ECM1 and ANXA1 in urinary extracellular vesicles serve as biomarkers for breast cancer
Hai Huang,
Jingyu Wan,
Xudong Ao
et al.
Abstract:ObjectiveAlthough urinary extracellular vesicles (uEVs) have been extensively studied in various cancers, their involvement in breast cancer (BC) remains largely unexplored. The non-invasive nature of urine as a biofluid and its abundant protein content offer considerable potential for the early detection of breast cancer.MethodsThis study analyzed the proteomic profiles of uEVs from BC patients and healthy controls (HC). The dysregulation of ECM1 and ANXA1 in the uEVs was validated in a larger cohort of 128 B… Show more
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