Eco-friendly UPLC-MS/MS analysis of possible add-on therapy for COVID-19 in human plasma: Insights of greenness assessment

El-Naem, Omnia A.; Saleh, Sarah S.

doi:10.1016/j.microc.2021.106234

Cited by 16 publications

(3 citation statements)

References 48 publications

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“…According to WHO, the number of COVID-19 confirmed cases exceeded 400 million cases by the beginning of the year 2022 [ 1 ]. Several pharmaceuticals including antibiotics have been repurposed for the management of COVID-19 by either resolving bacterial infections co-existing with COVID-19 or testing their potential antiviral activities [ 2 , 3 ]. The risk of environmental bioaccumulation of antibiotics may cause bacterial resistance, genotoxic effects, and endocrine disturbance [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Green wastewater treatment of repurposed COVID-19 therapy (levofloxacin) using synthesized magnetite pectin nanoparticles, comparison with mesoporous silica nanoparticles

El-Maraghy,

Saleh,

Ibrahim

et al. 2023

BMC Chemistry

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Rationale Antibiotics have been detected worldwide in the aquatic environment. Moreover, certain classes of antibiotics have been repurposed for the management of COVID-19, which increased their use and presence in wastewater. Their occurrence even in low concentrations leads to the development of antibiotic resistance. Methodology Magnetite pectin nanoparticles (MPNP) were fabricated and compared to an established model of mesoporous silica nanoparticles (MSNP). Our studied adsorbate is levofloxacin, a fluoroquinolone antibiotic, commonly used in managing COVID-19 cases. Results The influence of various factors affecting the adsorption process was studied, such as pH, the type and concentration of the adsorbent, contact time, and drug concentration. The results illustrated that the optimum adsorption capacity for antibiotic clearance from wastewater using MPNP was at pH 4 with a contact time of 4 h; while using MSNP, it was found to be optimum at pH 7 with a contact time of 12 h at concentrations of 10 µg/mL and 16 g/L of the drug and nanoparticles, respectively, showing adsorption percentages of 96.55% and 98.89%. Drug adsorption equilibrium data obeyed the Sips isotherm model. Discussion and conclusion HPLC assay method was developed and validated. The experimental results revealed that the MPNP was as efficient as MSNP for removing the antibacterial agent. Moreover, MPNP is eco-friendly (a natural by-product of citrus fruit) and more economic as it could be recovered and reused. The procedure was evaluated according to the greenness assessment tools: AGREE calculator and Hexagon-CALIFICAMET, showing good green scores, ensuring the process’s eco-friendliness.

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Section: Introductionmentioning

confidence: 99%

Green wastewater treatment of repurposed COVID-19 therapy (levofloxacin) using synthesized magnetite pectin nanoparticles, comparison with mesoporous silica nanoparticles

El-Maraghy,

Saleh,

Ibrahim

et al. 2023

BMC Chemistry

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“…Several efforts such as converting general assessment terms such as “good”, “moderate” and “bad” into numerical scores were performed to improve LCA and EIA assessments tools but were found to be time-consuming [ 14 , 15 ]. After the emergence of green analytical chemistry (GAC) [ 16 ], scientists worked toward developing greener approaches for analysis in light of these concepts [ 17 , 18 , 19 ]. However, the evaluation of the greenness of a procedure was merely descriptive, making the overall assessment of the procedure challenging because analytical procedures require several steps.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Novel Tool for Assessing the Environmental Impact of 3D Printing Technologies: A Pharmaceutical Perspective

2022

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Technological advancements have created infinite opportunities and rendered our life easier at several fronts. Nonetheless, the environment has suffered the aftermaths of modernization. Ironically, the pharmaceutical industry was found to be a significant contributor to environmental deterioration. To tackle this issue, continuous eco-evaluation of newly introduced technologies is crucial. Three-dimensional printing (3DP) is rapidly establishing its routes in different industries. Interestingly, 3DP is revolutionising the production of pharmaceuticals and is regarded as a promising approach for the fabrication of patient-centric formulations. Despite the increasing applications in the pharmaceutical field, tools that evaluate the environmental impacts of 3DP are lacking. Energy and solvent consumption, waste generation, and disposal are the main associated factors that present major concerns. For the first time, we are proposing a quantitative tool, the index of Greenness Assessment of Printed Pharmaceuticals (iGAPP), that evaluates the greenness of the different 3DP technologies used in the pharmaceutical industry. The tool provides a colour-coded pictogram and a numerical score indicating the overall greenness of the employed printing method. Validation was performed by constructing the greenness profile of selected formulations produced using the different 3DP techniques. This tool is simple to use and indicates the greenness level of the procedures involved, thereby creating an opportunity to modify the processes for more sustainable practices.

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“…The literature review revealed several analytical methods for the quantitative determination of bromhexine HCl. These methods include spectrophotometry [7], liquid chromategraphy [8] and gas chromatography [9], whereas lidocaine HCl analytical methods in the literature include spectrophotometry [10,11], electrochemical methods [12,13], HPLC [14,15], and GLC [16]. Oxytetracycline HCl literature survey revealed several methods including spectrophotometry [17], HPLC [18,19], and electrochemical methods [20,21].…”

Section: Introductionmentioning

confidence: 99%

Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations

et al. 2022

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This work describes a comparative study of two multivariate chemometric and univariate spectrophotometric methods for the determination of a ternary drug mixture containing oxytetracycline HCl, bromhexine HCl, and lidocaine HCl. All methods show high sensitivity and similar linearity range. Meanwhile, the chemometric method has the advantage of higher accuracy, higher specificity and better regression parameters. The two spectrophotometric methods are constant multiplication coupled with spectrum subtraction and successive ratio subtraction coupled with spectrum subtraction while the chemometric method used partial least square and principal component regression models. In addition, a spiking technique was used to increase the concentration of bromhexine HCl in the dosage form, allowing its determination despite its low contribution. Methods were successfully applied in the dosage form Oxyclear® veterinary injection in pure powder as well as in its pharmaceutical formulation. Statistical comparison showed no significant difference between the developed methods and the reference method.

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Eco-friendly UPLC-MS/MS analysis of possible add-on therapy for COVID-19 in human plasma: Insights of greenness assessment

Cited by 16 publications

References 48 publications

Green wastewater treatment of repurposed COVID-19 therapy (levofloxacin) using synthesized magnetite pectin nanoparticles, comparison with mesoporous silica nanoparticles

Green wastewater treatment of repurposed COVID-19 therapy (levofloxacin) using synthesized magnetite pectin nanoparticles, comparison with mesoporous silica nanoparticles

Development and Validation of a Novel Tool for Assessing the Environmental Impact of 3D Printing Technologies: A Pharmaceutical Perspective

Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations

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