Economic Analysis Of Evarrest® Sealant Matrix Compared With Standard Of Care In Severe Soft Tissue Surgical Bleeding: A United Kingdom Hospital Perspective

Abstract

unheated CO2 (U-CO2) in laparoscopic patients. Efficacy data were derived from a published randomised controlled trial reporting on the proportion of patients with hypothermia, a US database analysis of hypothermia patients for open surgery, and from an unpublished UK NHS before and after study of laparoscopic surgery patients. Other parameter inputs were obtained from published literature. Deterministic and probabilistic sensitivity analyses were conducted to assess the robustness of results. Scenario analyses were undertaken to explore structural uncertainty within the model. Results: The use of WH-CO2 dominated standard care, as it was both cost saving and generated greater QALYs, for both open and laparoscopic surgery patients over a one year time horizon. Results varied by the number of patients undergoing surgery per humidifier per year. Based on 250 patients using the humidifier each year over a five year lifetime of the humidifier, WH-CO2 dominated no insufflation in open surgery patients in 71% of model iterations and dominated U-CO2 in laparoscopic surgery in 98% of model iterations. WH-CO2 remained the cost-effective treatment option at a willingness-to-pay threshold of £20,000 per QALY throughout all scenario and sensitivity analyses considered, provided 10 or more patients used each humidifier over its life span. ConClusions: The analyses conducted suggest that based upon the currently available clinical evidence, WH-CO2 is a cost-effective use of resources for patients undergoing either open or laparoscopic colorectal surgery within the UK NHS.

Clinical effectiveness and versatility of a sealing hemostatic patch (HEMOPATCH) in multiple surgical specialties

“…Cost studies of a novel fibrin sealant matrix, EVARREST, compared to standard of care have shown cost savings for hepatic surgery in a US hospital setting [8] and for soft tissue surgery in Italian, German, and UK hospital settings [69][70][71]. Similarly, a retrospective cost analysis of brain/cerebral surgery, cardiovascular surgery, and carotid endarterectomy using a US hospital database found lower resource utilization and costs associated with the use of SURGICEL advanced products [72].…”

A PEG-Based Hydrogel for Effective Wound Care Management

“…For example, the use of sutures for wound closure is time-consuming, may cause further tissue damage, may result in infection, and does not provide immediate sealing to prevent leakage of bodily fluids or exposure to air. The application of adhesives is a convenient alternative method for wound closure because of the simple implementation procedure, shorter healing time, less pain for patients, and lack of need for removal 7 . It is extremely challenging to achieve strong adhesion in soft tissues while minimizing toxicity, tissue damage, and other side effects caused by the sealing materials.…”

A Prospective, Randomized, Phase III Study to Evaluate the Efficacy and Safety of Fibrin Sealant Grifols as an Adjunct to Hemostasis as Compared to Cellulose Sheets in Hepatic Surgery Resections

“…14 Although it is accepted that fibrin sealants can be effective as adjunct therapies to achieve hemostasis during liver resections, there seems to be weak evidence on the efficacy of fibrin sealants in reducing the use of blood products, postoperative complications and mortality. 32,33 The cost-savings efficacy of local hemostatic agents has been also object of debate, with reports in favor 34,35 or against. 36…”