Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in <i>Daphnia magna</i>

Fadare, Oluniyi O.; Wan, Bin; Liu, Keyang; Yang, Yu; Zhao, Lingjuan; Guo, Liang-Hong

doi:10.1021/acs.est.0c00615

Cited by 121 publications

(100 citation statements)

References 70 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cellular uptake and subsequent toxicity of nanoplastic particles is dependent on the unique protein and chemical corona that forms on the surface during contact with biological fluids (e.g. pulmonary surfactant, interstitial fluid, plasma) and environmental chemicals; in the case of plastics these chemicals may be adsorbed and serve and a vehicle for chemical transport [46]. Chemical additives adsorbed to the surface or added to plastics during the polymerization process can leach or be transferred from polystyrene products with normal use.…”

Section: Discussionmentioning

confidence: 99%

Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

et al. 2020

View full text Add to dashboard Cite

Background Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic and nanoplastic particulates are formed from bulk fragmentation and disintegration of plastic pollution. Plastic particulates have recently been detected in indoor air and remote atmospheric fallout. Due to their small size, microplastic and nanoplastic particulate in the atmosphere can be inhaled and may pose a risk for human health, specifically in susceptible populations. When inhaled, nanosized particles have been shown to translocate across pulmonary cell barriers to secondary organs, including the placenta. However, the potential for maternal-to-fetal translocation of nanosized-plastic particles and the impact of nanoplastic deposition or accumulation on fetal health remain unknown. In this study we investigated whether nanopolystyrene particles can cross the placental barrier and deposit in fetal tissues after maternal pulmonary exposure. Results Pregnant Sprague Dawley rats were exposed to 20 nm rhodamine-labeled nanopolystyrene beads (2.64 × 1014 particles) via intratracheal instillation on gestational day (GD) 19. Twenty-four hours later on GD 20, maternal and fetal tissues were evaluated using fluorescent optical imaging. Fetal tissues were fixed for particle visualization with hyperspectral microscopy. Using isolated placental perfusion, a known concentration of nanopolystyrene was injected into the uterine artery. Maternal and fetal effluents were collected for 180 min and assessed for polystyrene particle concentration. Twenty-four hours after maternal exposure, fetal and placental weights were significantly lower (7 and 8%, respectively) compared with controls. Nanopolystyrene particles were detected in the maternal lung, heart, and spleen. Polystyrene nanoparticles were also observed in the placenta, fetal liver, lungs, heart, kidney, and brain suggesting maternal lung-to-fetal tissue nanoparticle translocation in late stage pregnancy. Conclusion These studies confirm that maternal pulmonary exposure to nanopolystyrene results in the translocation of plastic particles to placental and fetal tissues and renders the fetoplacental unit vulnerable to adverse effects. These data are vital to the understanding of plastic particulate toxicology and the developmental origins of health and disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Interestingly, we here observed reduced toxicity of the NPs in a long-term study when conditioned with eco-corona biomolecules. However, the formation of NP coronas has been shown to inflict both positive and negative effects on toxicity and it is likely that they are both corona and material specific 6 , 18 , 31 . No tendency for acute (24–48 h) toxic effects on Daphnia was observed in our study, suggesting that the effect of the initial conditioning of the WC–Co and Co NPs with the eco-corona biomolecules had lasting effects despite the continuous build-up of secreted degradation products throughout the experiment in all treatments.…”

Section: Resultsmentioning

confidence: 99%

Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna

Ekvall

Hedberg

Wallinder

et al. 2021

Sci Rep

View full text Add to dashboard Cite

As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP’s) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming surface coronas, is limited. However, we show here that the toxic effect of NPs of tungsten carbide cobalt (WC–Co) and cobalt (Co) on the crustacean Daphnia magna is postponed in the presence of natural biological degradation products (eco-corona biomolecules). For Daphnia exposed to WC–Co NPs the survival time increased with 20–25% and for Co NPs with 30–47% after mixing the particles with a solution of eco-corona biomolecules before exposure. This suggests that an eco-corona, composed of biomolecules always present in natural ecosystems, reduces the toxic potency of both studied NPs. Further, the eco-coronas did not affect the particle uptake, suggesting that the reduction in toxicity was related to the particle-organism interaction after eco-corona formation. In a broader context, this implies that although the increasing use and production of NPs may constitute a novel, global environmental threat, the acute toxicity and long-term effects of some NPs will, at least under certain conditions, be reduced as they enter natural ecosystems.

show abstract

“…Cellular uptake and subsequent toxicity of nanoplastic particles is dependent on the unique protein and chemical corona that forms on the surface during contact with biological uids (e.g. pulmonary surfactant, interstitial uid, plasma) and environmental chemicals; in the case of plastics these chemicals may be adsorbed and serve and a vehicle for chemical transport [46]. Chemical additives adsorbed to the surface or added to plastics during the polymerization process can leach or be transferred from polystyrene products with normal use.…”

Section: Discussionmentioning

confidence: 99%

Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

Fournier

D’Errico

Adler

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic and nanoplastic particulates are formed from bulk fragmentation and disintegration of plastic pollution. Plastic particulates have recently been detected in indoor air and remote atmospheric fallout. Due to their small size, microplastic and nanoplastic particulate in the atmosphere can be inhaled and may pose a risk for human health, specifically in susceptible populations. When inhaled, nanosized particles have been shown to translocate across pulmonary cell barriers to secondary organs, including the placenta. However, the potential for maternal-to-fetal translocation of nanosized-plastic particles and the impact of nanoplastic deposition or accumulation on fetal health remain unknown. In this study we investigated whether nanopolystyrene particles can cross the placental barrier and deposit in fetal tissues after maternal pulmonary exposure.Results: Pregnant Sprague Dawley rats were exposed to 20 nm rhodamine-labeled nanopolystyrene beads (2.64 x 1014 particles) via intratracheal instillation on gestational day (GD) 19. Twenty-four hours later on GD 20, maternal and fetal tissues were evaluated using fluorescent optical imaging. Fetal tissues were fixed for particle visualization with hyperspectral microscopy. Using isolated placental perfusion, a known concentration of nanopolystyrene was injected into the uterine artery. Maternal and fetal effluents were collected for 180 minutes and assessed for polystyrene particle concentration. Twenty-four hours after maternal exposure, fetal and placental weights were significantly lower (7% and 8%, respectively) compared with controls. Nanopolystyrene particles were detected in the maternal lung, heart, and spleen. Polystyrene nanoparticles were also observed in the placenta, fetal liver, lungs, heart, kidney, and brain suggesting maternal lung-to-fetal tissue nanoparticle translocation in late stage pregnancy.Conclusion: These studies confirm that maternal pulmonary exposure to nanopolystyrene results in the translocation of plastic particles to placental and fetal tissues and renders the fetoplacental unit vulnerable to adverse effects. These data are vital to the understanding of plastic particulate toxicology and the developmental origins of health and disease.

show abstract

Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna

Cited by 121 publications

References 70 publications

Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

Adsorption of bio-organic eco-corona molecules reduces the toxic response to metallic nanoparticles in Daphnia magna

Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

Contact Info

Product

Resources

About