Ecology of Ixodes Dammini-Borne Human Babesiosis and Lyme Disease

Spielman, Andrew; Wilson, Mark L.; Levine, Jay F.; Piesman, Joseph

doi:10.1146/annurev.en.30.010185.002255

Cited by 468 publications

(319 citation statements)

References 48 publications

Supporting

Mentioning

312

Contrasting

Unclassified

Order By: Relevance

“…Although the current range of the white-tailed deer contains the entire expected distribution of I. scapularis with the exception of Newfoundland (Wilson and Ruff 1999), it is host population density that will determine whether an introduction of I. scapularis can result in population maintenance (Spielman, Wilson et al 1985). Subsequently, white-tailed deer is more likely influenced by shifts in vegetation distribution rather than by thermal conditions due to their physiological tolerance to heat load (Johnston and Schmitz 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Increase in temperature may result in the northward expansion of the southern hosts of I. scapularis. In the South, host composition is believed to be dominated by lizard species (Oliver, Cummins et al 1993), which are either inefficient or incompetent reservoirs of infection for immature ticks resulting in overall low infection rates (Spielman, Wilson et al 1985). The movement of these hosts northward could result in the disruption of the enzootic cycle of B. burgdorferi in the North reducing the public health…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Climate Change on Lyme Disease Risk in North America

2005

View full text Add to dashboard Cite

An understanding of the influence of climate change on Ixodes scapularis, the main vector of Lyme disease in North America, is a fundamental component in assessing changes in the spatial distribution of human risk for the disease. We used a climate suitability model of I. scapularis to examine the potential effects of global climate change on future Lyme disease risk in North America. A climatebased logistic model was first used to explain the current distribution of I. scapularis in North America. Climate change scenarios were then applied to extrapolate the model in time and produce forecasts of vector establishment. The spatially modeled relationship between I. scapularis presence and large-scale environmental data generated the current pattern of I. scapularis across North America with an accuracy of 89% (p<0.0001). Extrapolation of the model revealed a significant expansion of I. scapularis north into Canada with an increase in suitable habitat of 213% by the 2080's. Climate change will also result in a retraction of the vector from southern United States, and movement into the central United States. This report predicts the effect of climate change on Lyme disease risk and specifically forecasts the emergence of a tick-borne infectious disease in Canada. Our modeling approach could thus be used to outline where future control strategies and prevention efforts need to be applied.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Climate Change on Lyme Disease Risk in North America

2005

View full text Add to dashboard Cite

show abstract

“…For example, Borrelia burgdorferi sensu lato, which causes Lyme disease, is vectored by several different species of tick and is maintained by systemic infections in an array of hosts from three classes of vertebrate (Spielman et al 1985;Matuschka et al 1992). Altered abundance of any of these biotic components may cause changes in vector infection prevalence for a given disease and, therefore, the risk of exposure for a given host, such as humans (Matuschka and Spielman 1986;Ostfeld and Keesing 2000).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Implications of Host Biodiversity and Vector Biology: Key Insights from Simple Models

Dobson

Auld

2016

The American Naturalist

View full text Add to dashboard Cite

Online enhancement: zip file. Dryad data: http://dx.doi.org/10.5061/dryad.t24pq.abstract: Models used to investigate the relationship between biodiversity change and vector-borne disease risk often do not explicitly include the vector; they instead rely on a frequency-dependent transmission function to represent vector dynamics. However, differences between classes of vector (e.g., ticks and insects) can cause discrepancies in epidemiological responses to environmental change. Using a pair of disease models (mosquito-and tick-borne), we simulated substitutive and additive biodiversity change (where noncompetent hosts replaced or were added to competent hosts, respectively), while considering different relationships between vector and host densities. We found important differences between classes of vector, including an increased likelihood of amplified disease risk under additive biodiversity change in mosquito models, driven by higher vector biting rates. We also draw attention to more general phenomena, such as a negative relationship between initial infection prevalence in vectors and likelihood of dilution, and the potential for a rise in density of infected vectors to occur simultaneously with a decline in proportion of infected hosts. This has important implications; the density of infected vectors is the most valid metric for primarily zoonotic infections, while the proportion of infected hosts is more relevant for infections where humans are a primary host.

show abstract

“…The aetiological agent of Lyme disease, Borrelia burgdorferi sensu lato, is transmitted mainly by ticks of the Ixodes ricinus complex in North America and Europe [4,5] and by I. persulcatus and I. ovatus ticks in the countries of Far East Asia [6][7][8]. Although a human case of Lyme disease had been reported in Taiwan [9] and Borrelia spirochaetes were also isolated from rodents in the Taiwan area [10], the genetic diversity of spirochaetes as well as the tick vectors responsible for transmission in Taiwan need to be established.…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis of the outer surface protein C gene of Lyme disease spirochaetes (Borrelia burgdorferi sensu lato) isolated from rodents in Taiwan

Shih

Chao

2002

Journal of Medical Microbiology

View full text Add to dashboard Cite

The outer surface protein C gene (ospC) of Lyme disease spirochaetes (Borrelia burgdorferi sensu lato) was analysed for the first time in Taiwan. The genetic identities of these Taiwan isolates (TWKM1-7) were determined by restriction fragment length polymorphism (RFLP) analysis and sequence similarities of the PCR-amplified ospC gene amplicons. After cleavage by nuclease Dra I, differential fragment patterns of PCRamplified ospC DNA in relation to different genospecies of Lyme disease spirochaetes were observed and all of these Taiwan isolates were genetically aff iliated to the genospecies of B. burgdorferi sensu stricto. The phylogenetic analysis on the sequence similarity of these Taiwan isolates revealed a highly homogeneous genotype, ranging from 99.3% to 100%, within the genospecies of B. burgdorferi sensu stricto and was distinguished from other genospecies of Borrelia isolates. The sequence similarity analysis also revealed the high sequence variability of the ospC gene among Borrelia strains that belong to the same genospecies but were isolated from different biological and geographical sources. Thus, these results provide the first investigation on the genetic identity of the ospC gene of these Taiwan isolates and show that these Taiwan isolates were closely related genetically to the genospecies of B. burgdorferi sensu stricto.

show abstract

Ecology of Ixodes Dammini-Borne Human Babesiosis and Lyme Disease

Cited by 468 publications

References 48 publications

Effect of Climate Change on Lyme Disease Risk in North America

Effect of Climate Change on Lyme Disease Risk in North America

Epidemiological Implications of Host Biodiversity and Vector Biology: Key Insights from Simple Models

Genetic analysis of the outer surface protein C gene of Lyme disease spirochaetes (Borrelia burgdorferi sensu lato) isolated from rodents in Taiwan

Contact Info

Product

Resources

About