Eclosion Hormone-Mediated Signal Transduction in the Silkworm Abdominal Ganglia: Involvement of a Cascade from Inositol(1,4,5)trisphosphate to Cyclic GMP

Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons

“…Biochemical results obtained using the abdominal CNS of Manduca suggest that EH stimulates cGMP via metabolites of arachidonic acid (Morton and Giunta, 1992). In contrast, experiments in the commercial silkworm, Bombyx mori, on saponin-treated ganglia support a pathway leading from inositol triphosphate production and through subsequent calcium activation of nitric oxide synthase and, hence, to the soluble guanylate cyclase (Shibanaka et al, 1993(Shibanaka et al, , 1994. The immunocytochemical results reported here reveal an unexpected complexity in the involvement of cGMP with ecdysis.…”

Platelet-derived Growth Factor β-Receptor, Transforming Growth Factor β Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

“…TGF␤ also induces activation of non-Smad pathways, including the ERK, JNK, and p38 MAPK pathways, as well as PI3K/Akt (5). Moreover, T␤RI undergoes ligand-dependent intramembrane proteolysis, which releases its intracellular domain that, after translocation to the nucleus, drives an invasiveness program (6).…”

Neuropeptide-stimulated cyclic guanosine monophosphate immunoreactivity in the neurosecretory terminals of a neurohemal organ

“…Both of these properties suggest that EH ac-tivates a cGC (Trembley et al, 1988). Although in Bombyx mori, the EH-stimulated increase in cGMP is believed to be mediated by NO (Shibanaka et al, 1994), a variety of experiments have shown that in Munducu the EH-stimulated increase in cGMP is NO independent and requires lipid metabolism (Morton and Giunta, 1992;Morton and Simpson, 1995). The present study shows that the EH-stimulated increase in cGMP in the transverse nerve can also be blocked by inhibitors of lipid metabolism.…”