Eco-Epidemiological and Immunological Features of Localized Cutaneous Leishmaniasis in Southeastern Mexico: Thirty Years of Study

Andrade-Narvaez, Fernando J.; Wynsberghe, Nicole R. Van; Sosa-Bibiano, Erika Ivett; Loría-Cervera, Elsy Nalleli

doi:10.5772/66130

Cited by 7 publications

(8 citation statements)

References 30 publications

(37 reference statements)

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“…In 1912, Seidelin described LCL as “chiclero's ulcer” because the main affected population were collectors of chewing gum (chicle) working in the sylvatic region of the Yucatan Peninsula (Seidelin, 1912). Since then, mainly the states of Campeche and Quintana Roo have been considered endemic areas of the disease (Andrade-Narvaez et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Preliminary epidemiological findings of Leishmania infection in the municipality of Tinum, Yucatan State, Mexico

Loría-Cervera

Sosa-Bibiano

Wynsberghe

et al. 2019

Parasite Epidemiology and Control

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Localized cutaneous leishmaniasis (LCL) is endemic in Mexico, mainly in the states of Campeche and Quintana Roo, hyperendemic areas of Leishmania (Leishmania) mexicana transmission. In this report, epidemiological features of Leishmania infections in the municipality of Tinum, Yucatan State, Mexico are presented. Nine cases of LCL were diagnosed in 2015. Patients were men between 30 and 74 years of age, without a history of living or traveling to endemic areas (Quintana Roo or Campeche). Due to asymptomatic infection is the most common outcome after Leishmania inoculation, between November 2017 to June 2018, 47 men working in the forest were tested by Montenegro skin test (MST). Thirteen of them (27.6%) were identified MST positive, in absence of either lesion or typical scar, and evidence of exposure to vector. Findings in Tinum, Yucatan, supported the presence of specific environmental conditions that seem to favor Leishmania transmission in this region. Thus, active surveillance for the detection of new cases in the municipality of Tinum as well as the eco-epidemiological characterization to identify all the transmission components (parasite, vector, and reservoir species) are urgently needed.

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Section: Discussionmentioning

confidence: 99%

Preliminary epidemiological findings of Leishmania infection in the municipality of Tinum, Yucatan State, Mexico

Loría-Cervera

Sosa-Bibiano

Wynsberghe

et al. 2019

Parasite Epidemiology and Control

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“…La LCL es una enfermedad de naturaleza zoonótica, cuyo agente etiológico alterna entre mamíferos silvestres y hembras hematófagas de la subfamilia Phlebotominae (Diptera: Psychodidae) (1). En México, la mayor incidencia y prevalencia de LCL ocurre en la Península de Yucatán (2), en donde el 99% de los casos son causados por Leishmania mexicana (3).…”

Section: Introductionunclassified

“…En la Península de Yucatán, los casos humanos son de naturaleza ocupacional, ya que ocurren principalmente en hombres de entre 14 y 45 años que se internan en la selva para realizar diversas actividades agrícolas (3). Sin embargo, la población afectada podría incluir otros sectores (ej.…”

Section: Introductionunclassified

Registro de flebotomíneos antropofílicos en el peridomicilio de un caso de leishmaniosis cutánea localizada en Yucatán, México

Oca-Aguilar¹,

Sosa-Bibiano²,

López-Ávila³

et al. 2023

revbiomed

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Introducción. Desde el 2015, se han reportado casos emergentes de leishmaniosis cutánea localizada (LCL) en Tinum, Yucatán. Sin embargo, no existen registros de flebotomíneos en el peridomicilio. Objetivo. Reportar la presencia de flebotomíneos antropofílicos en el peridomicilio de un caso de LCL en el municipio de Tinum, Yucatán, México. Materiales y Métodos. Se realizó la historia clínica de la paciente. El diagnóstico y la identificación de especie de Leishmania se determinaron mediante PCR-RFLP. Se colocaron dos trampas CDC en el peridomicilio. Resultados. La paciente era una mujer de 65 años con una úlcera en la pierna izquierda, que no realiza actividades selváticas de riesgo. Se identificó a Leishmania mexicana como agente causal. Se colectó a Bichromomyia olmeca olmeca, Lutzomyia cruciata y Lutzomyia longipalpis en el peridomicilio. Conclusión. Se presenta el primer registro de flebotomíneos en el ambiente peridoméstico en Yucatán, lo que sugiere el riesgo de transmisión peridoméstica.

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“…Localized cutaneous leishmaniasis (LCL) is endemic in Mexico, mainly in the states of Veracruz, Tabasco, Oaxaca, Chiapas, Campeche, and Quintana Roo [ 8 ]. The disease could be asymptomatic or manifest as an ulcer with raised borders located mainly in the ear (39.8%) [ 8 – 10 ]. Most studies to characterize the eco-epidemiological features of LCL have been conducted in the state of Campeche [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The disease could be asymptomatic or manifest as an ulcer with raised borders located mainly in the ear (39.8%) [ 8 – 10 ]. Most studies to characterize the eco-epidemiological features of LCL have been conducted in the state of Campeche [ 10 ]. According to those studies, the main causal agent is Leishmania ( Leishmania ) mexicana and the only proven vector is Lutzomyia olmeca olmeca .…”

Section: Introductionmentioning

confidence: 99%

Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico

Sosa-Bibiano

-Martínez

López-Ávila

et al. 2022

Journal of Tropical Medicine

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In 2015, emergent cases of localized cutaneous leishmaniasis (LCL) were reported in Tinum, Yucatan, Mexico. As part of an eco-epidemiological study to characterize the elements that trigger Leishmania infection in that area, we conducted a field study to investigate the occurrence of Leishmania infection in wild rodents. From November 2019 to February 2020, rodents were caught from three sites located in the municipality of Tinum, Yucatan. For each specimen, clinical signs suggestive of Leishmania infection were recorded. Samples from the tail, liver, and spleen were taken for the identification of Leishmania DNA by PCR. Twenty rodents belonging to two species were caught including Heteromys gaumeri (55%, 11/20) and Ototylomys phyllotis (45%, 9/20). Fifty-five percent of the animals presented white spots on the tail, 15% had splenomegaly, and 5% had hepatomegaly. Fifty-five percent (11/20) of the animals were found infected by Leishmania. Heteromys gaumeri was caught in all trapping sites and was the most infected species (63.6%, 7/11). The percentage of infection for O. phyllotis was 44.4% (4/9). Leishmania (Leishmania) mexicana was identified as the infecting species in two H. gaumeri. This study provides, for the first time, evidence of Leishmania infection in wild rodents from the Yucatan state. Heteromys gaumeri and O. phyllotis may be involved in the transmission cycle of L. mexicana in this emergent focus; however, further longitudinal studies are needed to confirm their role as primary reservoirs.

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Eco-Epidemiological and Immunological Features of Localized Cutaneous Leishmaniasis in Southeastern Mexico: Thirty Years of Study

Cited by 7 publications

References 30 publications

Preliminary epidemiological findings of Leishmania infection in the municipality of Tinum, Yucatan State, Mexico

Preliminary epidemiological findings of Leishmania infection in the municipality of Tinum, Yucatan State, Mexico

Registro de flebotomíneos antropofílicos en el peridomicilio de un caso de leishmaniosis cutánea localizada en Yucatán, México

Leishmania (Leishmania) mexicana Infection in Wild Rodents from an Emergent Focus of Cutaneous Leishmaniasis in Yucatan, Mexico

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