Ecological study of ambient air pollution exposure and mortality of cardiovascular diseases in elderly

Dehghani, Samaneh; Vali, Mohebat; Jafarian, Arian; Oskoei, Vahide; Maleki, Zahra; Hoseini, Mohammad

doi:10.1038/s41598-022-24653-0

Cited by 16 publications

(4 citation statements)

References 94 publications

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“…In the present study, we found that PM 2.5 and PM 10 were the most important variables affecting multiple maternal blood markers. Similar results were also observed in previous studies that chronic exposure to higher levels of air pollutants (PM 1 , PM 2.5 , PM 10 , and NO 2 ) was associated with increased platelet size (Hou et al 2020 ), and in addition to systemic inflammation (Ferrucci and Fabbri 2018 ), the pro-thrombotic pathway induced by particulate PM may also be an important biological pathway contributing to cardiovascular risk (Brook and Rajagopalan 2010 ; Dehghani et al 2022b ; Rajagopalan et al 2018 ). Results from rodent model studies suggest that exposure to airborne PM may lead to platelet aggregation and arterial thrombosis (Hadei and Naddafi 2020 ).…”

Section: Resultssupporting

confidence: 88%

Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China

Hu,

Xu,

Yang

et al. 2023

Environ Sci Pollut Res

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Antenatal exposure to air pollutants is thought to be associated with a variety of maternal blood markers as well as adverse birth outcomes. However, the dysgenic influence of air pollutants on the antiphospholipid syndrome (APS) in mothers and their pregnancy outcomes remains unclear. In the current study, 371 mother-infant pairs (189 healthy: 182 APS) from Nanjing Maternal and Child Health Hospital as well as air pollutants concentration from their living environment were used to investigate correlations between air pollution with maternal blood indicators and fetal birth weight in the groups of APS and healthy mothers. Generalized linear model was used to evaluate the contributions of air pollutant exposure during pregnancy to the blood indicators variation. The relationships between birth weight with specific air pollutant and blood index were analyzed using ridge regression. Results showed that APS fetal birth weight was significantly impacted by air pollutant exposure during pregnancy, in particular, the birth weight decreased significantly along with increasing fine particulate matter 2.5 (PM2.5) and fine particulate matter 10 (PM10) exposure concentrations throughout pregnancy. In contrast, birth weight increased significantly with sulfur dioxide (SO2) exposure. In addition, APS-related blood indicators comprised of platelet distribution width (PDW), total bilirubin (TBIL), mean platelet volume (MPV), platelet-larger cell ratio (P_LCR), homocysteine (HCY), alkaline phosphatase (ALP), direct bilirubin (DBIL), basophilic granulocyte (BAS), platelet thrombocytocrit (PCT), preprandial glucose levels (OGTT0), monocytes (MON), and monocytes ratio (MON_ratio) were also strongly related with prenatal exposure to PM2.5 and PM10, in which PDW levels showed most strongly negative impaction on fetal birth weight. Together, we showed that prenatal exposure to air pollutant (PM2.5 and PM10) may exacerbate the poor birth outcomes of low birth weight by impacting APS maternal blood indicators especially for PDW.

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Section: Resultssupporting

confidence: 88%

Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China

Hu,

Xu,

Yang

et al. 2023

Environ Sci Pollut Res

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“…Previously, mixed results have been found regarding the relationship between O 3 exposure and cardiovascular outcomes. For example, ecological study suggested a positive correlation between exposure to ambient O 3 and mortality of cardiovascular disease among the elderly in the Middle East [ 50 ], and several recent large cohort studies in the US and China showed that long-term exposure to O 3 was positively and monotonically related to cardiovascular mortality [ 5 , 51 , 52 ], whereas null or even negative associations were also reported in cohorts from France, Denmark, and the UK [ 53 – 55 ]. Since hypertension is one of the most important risk factors for various cardiovascular outcomes, the non-linear shape of the relationship between O 3 exposure and hypertension might indicate the presence of non-linear associations between O 3 exposure and other cardiovascular outcomes.…”

Section: Discussionmentioning

confidence: 99%

Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort

Hu,

Xu,

et al. 2023

BMC Public Health

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Background There is limited longitudinal evidence on the hypertensive effects of long-term exposure to ambient O3. We investigated the association between long-term O3 exposure at workplace and incident hypertension, diastolic blood pressure (DBP), systolic blood pressure (SBP), pulse pressure (PP), and mean arterial pressure (MAP) in general working adults. Methods We conducted a cohort study by recruiting over 30,000 medical examination attendees through multistage stratified cluster sampling. Participants completed a standard questionnaire and comprehensive medical examination. Three-year ambient O3 concentrations at each employed participant’s workplace were estimated using a two-stage machine learning model. Mixed-effects Cox proportional hazards models and linear mixed-effects models were used to examine the effect of O3 concentrations on incident hypertension and blood pressure parameters, respectively. Generalized additive mixed models were used to explore non-linear concentration-response relationships. Results A total of 16,630 hypertension-free working participants at baseline finished the follow-up. The mean (SD) O3 exposure was 45.26 (2.70) ppb. The cumulative incidence of hypertension was 7.11 (95% CI: 6.76, 7.47) per 100 person-years. Long-term O3 exposure was independently, positively and non-linearly associated with incident hypertension (Hazard ratios (95% CI) for Q2, Q3, and Q4 were 1.77 (1.34, 2.36), 2.06 (1.42, 3.00) and 3.43 (2.46, 4.79), respectively, as compared with the first quartile (Q1)), DBP (β (95% CI) was 0.65 (0.01, 1.30) for Q2, as compared to Q1), SBP (β (95% CI) was 2.88 (2.00, 3.77), 2.49 (1.36, 3.61) and 2.61 (1.64, 3.58) for Q2, Q3, and Q4, respectively), PP (β (95% CI) was 2.12 (1.36, 2.87), 2.03 (1.18, 2.87) and 2.14 (1.38, 2.90) for Q2, Q3, and Q4, respectively), and MAP (β (95% CI) was 1.39 (0.76, 2.02), 1.04 (0.24, 1.84) and 1.12 (0.43, 1.82) for Q2, Q3, and Q4, respectively). The associations were robust across sex, age, BMI, and when considering PM2.5 and NO2. Conclusions To our knowledge, this is the first cohort study in the general population that demonstrates the non-linear hypertensive effects of long-term O3 exposure. The findings are particularly relevant for policymakers and researchers involved in ambient pollution and public health, supporting the integration of reduction of ambient O3 into public health interventions.

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“…Air pollution's effects can be severe, including respiratory problems, cardiovascular disease, and premature death. The problem of protecting and restoring the environment is currently the main one of the essential tasks of science, the development of which is stimulated in all countries of the world [1]. Accurate measurement of air pollution is crucial for understanding the extent of the problem and developing effective control strategies.…”

Section: Dariya Bissengaliyevamentioning

confidence: 99%

Determination of the Reliability of Air Pollution Measurement Data Based on Vehicular Emission Recognized as Concomitant in Astana

Bissengaliyeva,

Amanzholov,

Rakhimkul

et al. 2023

sjaitu

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Air pollution is a primary global concern due to its adverse effects on human health and the environment. Accurate air pollution measurement is crucial for developing effective control strategies and evaluating their impact. In Astana, vehicular emissions are recognized as a significant contributor to air pollution. This study aims to determine the reliability of air pollution measurement data in Astana by examining the impact of vehicular emissions on air quality to establish the accuracy of air pollution measurement methods in the city. The study will use a combination of monitoring and modeling techniques to quantify the contribution of vehicular emissions to air pollution in Astana. The monitoring component will involve the deployment of air quality monitoring stations throughout the city to measure levels of pollutants such as particulate matter (PM). The modeling component will use air dispersion models to simulate the dispersal of pollutants from vehicular emissions and predict their concentration levels in different parts of the city. The results of this research will provide insights into the effectiveness of existing air pollution control strategies and may inform future efforts to improve air quality in Astana. Based on the collected data for a certain period, a comparative table is built describing the difference between the actual data from the collection points of air emission indicators. The article will likely interest researchers and policymakers concerned with air pollution and its effects on human health and the environment. The critical point of the article is that air quality is affected not only by transport but also by other emissions.

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Ecological study of ambient air pollution exposure and mortality of cardiovascular diseases in elderly

Cited by 16 publications

References 94 publications

Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China

Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China

Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort

Determination of the Reliability of Air Pollution Measurement Data Based on Vehicular Emission Recognized as Concomitant in Astana

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