Ecocardiografia de pacientes talassêmicos sem insuficiência cardíaca em tratamento com transfusões sanguíneas e quelação

Rodrigues, Alexandre; Guimarães-Filho, Fábio Villaça; Braga, J.; Rodrigues, Cássia Spínola Custódio; Waib, Paulo H.; Fabron-Junior, Antonio; Tan, Doralice Marvulle; França, Ana Cristina C. V.; Okoshi, Marina Politi; Okoshi, Katashi

doi:10.1590/s0066-782x2013005000001

Cited by 14 publications

(12 citation statements)

References 37 publications

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“…A recent study demonstrated a significant correlation between iron overload in the liver and pulmonary artery systolic pressure independent of LV filling pressures . conventional Doppler echocardiography and tissue Doppler allow for identifying left ventricular diastolic alterations in asymptomatic patients with thalassemia major (Rodrigues et al, 2013). In comparison, another investigation consisting 110 patients with thalassemia intermedia, overall mean ferritin levels were 1657±1477ng/ml which was lower than what we found in the present study (2419.13±1772.65ng/ml) that could be the result of less frequent and incorrect use of iron chelation in our patients (Aessopos et al, 2001).…”

Section: Discussioncontrasting

confidence: 83%

Evaluation of the Correlation between Echocardiographic Findings and Serum Ferritin in Thalassemia Major Patients

Khalilian¹,

Moghaddar²,

Emami-Moghadam³

et al. 2016

GJHS

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Introduction: Thalassemia is a disorder that affects beta globin gene production and the resultant need for erythrocyte transfusions puts the patient at risk for iron loading, especially cardiac iron loading. Cardiac complications are the most serious ones accompanied by morbidity and mortality. The most harm to the heart is caused by iron overload. Ferritin is generally associated with the amount of stored iron in the body. The aim of this study was to investigate the relationship between echocardiographic findings and serum ferritin level. Materials & Methods:107 patients with thalassemia major were enrolled in this prospective analytical study. Serum ferritin levels and echocardiographic findings (diastolic, systolic, pulmonary artery pressure, valvular dysfunctions) were assessed. The data were analyzed by spearman statistical test.Results: Serum ferritin levels of the thalassemia major patients in the study were 2419.13±1772.65 ng/ml. there wasn't any significant relationship between echocardiographic findings and serum ferritin level. Conclusion:Although our findings didn't support the association between ferritin level and echocardiographic data but we suggest serial cardiac assessment to prevent the effect of increasing iron on the heart.

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Section: Discussioncontrasting

confidence: 83%

Evaluation of the Correlation between Echocardiographic Findings and Serum Ferritin in Thalassemia Major Patients

Khalilian¹,

Moghaddar²,

Emami-Moghadam³

et al. 2016

GJHS

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“…In response to the letter, we appreciate the interest shown and comments made on our work 1. We hope that our data will stimulate new research especially in the field of biventricular diastolic function in individuals with thalassemia major.…”

mentioning

confidence: 84%

“…An E/E' ratio ≥4 had high sensitivity and specificity for predicting RA pressure ≥10 mm Hg in non-cardiac surgery intensive care unit patients 4 . The current study 1 did not evaluate RV diastolic function and RA volume. Further studies should be conducted to assess RA volume and RV tissue Doppler diastolic parameters such as tricuspid E/E' ratio.…”

mentioning

confidence: 88%

“…We read with great interest the article "Echocardiography in Thalassemic Patients on Blood Transfusions and Chelation without Heart Failure" written by Rodrigues et al 1 . They aimed to evaluate cardiac structure and function by conventional Doppler echocardiography and tissue Doppler imaging in patients with thalassemia major (TM) and no clinical evidence of heart failure.…”

mentioning

confidence: 99%

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Right Ventricular Diastolic Function in Patients with Thalassemia Major

Demırkol¹,

Balta²,

Çakar³

2013

Arquivos Brasileiros De Cardiologia

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“…A standard echocardiography system (General Electric Medical Systems, Vivid 3) was used to measure cardiac structures as previously described and following American Society of Echocardiography recommendations [17], [18], [19], [20]. All echocardiograms were performed by the same examiner (JMBBF).…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular changes in patients with non-severe Plasmodium vivax malaria

Alencar-Filho

Ferreira

Salinas

et al. 2016

IJC Heart & Vasculature

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BackgroundCardiovascular system involvement in patients with Plasmodium vivax malaria has been poorly addressed. The aim of this study was to evaluate cardiac structures and function, and serum markers of cardiovascular injury in patients with the non-severe form of vivax malaria in Manaus, Amazonas State, Brazil.Methods and resultsWe prospectively evaluated 26 patients with vivax malaria in an outpatient referral hospital and compared results with a control group of 25 gender- and age-matched healthy individuals. Patients underwent clinical evaluation, laboratory tests, and transthoracic echocardiography at first evaluation (day zero, D0) and seven days (D7) after malaria diagnosis. At D0 echocardiography showed higher left ventricular (LV) systolic diameter (28.8 ± 2.82 vs 30.9 ± 4.03 mm; p = 0.037) and LV diastolic volume (82.4 ± 12.3 vs 93.8 ± 25.9 ml; p = 0.05), and lower LV ejection fraction (Teicholz method: 73.2 ± 6.59 vs 68.4 ± 4.87%; p = 0.004) in patients compared to controls. Right ventricle (RV) fractional area change (54.7 ± 5.11 vs 50.5 ± 6.71%; p = 0.014) was lower, and RV myocardial performance index (0.21 ± 0.07 vs 0.33 ± 0.19; p = 0.007), and pulmonary vascular resistance (1.13 ± 0.25 vs 1.32 ± 0.26 Woods unit; p = 0.012) were higher in patients than controls. Patients presented higher serum levels of unconjugated bilirubin (0.24 ± 0.15 vs 1.30 ± 0.89 mg/dL; p < 0.001), soluble vascular cell adhesion molecule–1 (sVCAM-1; 453 ± 143 vs 1983 ± 880 ng/mL; p < 0.001), N-terminal prohormone brain natriuretic peptide (0.59 ± 0.86 vs 1.08 ± 0.81 pg/mL; p = 0.045), and troponin T (861 ± 338 vs 1037 ± 264 pg/mL; p = 0.045), and lower levels of plasma nitrite (13.42 ± 8.15 vs 8.98 ± 3.97 μM; p = 0.016) than controls. Most alterations had reversed by D7.ConclusionPatients with non-severe Plasmodium vivax malaria present subclinical reversible cardiovascular changes.

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Ecocardiografia de pacientes talassêmicos sem insuficiência cardíaca em tratamento com transfusões sanguíneas e quelação

Cited by 14 publications

References 37 publications

Evaluation of the Correlation between Echocardiographic Findings and Serum Ferritin in Thalassemia Major Patients

Evaluation of the Correlation between Echocardiographic Findings and Serum Ferritin in Thalassemia Major Patients

Right Ventricular Diastolic Function in Patients with Thalassemia Major

Cardiovascular changes in patients with non-severe Plasmodium vivax malaria

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