ECIEN-2020 study: the effect of COVID-19 on admissions for non-COVID-19 diseases

Ramos-Lacuey, Beatriz; Aguirre, Mercedes; Gallego, Clara Calderón; Munain, Andrea Ilundain López de; Esarte, E. Gembero; Moreno‐Galarraga, Laura

doi:10.1007/s12519-020-00406-9

Cited by 14 publications

(14 citation statements)

References 26 publications

(32 reference statements)

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“…This was sharply in contrast with a steady increase in referrals for growth issues that we reported from 2014 to 2018 in a previous study [ 1 ], even though the criteria – according to the Italian Medicines Agency (AIFA) – to perform stimulation tests were the same (i.e., height ≤ − 3 SD; or height ≤ − 2 SD + growth velocity per year ≤ − 1 DS for age and sex evaluated for at least 6 months or a reduction of height of 0.5 SD per year in children > 2 years of age; or height ≤ − 1.5 SD compared to target height and growth velocity per year ≤ − 2 SD or ≤ − 1.5 SD for two consecutive years; or growth velocity per year ≤ − 2 SD or ≤ − 1.5 SD after two consecutive years, even without short stature and after exclusion of other causes of failure to thrive; or malformations/lesions of hypothalamus/pituitary demonstrated at brain MRI) [ 13 ]. Although this is the first study reporting a decrease of referrals for suspected GHD during 2020 lockdowns, our results align with previous reports addressing a delay of hospital care admissions and a reduction of 30–40% in visits during the COVID-19 pandemic [ 9 , 10 ]. A possible explanation for the decrease in tests for suspected GHD is that well-child visits were canceled during the pandemics, removing a chance for family pediatricians to detect short stature and delayed growth.…”

Section: Discussionsupporting

confidence: 91%

Reduction in pediatric growth hormone deficiency and increase in central precocious puberty diagnoses during COVID 19 pandemics

et al. 2022

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Background While several studies have been published so far on the effect of COVID-19 pandemic on health care for non-COVID-19 diseases, to date no study evaluated the impact of the COVID-19 pandemic on the entire field of pediatric endocrinology. This study aimed to evaluate differences in pediatric endocrine stimulation tests after the advent of COVID-19 pandemics. Methods Retrospective study with data collection for pediatric endocrine stimulation tests performed in 2019 and 2020 in a tertiary center. Results Overall, 251 tests were performed on 190 patients in 2020, compared to 278 tests on 206 patients in 2019 (− 10% tests; − 8% children evaluated). A significant reduction was found in tests to diagnose growth hormone deficiency (GHD) (− 35%), while LHRH tests increased (+ 22%). A reduction of 30% in GHD diagnosis was observed. Central precocious puberty (CPP) diagnosis increased by 38% compared to 2019, mainly in females. Conclusion This study found a significant reduction of tests investigating GHD during COVID-19 pandemics. It also showed a clinically meaningful increase in cases of CPP in girls. These results suggest the need for families and pediatricians to monitor children’s growth during isolation and enlighten new perspectives towards conditions associated with lockdown restrictions as increased screen time, social isolation, and children’s anxiety as possible triggers of CPP.

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Section: Discussionsupporting

confidence: 91%

Reduction in pediatric growth hormone deficiency and increase in central precocious puberty diagnoses during COVID 19 pandemics

et al. 2022

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“…Among symptomatic patients, fever (>38 • C) was the most common symptom (37/41), with a mean duration of 3.11 days (SD 3.01). An epidemiological description of all pediatric patients with laboratory confirmed COVID-19 in Navarre, and a more detailed description of the CHN hospitalized patients have been performed [6,7,33]. No mortality, severe pulmonary complications or pulmonary emboli were detected in our study.…”

Section: Resultsmentioning

confidence: 72%

Chest radiograph in hospitalized children with COVID-19. A review of findings and indications

Munain

Veintemilla

Aguirre

et al. 2021

European Journal of Radiology Open

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COVID-19 clinical manifestations and radiological findings are milder and less specific in children.• The presence of fever, and fever duration are clinical findings associated with pathological chest imaging.• The most common pattern seen in pathological chest X ray were bilateral diffuse interstitial pattern followed by perihilar bronchial wall thickening.• Consensual specific age-adjusted protocols regarding chest imaging indications in pediatric COVID-19, as the one developed, are needed.• Imaging should not be used as a screening tool or a routine complementary test in pediatric hospitalized patients with COVID-19.

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“…A Spanish study reported a reduction in pediatric ED visits during the country’s first pandemic wave, although the percentage of hospitalizations following ED visits had doubled [ 17 ]. This finding is suggestive of a tendency for parents to refrain from presenting their children at the ED during the pandemic, in absence of severe health conditions [ 18 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Pediatric emergency department visits during the COVID-19 pandemic: a large retrospective population-based study

et al. 2021

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Background COVID-19 pandemic has stretched healthcare system capacities worldwide and deterred people from seeking medical support at Emergency Departments (ED). Nevertheless, population-based studies examining the consequences on children are lacking. Methods All ED visits from 2019 to 2020 in Veneto, Italy (4.9 million residents) were collected. Anonymized records of pediatric (≤14 years) ED visits included patient characteristics, arrival mode, triage code, clinical presentation, and discharge mode. Year-on-year variation of the main ED visit characteristics, and descriptive trends throughout the study period have been examined. Results Overall, 425,875 ED presentations were collected, 279,481 in 2019, and 146,394 in 2020 (− 48%), with a peak (− 79%) in March–April (first pandemic wave), and a second peak (below − 60%) in November–December (second pandemic wave). Burn or trauma, and fever were the two most common clinical presentations. Visits for nonurgent conditions underwent the strongest reduction during both pandemic waves, while urgent conditions reduced less sharply. ED arrival by ambulance was more common in 2020 (4.5%) than 2019 (3.5%), with a higher proportion of red triage codes (0.5%, and 0.4% respectively), and hospitalizations following ED discharge (9.1%, and 5.9% respectively). Conclusion Since the beginning of the COVID-19 pandemic, pediatric ED presentations underwent a steeper reduction than that observed for adults. Lockdown and fear of contagion in hospital-based services likely deterred parents from seeking medical support for their children. Given COVID-19 could become endemic, it is imperative that public health experts guarantee unhindered access to medical support for urgent, and less urgent health conditions, while minimizing infectious disease risks, to prevent children from suffering direct and indirect consequences of the pandemic.

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ECIEN-2020 study: the effect of COVID-19 on admissions for non-COVID-19 diseases

Cited by 14 publications

References 26 publications

Reduction in pediatric growth hormone deficiency and increase in central precocious puberty diagnoses during COVID 19 pandemics

Reduction in pediatric growth hormone deficiency and increase in central precocious puberty diagnoses during COVID 19 pandemics

Chest radiograph in hospitalized children with COVID-19. A review of findings and indications

Pediatric emergency department visits during the COVID-19 pandemic: a large retrospective population-based study

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