Eco-friendly curcumin-loaded nanostructured lipid carrier as an efficient antibacterial for hospital wastewater treatment

Shajari, Mozhgan; Rostamizadeh, Kobra; Shapouri, Reza; Taghavi, Lobat

doi:10.1016/j.eti.2020.100703

Cited by 25 publications

(14 citation statements)

References 32 publications

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“…Silica sol specimens (Si-1 and Si-2) with different particle sizes were synthesized by adjusting the content of NH 4 OH while generation of the silica sol as indicated in Table 1 . The polydispersity index (PDI) value can be used to evaluate the average uniformity of a particle or nanoparticle dispersion ( Clayton et al, 2016 , Shajari et al, 2020 ). Interestingly, values greater than 0.8 indicate low stability for a drug delivery/nano-delivery/colloidal system.…”

Section: Resultsmentioning

confidence: 99%

Surface innovation to enhance anti-droplet and hydrophobic behavior of breathable compressed-polyurethane masks

Ray

Park

Nam

et al. 2020

Environmental Technology & Innovation

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With the emergence of the coronavirus disease (COVID-19), it is essential that face masks demonstrating significant anti-droplet and hydrophobic characteristics are developed and distributed. In this study, a commercial compressed-polyurethane (C-PU) mask was modified by applying a hydrophobic and anti-droplet coating using a silica sol, which was formed by the hydrolysis of tetraethoxysilane (TEOS) under alkaline conditions and hydrolyzed hexadecyltrimethoxysilane (HDTMS) to achieve hydrophobization. The modified mask (C-PU/Si/HDTMS) demonstrated good water repellency resulting in high water contact angle (132°) and low sliding angle (17°). Unmodified and modified masks were characterized using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS). A drainage test confirmed the strong interaction between the mask surface and coating. Moreover, the coating had negligible effect on the average pore size of the C-PU mask, which retained its high breathability after modification. The application of this coating is a facile approach to impart anti-droplet, hydrophobic, and self-cleaning characteristics to C-PU masks.

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Section: Resultsmentioning

confidence: 99%

Surface innovation to enhance anti-droplet and hydrophobic behavior of breathable compressed-polyurethane masks

Ray

Park

Nam

et al. 2020

Environmental Technology & Innovation

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“…In vitro antibacterial activity was determined using curcumin-loaded solid lipid nanoparticles and as well as with free curcumin. The results of the study indicated that nanocurcumin reduced the total microbe count as well as the number of wild strains of bacteria [90]. This shows that curcumin-loaded solid lipid nanoparticles can be used as an eco-friendly tool for the eradication of harmful pathogens from wastewater.…”

Section: Solid Lipid Nanocarriersmentioning

confidence: 86%

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

et al. 2022

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Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of bacteria, even those resistant to antibiotics. Curcumin has been shown to be effective against the microorganisms that are responsible for surgical infections and implant-related bone infections, primarily Staphylococcus aureus and Escherichia coli. The efficacy of curcumin against Helicobacter pylori and Mycobacterium tuberculosis, alone or in combination with other classic antibiotics, is one of its most promising antibacterial effects. Curcumin is known to have antifungal action against numerous fungi that are responsible for a variety of infections, including dermatophytosis. Candidemia and candidiasis caused by Candida species have also been reported to be treated using curcumin. Life-threatening diseases and infections caused by viruses can be counteracted by curcumin, recognizing its antiviral potential. In combination therapy with other phytochemicals, curcumin shows synergistic effects, and this approach appears to be suitable for the eradication of antibiotic-resistant microbes and promising for achieving co-loaded antimicrobial pro-regenerative coatings for orthopedic implant biomaterials. Poor water solubility, low bioavailability, and rapid degradation are the main disadvantages of curcumin. The use of nanotechnologies for the delivery of curcumin could increase the prospects for its clinical application, mainly in orthopedics and other surgical scenarios. Curcumin-loaded nanoparticles revealed antimicrobial properties against S. aureus in periprosthetic joint infections.

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“…With the aim of implementing a novel strategy to remove different bacterial pathogens from hospital wastewater an eco-friendly CUR-loaded nano-structured lipid carriers was prepared using hot high-speed homogenization [ 158 ]. The in vitro antibacterial activity of pure CUR and the nano-carriers evaluated using a turbidity assay in Luria–Bertani media and standard and wild-type bacteria strains.…”

Section: Encapsulation and Evaluation Of Therapeutic Benefits Of Curmentioning

confidence: 99%

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

et al. 2021

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There is a dearth of natural remedies available for the treatment of an increasing number of diseases facing mankind. Natural products may provide an opportunity to produce formulations and therapeutic solutions to address this shortage. Curcumin (CUR), diferuloylmethane; I,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione is the major pigment in turmeric powder which has been reported to exhibit a number of health benefits including, antibacterial, antiviral, anti-cancer, anti-inflammatory and anti-oxidant properties. In this review, the authors attempt to highlight the biological and pharmacological properties of CUR in addition to emphasizing aspects relating to the biosynthesis, encapsulation and therapeutic effects of the compound. The information contained in this review was generated by considering published information in which evidence of enhanced biological and pharmacological properties of nano-encapsulated CUR was reported. CUR has contributed to a significant improvement in melanoma, breast, lung, gastro-intestinal, and genito-urinary cancer therapy. We highlight the impact of nano-encapsulated CUR for efficient inhibition of cell proliferation, even at low concentrations compared to the free CUR when considering anti-proliferation. Furthermore nano-encapsulated CUR exhibited bioactive properties, exerted cytotoxic and anti-oxidant effects by acting on endogenous and cholinergic anti-oxidant systems. CUR was reported to block Hepatitis C virus (HCV) entry into hepatic cells, inhibit MRSA proliferation, enhance wound healing and reduce bacterial load. Nano-encapsulated CUR has also shown bioactive properties when acting on antioxidant systems (endogenous and cholinergic). Future research is necessary and must focus on investigation of encapsulated CUR nano-particles in different models of human pathology.

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Eco-friendly curcumin-loaded nanostructured lipid carrier as an efficient antibacterial for hospital wastewater treatment

Cited by 25 publications

References 32 publications

Surface innovation to enhance anti-droplet and hydrophobic behavior of breathable compressed-polyurethane masks

Surface innovation to enhance anti-droplet and hydrophobic behavior of breathable compressed-polyurethane masks

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

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