Ecological risk assessment for perfluorohexanesulfonic acid (PFHxS) in soil using species sensitivity distribution (SSD) approach

Liu, Yanju; Samarasinghe, Samarasinghe Vidane Arachchige Chamila; Qi, Fang; Carles, Sandra; Richmond, William R.; Dong, Zhaomin; Naidu, Ravi

doi:10.1016/j.jhazmat.2022.129667

Cited by 6 publications

(2 citation statements)

References 53 publications

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“…Clearly, both models refute the possibility of an adaptively compensatory response in the low-dose zone, typically referred to doses below the zero-equivalent point (ZEP) of hormesis . With the increasing research attention to environmentally realistic scenarios, the detection and characterization of low-dose effects, as modeled by hormesis, have gradually become the scientific mainstream. , Furthermore, the SSD is a widely used standard approach for ERA, which improves the statistical confidence and assessment reliability by combining toxicological data from different sensitive species at multiple trophic levels . However, the SSD is essentially an S-shaped dose–response model and thus may also fail to capture the nature of dose–responses in the low-dose zone .…”

Section: Resultsmentioning

confidence: 99%

“…16,34 Furthermore, the SSD is a widely used standard approach for ERA, which improves the statistical confidence and assessment reliability by combining toxicological data from different sensitive species at multiple trophic levels. 59 However, the SSD is essentially an S-shaped dose−response model and thus may also fail to capture the nature of dose−responses in the low-dose zone. 60 Thus, there are great practical significance and environmental implications to place hormesis in realistic scenarios and establish empirical quantitative frameworks to indicate the subthreshold effects.…”

Section: Hormetic Amplitudes and Drivingmentioning

confidence: 99%

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Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment

Sun,

Ji,

et al. 2024

Environ. Sci. Technol.

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Globally implemented ecological risk assessment (ERA) guidelines marginalize hormesis, a biphasic dose−response relationship characterized by low-dose stimulation and high-dose inhibition. The present study illuminated the promise of hormesis as a scientific dose−response model for ERA of per-and polyfluoroalkyl substances (PFAS) represented by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). A total of 266 hormetic dose−response relationships were recompiled from 1237 observations, covering 30 species from nine representative taxonomic groups. The standardized hormetic amplitudes followed the log-normal probability distribution, being subject to the limits of biological plasticity but independent of stress inducers. The SHapley Additive exPlanations algorithm revealed that the target endpoint was the most important variable explaining the hormetic amplitudes. Subsequently, quantitative frameworks were established to incorporate hormesis into the predicted no-effect concentration levels, with a lower induction dose and a zero-equivalent point but a broader hormetic zone for PFOS. Realistically, 10,117 observed concentrations of PFOA and PFOS were gathered worldwide, 4% of which fell within hormetic zones, highlighting the environmental relevance of hormesis. Additionally, the hormesis induction potential was identified in other legacy and emerging PFAS as well as their alternatives and mixtures. Collectively, it is time to incorporate the hormesis concept into PFAS studies to facilitate more realistic risk characterizations.

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