Ecology of Helicobacter pylori in the human stomach.

Blaser, Martin J.

doi:10.1172/jci119588

Cited by 242 publications

(189 citation statements)

References 27 publications

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“…Helicobacter pylori has been associated with chronic gastritis, gastric and duodenal ulcers and gastric cancer (Blaser et al, 1997;Ernst and Gold, 2000). Asian-Pacific guidelines on gastric cancer prevention recommend screening for and eradicating H. pylori in high-risk populations (Fock et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

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Status of Helicobacter pylori Infection among Migrant Workers in Shijiazhuang, China

Ma²,

Wang³

2012

Asian Pacific Journal of Cancer Prevention

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Background: Helicobacter pylori infection leads to many upper gastrointestinal diseases. Migrant workers are the main part of floating population in China. However, up to now, their health status has not been a focus of attention. Methods: In order to assess the status of H. pylori infection among migrant workers in Shijiazhuang, over five years we interviewed 324 individuals between 2007 and 2011. Each underwent a rapid urease test to identify H. pylori infection and socio-demographic indicators were collected using a survey questionnaire. Results: Our results showed that family income (P = 0.003), dietetic hygiene (P = 0.005), education (P = 0.004) and marital status (P = 0.007) were associated with H. pylori infection. Conclusion: We found that migrant workers had little basic knowledge of H. pylori and their prevalence of infection remains high. Therefore, we need to promote education and awareness of H. pylori and to ensure access to diagnosis and treatment for infected workers.

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Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori is an important etiologic agent of gastritis, peptic ulcers, and gastric cancer (Blaser et al, 1997;Ernst and Gold, 2000). In 1994, the International Agency for Research on Cancer categorized H. pylori infection as a group I carcinogen (IARC, 1994).…”

Section: Introductionmentioning

confidence: 99%

Status of Helicobacter pylori Infection among Migrant Workers in Shijiazhuang, China

Ma²,

Wang³

2012

Asian Pacific Journal of Cancer Prevention

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“…It is protected from this acidic milieu via the liberation of urease. This enzyme converts urea, pumped into the cell via a pH-gated urea channel, to carbon dioxide and ammonia [66]. H. pylori displays significant genetic diversity due to ongoing DNA mutation during colonization of a specific host [2,67,68].…”

Section: About H Pylorimentioning

confidence: 99%

Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature

et al. 2005

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Eradication of Helicobacter pylori (H. pylori ) from the gastric mucosa has been associated with improvement of several systemic diseases, including immune thrombocytopenic purpura (ITP). Over the last 5 years, several studies have reported improved platelet counts in H. pylori-positive ITP patients following standard triple H. pylori eradication therapy. Review of published studies in which eradication of H. pylori has been performed in the ITP population indicates an overall response rate of 52% in 193 subjects in whom H. pylori was eradicated. Cohorts from Japan and Italy report higher response rates. There is no established mechanism to explain how this organism, which does not invade the gastric mucosa, could be implicated in the pathogenesis of this immune-based platelet disorder. Several theories including molecular mimicry, platelet aggregation, and immunomodulatory effects of macrolides have been proposed to explain the platelet response to anti-H. pylori therapy. Large randomized-controlled studies enrolling patients from various ethnic backgrounds will be necessary to determine the response rate and mechanism of response and to gain a better understanding of the pathogenesis of ITP. Am.

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Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors

Yakoob¹,

Rasool²,

Abbas³

et al. 2008

WJG

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H pylori is a spiral gram negative microaerophilic bacterium that infects the human gastric mucosa and is associated with gastritis, gastroduodenal ulcer disease, gastric carcinoma and mucosal associated lymphoid tissue lymphoma [1,2] . The prevalence of H pylori is high in developing countries. A recent study revealed an early colonization/infection of infants with H pylori and a prevalence of 67% at 9 mo of age in a peri-urban community in Karachi, Pakistan [3] . H pylori serology was positive in 58% of our general population in a previous study but is likely to actually be higher [4] . Currently, several diagnostic tests of varying sensitivity and specificity are available for determining the presence of H pylori, which include rapid urease test (RUT), histology, culture, urea breath test (UBT), and serology. Isolation of H pylori from gastric biopsy specimens constitutes the most specific way to establish the diagnosis of infection and to study the genotype of the infecting strains, however, it is a time consuming process. RUT and histology are still commonly used for the diagnosis of H pylori infection in our country as other modalities of H pylori testing, such as UBT and facilities for H pylori stool antigen tests, are not widely available.In Pakistan, self-prescription is common and medications are available over the counter without prescriptions [5] . It is known that acid reducing drugs; e.g, proton pump inhibitor (PPI), histamine-2 receptor blocker (H2RB), antibiotics and bismuth compounds reduce the sensitivity and specificity of the diagnostic tests for H pylori [6,7] . In our previous studies, we demonstrated that histology is comparatively less affected by PPI than RUT [8,9] . Polymerase chain reaction (PCR) is a highly

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Ecology of Helicobacter pylori in the human stomach.

Cited by 242 publications

References 27 publications

Status of Helicobacter pylori Infection among Migrant Workers in Shijiazhuang, China

Status of Helicobacter pylori Infection among Migrant Workers in Shijiazhuang, China

Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature

Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors

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