoce da endometriose e sua relação com a infertilidade feminina por meio de uma revisão narrativa. Foram realizadas buscas bibliográficas nas seguintes bases de dados: SciELO, PubMed/MEDLINE e BVS, por se tratarem de bases de dados que concentram publicações de excelência voltadas para a área da saúde. A seleção dos estudos publicados nas bases de dados foi compreendida entre os anos de 2001 a 2021, utilizando os descritores reconhecidos pelos DECs: “Endometriosis”, “Early Diagnosis”, “Infertility Female” e “Treatmet Alternatives”. Assim, obtivemos resultados de estudos que abordam aspectos envolvidos na dificuldade de se obter o diagnóstico precoce da endometriose, além dos tratamentos disponíveis. Evidenciamos que a endometriose ainda é uma doença de etiopatogenia incerta, e que essa incerteza contribui para a dificuldade de diagnóstico da doença, na qual a falta de informações se destaca como um dos principais fatores que dificultam o diagnóstico precoce da endometriose.

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Economic burden of deep infiltrating endometriosis of the bowel and the bladder in Germany: The statutory health insurance perspective

Cited by 5 publications

References 25 publications

Epidemiological profile of women with endometriosis: a retrospective descriptive study

Epidemiological profile of women with endometriosis: a retrospective descriptive study

Matrix metalloproteinases 3 polymorphism increases the risk of developing advanced endometriosis and infertility: A case-control study

Endometriose, dificuldades no diagnóstico precoce e a infertilidade feminina: Uma Revisão

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