Ecology and Epidemiology of Newcastle Disease

Alexander, D. J.

doi:10.1007/978-88-470-0826-7_2

Cited by 49 publications

(53 citation statements)

References 42 publications

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“…The highest vaccine dose (0.2 mL) induced a positive response in week 1 after treatment, with titers over 1/ 16; this response remained significantly different from controls from week 4 until week 6, as found by Lloyd and Wernery (2008) in hybrid falcons. Both lower doses of vaccine (0.05 and 0.1 mL) followed the same pattern as described for the highest dose, but the effects were not detectable at week 1 after vaccination and titers remained close to 1/16, which is normally considered as the positive threshold for the diagnosis of exposure to NDV (Alexander, 2009). …”

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confidence: 54%

“…Newcastle disease virus (NDV) is a globally distributed avian paramyxovirus that causes highly contagious disease and represents a severe problem for the poultry industry (Alexander, 2009). Few studies have been performed on the specific immune response to NDV, especially in wild populations and nonmodel species (Seal et al, 2000).…”

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confidence: 99%

“…The HI test is a classic indirect diagnostic assay that is widely used and serves as a gold standard for detecting NDV antibodies in birds (Alexander, 2009). The concentration of NDV antibodies was determined by adding 4 hemagglutinin units of HIPRAVIARH-CLON (E.Newcastle, clon CL/79) antigen to test sera sequentially diluted from 1:2 to 1:640.…”

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confidence: 99%

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Immune Response to Newcastle Disease Virus Vaccination in a Wild Passerine

Broggi

García

Miranda

et al. 2013

Journal of Wildlife Diseases

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ABSTRACT:We studied the immune response of wild House Sparrows (Passer domesticus) experimentally challenged with different doses of inactivated Newcastle disease virus (NDV) vaccine. We evaluated within-individual cellmediated and humoral responses in birds kept in outdoor aviaries, over a 6-wk period. Nonbreeding adult House Sparrows developed a significant humoral response to NDV experimental vaccination within 1 wk postchallenge, as measured by hemagglutination inhibition assay; values increased until week 4 and persisted until week 6. Differences among treatments appeared by week 1, with individuals challenged with the highest dose (0.2 mL) eliciting a higher humoral response than the rest (n518). By week 4, all individuals vaccinated displayed an increased humoral response, with individuals challenged with the highest dose remaining significantly above responses of individuals vaccinated with the middle dose (0.1 mL, n514), but not the lowest dose (0.05 mL, n515). The middle and lowest dose responded similarly and significantly different from controls (n523). Differences persisted through week 6 postchallenge. Cellmediated responses were independent of the experimental treatment. All individuals experienced a rise in granulocyte concentration, whereas lymphocyte and monocyte concentrations decreased, most likely as a result of captivity. Adult wild House Sparrows immunochallenged with inactivated NDV vaccine developed a specific humoral response, highlighting the utility of this technique in immunologic and evolutionary ecology studies in wild birds.

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confidence: 54%

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Immune Response to Newcastle Disease Virus Vaccination in a Wild Passerine

Broggi

García

Miranda

et al. 2013

Journal of Wildlife Diseases

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“…This is unlike the situation in racing, farmed and feral pigeons, in which a panzootic caused exclusively by ND viruses of lineage 4b has continued for about 30 years (Vindevogel & Duchatel, 1988;Aldous et al, 2004;Alexander, 2009). The viruses isolated from game birds appear generally to represent geographically and temporally contemporaneous viruses affecting chickens, turkeys and/or other poultry.…”

Section: Resultsmentioning

confidence: 95%

“…Kaleta & Baldauf (1988) reviewed NDV isolations from all bird species and recorded that NDV infections have been established and detected in at least 241 species of birds, representing 27 of the 50 orders of the class Aves. It would seem probable that all birds are likely to be susceptible to infection with this virus (Alexander, 2009).…”

Section: Introductionmentioning

confidence: 99%

A molecular epidemiological investigation of avian paramyxovirus type 1 viruses isolated from game birds of the orderGalliformes

et al. 2010

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The partial (370 nucleotides) fusion gene sequences of 55 avian paramyxovirus type 1 (APMV-1) isolates were obtained. Included were 41 published sequences, of which 16 were from strains of APMV-1 of previously determined lineages included as markers for the data analysed and 25 were from APMV-1 viruses isolated from game birds of the order Galliformes. In addition, we sequenced a further 14 game bird isolates obtained from the repository at the Veterinary Laboratories Agency. The game bird isolates had been obtained from 17 countries, and spanned four decades. Earlier studies have shown that class II APMV-1 viruses can be divided into at least 15 lineages and sub-lineages. Phylogenetic analysis revealed that the 39 game bird isolates were distributed across 12 of these sub-lineages. We conclude that no single lineage of Newcastle disease viruses appears to be prevalent in game birds, and the isolates obtained from these hosts reflected the prevailing, both geographically and temporally, viruses in poultry, pigeons or wild birds.

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