Eco-friendly micellar ultra-performance liquid chromatography (UPLC) method for simultaneous determination of non-communicable diseases drugs in bulk powder, spiked human plasma and in individual dosage forms
Manal Fouad,
Noha Rashed,
Asmaa Hosameldin
Abstract:Green, simple and accurate micellar UPLC method was established and validated for quantitative determination of glimepiride, pioglitazone HCl, Valsartan and atorvastatin calcium trihydrate in bulk powder, tablets and spiked human plasma. Gradient separation was achieved on Kinetex 1.7µ C18 100A (2.1-mm × 50-mm) at ambient temperature using ecofriendly gradient mobile phase composed of a mixture of 0.05 M potassium dihydrogen phosphate buffer pH 5.00 (A) with 0.10M sodium dodecyl sulfate and isopropanol (15.00-… Show more
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