Echographic Study of Follicular Maturation and Ovulation During the Normal Menstrual Cycle

Rénaud, R; Macler, J; Dervain, I; Ehret, M.; C, Aron; Plas-Roser, S.; Spira, Alfred; Pollack, Henry

doi:10.1016/s0015-0282(16)44592-9

Cited by 98 publications

(19 citation statements)

References 4 publications

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“…Scans were then usually performed at least three times a week (Mondays, Wednesdays, and Fridays) until evidence of follicular collapse or an increase in echogenicity of the large follicle was observed. These latter two findings were considered presumed evidence of luteinization, as has been reported by other similar studies (1)(2)(3)(4)(5).…”

Section: Protocolsupporting

confidence: 57%

“…Several small studies, with up to 25 women, documented similar findings (1)(2)(3). Follicles in spontaneous cycles of midreproductive aged (MRA) women grow at a rate of between 2-6 mm daily, and ovulation has been reported to occur at a mean follicle diameter of 16 -27 mm.…”

Section: F Ollicle Growth Patterns In the Menstrual Cyclesmentioning

confidence: 74%

“…Follicles in spontaneous cycles of midreproductive aged (MRA) women grow at a rate of between 2-6 mm daily, and ovulation has been reported to occur at a mean follicle diameter of 16 -27 mm. The latter estimates were from a study that used transabdominal scanning, which may have resulted in larger estimates of follicle size (2). Nonetheless, follicle dynamics have been noted to be consistent in populations of normally cycling women.…”

Section: F Ollicle Growth Patterns In the Menstrual Cyclesmentioning

confidence: 99%

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Impaired Folliculogenesis and Ovulation in Older Reproductive Aged Women

Santoro

Isaac

Neal‐Perry

et al. 2003

The Journal of Clinical Endocrinology & Metabolism

110

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The objective of this study was to test the hypothesis that older reproductive aged women ovulate at a smaller follicle diameter and are more likely to produce multiple follicles during their menstrual cycle compared with midreproductive aged women. We performed a comparative study of 16 midreproductive aged women (MRA; 22-34 yr old) and 34 older reproductive aged women (ORA; >45 yr old). Women underwent serial transvaginal ultrasounds to follow follicular growth over 1 menstrual cycle. A subset of women (nine MRA and 19 ORA) had daily blood sampling. Scans were initiated within 1 wk of menses and were performed at least 3 times/wk until evidence of follicular collapse was observed. If there was no evidence of follicle growth beyond 10 mm by 20 d, observations (ultrasounds and blood sampling) were ended. Follicle growth was organized backward from maximum presumed preovulatory diameter. Hormones were standardized to d 0, the day when progesterone levels exceeded 2 ng/ml. Group comparisons were performed using ANOVA with Mann-Whitney post hoc testing and Kruskal-Wallis testing for integrated hormones. The main outcome measures were peak follicle diameter, follicle growth patterns, and circulating LH, F OLLICLE GROWTH PATTERNS in the menstrual cycles of reproductive aged women have been characterized using ultrasonographic evaluation. Several small studies, with up to 25 women, documented similar findings (1-3). Follicles in spontaneous cycles of midreproductive aged (MRA) women grow at a rate of between 2-6 mm daily, and ovulation has been reported to occur at a mean follicle diameter of 16 -27 mm. The latter estimates were from a study that used transabdominal scanning, which may have resulted in larger estimates of follicle size (2). Nonetheless, follicle dynamics have been noted to be consistent in populations of normally cycling women. Some recent studies have described the ovarian morphology and patterns of follicle growth associated with reproductive aging. Ovarian volume has been reported to decrease with age in a population of 13,963 women undergoing ovarian cancer screening (4). The inclusion of women in the age group between 30 -50 yr who were already naturally menopausal may have contributed disproportionately to these results, however, and the menopausal status of the younger women in this study is not provided. The number of antral follicles (i.e. Ͼ2 mm) in the ovaries has been reported to be significantly decreased in women over an age range of 22-42 yr old (5). These differences in follicle counts were independent of the stage of the menstrual cycle. Another study of 162 women that was confined to the early follicular phase alone (6) reported a mean yearly decline of antral follicle counts of about 5%, which increased to almost 12% after the age of 37 yr. Taken together, these data suggest that follicles in various stages of growth constitute the bulk of ovarian volume and that declining numbers of observable follicles occur concomitant with reproductive aging.Others have observed the patterns of f...

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Section: Protocolsupporting

confidence: 57%

Section: F Ollicle Growth Patterns In the Menstrual Cyclesmentioning

confidence: 74%

Section: F Ollicle Growth Patterns In the Menstrual Cyclesmentioning

confidence: 99%

See 1 more Smart Citation

Impaired Folliculogenesis and Ovulation in Older Reproductive Aged Women

Santoro

Isaac

Neal‐Perry

et al. 2003

The Journal of Clinical Endocrinology & Metabolism

110

View full text Add to dashboard Cite

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“…Follicular size and recent ovulation can be detected by ultrasonography with great accuracy (Renaud et al, 1980;Bryce et al, 1982). This method is not infallible in detecting ovulation since it shows follicular rupture and not egg release (ElkindHirsch et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

“…This method is not infallible in detecting ovulation since it shows follicular rupture and not egg release (ElkindHirsch et al, 1986). Determining follicular size by ultrasound in order to predict ovulation is highly inaccurate since the period until ovulation varies greatly among women with equal follicular size (Renaud et al, 1980;Kerin et al, 1981;Bryce et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

Comparison of a rapid, quantitative and automated assay for urinary luteinizing hormone (LH), with an LH detection test, for the prediction of ovulation

Bischof¹,

Bianchi²,

Campana³

1991

Human Reproduction

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The prediction of ovulation is necessary for oocyte aspiration in a spontaneous cycle and can be reliably achieved only by measuring luteinizing hormone (LH). Since radioimmunoassays of LH take too long for repeated measurements on the same day, we evaluated the possibility of adapting a rapid and fully automated assay of serum LH for use with urine samples. The study group comprised spontaneously ovulating women (38 cycles) who requested artificial insemination. Their serum oestradiol (E 2 ) levels, ultrasound profile (US) and thrice daily urinary LH levels were determined from day 10 of their menstrual cycle. These patients were followed until US signs of follicular rupture were recorded. In all patients, a well-defined LH peak was measured in the urine. This peak lasted 12-15 h and was followed in 35 cycles (no US available for 3) by follicular rupture 9-51 h later. The data were grouped according to the time of the LH peak on day 0. Patients experiencing an LH peak between 0300 h and 0700 h on day 0 had significantly lower levels of E 2 on day 0 compared to those with an LH peak between 2200 h and midnight. This is due to the fact that in the patients with an LH peak between 0300 h and 0700 h, E 2 levels were already decreasing (from day 1 to day 0), whereas in those with the LH peak between 2200 h and midnight E 2 levels were still increasing on the morning of day 0. We conclude that the 30-min IMX LH assay is a reliable, rapid and readily acceptable method for measuring urinary LH and for the prediction of ovulation.

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Noninvasive monitoring of follicle development, ovulation, and corpus luteum formation in the marmoset monkey (Callithrix jacchus) by ultrasonography

1996

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This is the first paper to describe ovarian changes associated with follicular growth, ovulation, and corpus luteum (CL) formation as monitored by ultrasonography in a multiovular primate, the marmoset monkey (Callithrix jacchus). Examinations were carried out transabdominally on unsedated females using a 10 MHz probe. Cycles were monitored by plasma progesterone and controlled by administration of prostaglandin F2α (PGF). The reliability of ultrasound was validated by comparing findings with direct observation of the ovaries at laparotomy. In eight females, 25 follicles were counted, of which 92% were depicted correctly by ultrasound. Of 14 CLs in five females, number and position were confirmed at laparotomy for 78%. Ultrasound examinations of ovaries throughout the follicular and luteal phase were performed in eight cycles and related to plasma profiles of luteinizing hormone (LH) and progesterone. One of these cycles was anovulatory. In the remaining seven cycles, 19 follicles were considered ovulatory follicles since they were seen on consecutive days and found again as CLs. Growth of individual follicles was monitored by measurements of follicle diameter from day 7 onward. Disappearance of follicles or changes in echogenicity were noted between days 9 and 11, preventing further measurements. Mean follicle size increased from 2.1 mm (range 1.6 mm–2.7 mm) on day 7 to 3.2 mm (range 2.7 mm–4.0 mm) on the day last seen. With one exception, the day follicles were last seen by ultrasound was consistent with the day of the preovulatory LH surge (day 9–11). The postovulatory rise in progesterone occurred 1–2 days later (day 11–13). These findings suggest that the day of ovulation as observed by ultrasound was characterized by either disappearance of follicles or increased follicular echogenicity. In conclusion, ultrasonography provides a reliable, noninvasive method for examinations of the ovarian cycle in the marmoset monkey. © 1996 Wiley‐Liss, Inc.

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Echographic Study of Follicular Maturation and Ovulation During the Normal Menstrual Cycle

Cited by 98 publications

References 4 publications

Impaired Folliculogenesis and Ovulation in Older Reproductive Aged Women

Impaired Folliculogenesis and Ovulation in Older Reproductive Aged Women

Comparison of a rapid, quantitative and automated assay for urinary luteinizing hormone (LH), with an LH detection test, for the prediction of ovulation

Noninvasive monitoring of follicle development, ovulation, and corpus luteum formation in the marmoset monkey (Callithrix jacchus) by ultrasonography

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