Eco-friendly and regioselective synthesis of 3-(isoxazol-5)-yl) indoles from β-ethylthio-β-indolyl-α, β-unsaturated ketones in water

Green Tandem [5C + 1C] Cycloaromatization of α-Alkenoyl Ketene Dithioacetals and Nitroethane in Water: Eco-Friendly Synthesis of Ortho-Acylphenols

“…In view of the importance of ortho -acylphenols and our ongoing interests in aqueous organic synthesis and the synthetic application of α-oxo ketene dithioacetals, we recently researched in detail tandem [5C + 1C] annulations of α-alkenoyl ketene dithioacetals and nitroethane in water to prepare ortho -acylphenols. It was found that there were tandem Michael addition/cyclization/aromatization reactions between α-alkenoyl ketene dithioacetals and nitroethane in the presence of 2.0 equivalents of DBU in boiling water, affording ortho -acylphenols in excellent yields (Scheme ).…”