Echocontrast enhancers — how safe are they?

Preliminary experience with NC100100, a new ultrasound contrast agent for intravenous injection

“…Regardless of their chemical composition, there is a possibility that some microbubbles may become temporarily entrapped in the microcirculation, due to their size [25]. Microembolization should be suspected if tissue enhancement is static (as seen on B-mode imaging) and follows tissue motion, or if tissue enhancement lasts longer than opacification of the blood pool [26].…”

Intravascular contrast agent in the ultrasonography of ectopic pregnancy

“…The air bubbles increase the echo signal intensity of the vessels within the whole body. The safety of this agent has been verified by previous studies [6][7][8][9][10] .…”

Stability and natural frequency of nonspherical mode of an encapsulated microbubble in a viscous liquid

“…The bubble size is preferably large to increase efficacy in sonography, 60 but should be smaller than the blood capillary diameter for safety. 61 A lipid coated bubble is usually smaller than 5 µm in radius. 62 Most of polymer or albumin coated bubbles are smaller than 10 µm in radius.…”