Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet’s Qamdo City, China

Zha, Xinjie; Xing, Guangfu

doi:10.1038/s41598-019-39792-0

Cited by 13 publications

(16 citation statements)

References 37 publications

(32 reference statements)

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“…The relationship between KBD and selenium (Se) has always been a hot topic in the environmental etiology of KBD. Numerous studies have demonstrated that the prevalence of KBD is closely related to the low Se environment [12][13][14][15][16][17], and Se supplementation can effectively control and prevent KBD [18][19][20][21]. Nevertheless, there were still some studies questioning this Se deficiency etiological hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Health Loss from Kashin-Beck Disease and Its Relationship with Environmental Selenium in Qamdo District of Tibet, China

Wang

Zhao

Yang

et al. 2020

IJERPH

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Kashin-Beck Disease (KBD) is one of major endemic diseases in China. In this study, we estimated the health loss from KBD in Qamdo district of Tibet using the years lived with disability (YLD) metric and investigated the influence of environmental selenium (Se) on it by multiple regression model. The results showed that YLD rates produced a different ranking of health loss of KBD from that produced by prevalence rates between Basu and Luolong County, with higher health loss from KBD (43.61 YLD/1000) but lower prevalence (17.86%) in Basu County. YLD rates in two counites were both highest for the 45–64 years age group. Compared with the prevalence rate, the YLD rate had a closer relation to environmental Se and was significantly negatively correlated with Se in both soil and highland barley. The multiple linear regression further revealed that Se contents in cultivated soil and highland barley were main influencing factors for the health loss of KBD, which could explain 90.5% of the variation in YLD rates. The information obtained highlights the significance of the YLD metric in exploring the environmental etiology of KBD and provides important information on which to base decisions on future prevention and control of endemic diseases.

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Section: Introductionmentioning

confidence: 99%

Assessing the Health Loss from Kashin-Beck Disease and Its Relationship with Environmental Selenium in Qamdo District of Tibet, China

Wang

Zhao

Yang

et al. 2020

IJERPH

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“…The first cases of Keshan disease (KD) were discovered over 80 years ago in Keshan County (Heilongjiang Province, north-eastern China) [ 60 ]. The disease was characterized by congestive cardiomyopathy and affected children aged 2–7 years and women of reproductive age [ 61 ], whereas Kashin-Beck disease (KBD) occurs most frequently in Tibet [ 62 ] and begins in childhood around age five [ 63 , 64 ]. KBD is characterized by osteoarthritis, leading to the degradation of cartilage in the upper and lower limbs [ 63 ].…”

Section: Dietary Intake Of Seleniummentioning

confidence: 99%

Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity

et al. 2021

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This review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activity of selenium, which it performs mainly through selenoproteins, is discussed. These specific proteins are responsible for thyroid hormone management, fertility, the aging process, and immunity, but their key role is to maintain a redox balance in cells. Furthermore, taking into account world news and the current SARS-CoV-2 virus pandemic, the impact of selenium on the course of COVID-19 is also discussed. Another worldwide problem is the number of new cancer cases and cancer-related mortality. Thus, the last part of the article discusses the impact of selenium on cancer risk based on clinical trials (including NPC and SELECT), systematic reviews, and meta-analyses. Additionally, this review discusses the possible mechanisms of selenium action that prevent cancer development.

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“…The health loss of KBD is directly related to the severity of KBD. Selenium (Se) deficiency is acknowledged as an important environmental risk factor for the onset of KBD [ 3 , 13 , 14 ]. A great number of studies have reported the close link between the prevalence of KBD and low-Se environment [ 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Spatial distribution and determinants of health loss from Kashin-Beck disease in Bin County, Shaanxi Province, China

Wang

et al. 2021

BMC Public Health

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Background Kashin-Beck disease (KBD) is one of the major endemic diseases in China, which severely impacts the physical health and life quality of people. A better understanding of the spatial distribution of the health loss from KBD and its influencing factors will help to identify areas and populations at high risk so as to plan for targeted interventions. Methods The data of patients with KBD at village-level were collected to estimate and analyze the spatial pattern of health loss from KBD in Bin County, Shaanxi Province. The years lived with disability (YLDs) index was applied as a measure of health loss from KBD. Spatial autocorrelation methodologies, including Global Moran’s I and Local Moran’s I, were used to describe and map spatial clusters of the health loss. In addition, basic individual information and environmental samples were collected to explore natural and social determinants of the health loss from KBD. Results The estimation of YLDs showed that patients with KBD of grade II and patients over 50 years old contributed most to the health loss of KBD in Bin County. No significant difference was observed between two genders. The spatial patterns of YLDs and YLD rate of KBD were clustered significantly at both global and local scales. Villages in the southwestern and eastern regions revealed higher health loss, while those in the northern regions exhibited lower health loss. This clustering was found to be significantly related to organically bound Se in soil and poverty rate of KBD patients. Conclusions Our results suggest that future treatment and prevention of KBD should focus on endemic areas with high organically bound Se in soil and poor economic conditions. The findings can also provide important information for further exploration of the etiology of KBD.

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Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet’s Qamdo City, China

Cited by 13 publications

References 37 publications

Assessing the Health Loss from Kashin-Beck Disease and Its Relationship with Environmental Selenium in Qamdo District of Tibet, China

Assessing the Health Loss from Kashin-Beck Disease and Its Relationship with Environmental Selenium in Qamdo District of Tibet, China

Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity

Spatial distribution and determinants of health loss from Kashin-Beck disease in Bin County, Shaanxi Province, China

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