Eco-friendly Based UV Spectrophotometric Method and Analytical Quality by Design Aided Stability Indicating RP-HPLC Technique for the Estimation of Molnupiravir

Perumal, Durgadevi; Krishnan, Manikandan; Lakshmi, K. S.

doi:10.1080/22297928.2023.2224806

Analytical Chemistry Letters

2023

DOI: 10.1080/22297928.2023.2224806

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Eco-friendly Based UV Spectrophotometric Method and Analytical Quality by Design Aided Stability Indicating RP-HPLC Technique for the Estimation of Molnupiravir

Durgadevi Perumal

Manikandan Krishnan

K. S. Lakshmi

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2024

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Cited by 5 publications

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“…Several chromatographic and spectral methods were reported for MLN detection either individually or with other drugs in various matrices including; HPLC, [11][12][13][14][15] TLC, 16,17 and spectrophotometric. [18][19][20] These techniques had several drawbacks, including a time-consuming, high solvent consumption rate, many extraction steps, and pricey equipment. Electrochemical methods are some of the most common instrumental techniques applied in different fields such as environmental analysis, 21 detection of food contaminations, 22 human medical field, 23,24 animal medical field, 25 and botanical medical fied.…”

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confidence: 99%

Innovative Molecularly Imprinted Electrochemical Sensor for Selective Nanomolar Detection of the Anti-COVID-19 Medication Molnupiravir

Sayed,

Elmasry,

Taha

et al. 2024

J. Electrochem. Soc.

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For the first time, a green ecofriendly approach is applied, to develop a molecularly imprinted polymer (MIP) electrochemical for the assay of the oral anti-viral molnupiravir (MLN) as confirmed on referring to: analytical eco-scale, green analytical procedure index (GAPI), Raynie and Driver, analytical greenness metric (AGREE), and national environmental index (NEMI). MIP was electropolymerized on a glassy carbon electrode (GCE) modified with gold nanoparticles (MIP/AuNPs/GCE) to create a selective and efficient electrochemical nanosensor. The detection limit was set at 0.00098 ng/mL (3×10-12M) and the linearity range of MLN was between 0.033 ng/mL and 164 ng/mL (1×10-10–5×10-7 M). The MIP sensor was employed for MLN determination in its pharmaceutical product , spiked human plasma, and urine samples with mean recovery % (99.82% ± 0.53), (99.88% ± 0.62), and (97.90% ± 0.70), respectively. The investigated sensor provided good reproducibility, repeatability, and durability. Acceptable selectivity regarding MLN when mixed with structurally comparable compounds was proved with mean recovery % ± mean RSD (97.10% ± 0.03). Additionally, when molnupiravir was exposed to oxidative, hydrolytic, and thermal stress conditions, good results in stability-indicating studies served as an indicator of sensor selectivity.The developed electrode is coupled with a portable potentiostat, making it a promising point-of-care diagnostic.

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mentioning

confidence: 99%

Innovative Molecularly Imprinted Electrochemical Sensor for Selective Nanomolar Detection of the Anti-COVID-19 Medication Molnupiravir

Sayed,

Elmasry,

Taha

et al. 2024

J. Electrochem. Soc.

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Ultra‐high‐performance liquid chromatography method development for the quantification of Molnupiravir and its process‐related impurities using Box‐Behnken experimental design

Nuli,

Bhikshapathi,

Garige

et al. 2024

Separation Science Plus

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Molnupiravir, a promising antiviral agent, has gained significant attention for its potential in treating viral infections, particularly in the context of the coronavirus disease 2019 pandemic. This study aimed to develop and validate an ultra‐high‐performance liquid chromatography (UHPLC) method for the quantification of Molnupiravir and its associated impurities (Imp‐I, Imp‐II, Imp‐III, and Imp‐IV). The method involved a systematic investigation of critical method parameters and their optimization using Quality by Design principles. The percentage of organic modifiers, column temperature, and flow rate were systematically optimized using the Box‐Behnken design. The developed method was assessed for specificity, system suitability, accuracy, precision, linearity, and detection limits. The results demonstrate strong specificity, with the analysis remaining accurate even in the presence of impurities. The developed method exhibits excellent precision, with repeatability and intermediate precision showing relative standard deviation values ranging from 0.78% to 1.14% for impurities and 0.82% to 1.91% for Molnupiravir. Furthermore, the method displays exceptional linearity, covering a wide range of concentrations. The linear regression analysis yields high coefficients of determination (r2, 9993–0.9997), confirming the linearity. The developed UHPLC method is well‐suited for the accurate and reliable analysis of Molnupiravir and its impurities, making it a valuable tool for quality control and pharmaceutical research applications.

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A step toward Molnupiravir, COVID-19 Antiviral, detection using Cauliflower-Like cobalt Sulfide-Decorated carbon nanotube modified glassy carbon electrodes

Khezerloo,

Hekmat,

shahrokhian

et al. 2024

Microchemical Journal

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Eco-friendly Based UV Spectrophotometric Method and Analytical Quality by Design Aided Stability Indicating RP-HPLC Technique for the Estimation of Molnupiravir

Cited by 5 publications

References 18 publications

Innovative Molecularly Imprinted Electrochemical Sensor for Selective Nanomolar Detection of the Anti-COVID-19 Medication Molnupiravir

Innovative Molecularly Imprinted Electrochemical Sensor for Selective Nanomolar Detection of the Anti-COVID-19 Medication Molnupiravir

Ultra‐high‐performance liquid chromatography method development for the quantification of Molnupiravir and its process‐related impurities using Box‐Behnken experimental design

A step toward Molnupiravir, COVID-19 Antiviral, detection using Cauliflower-Like cobalt Sulfide-Decorated carbon nanotube modified glassy carbon electrodes

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