Echocardiography image quality of global longitudinal strain in cardio-oncology: a prospective real-world investigation

Iida, Norimasa; Tajiri, Kazuko; Ishizu, Tomoko; Sasamura-Koshizuka, Rumi; Nakajima, Hideki; Kawamatsu, Naoto; Sato, Kimi; Yamamoto, Masayoshi; Bando, Hiroko; Sekine, Ikuo; Kawakami, Yasushi; Ieda, Masaki

doi:10.1007/s12574-022-00567-8

Cited by 6 publications

(9 citation statements)

References 15 publications

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“…Moreover, GLS is not representative of a specific disease and should be related to the ongoing clinical condition. 187 Large prospective studies are needed in order to provide better evidence and standardize cut-off values, avoiding statistical heterogeneity and publication bias. 188 F I G U R E 9 Evaluation after anthracycline chemotherapy (patient of Figure 7) and development of cardiotoxicity with significant reduction of GLS value.…”

Section: Cardio-oncologymentioning

confidence: 99%

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Myocardial strain of the left ventricle by speckle tracking echocardiography: From physics to clinical practice

Gherbesi,

Gianstefani,

Angeli

et al. 2024

Echocardiography

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Speckle tracking echocardiography (STE) is a reliable imaging technique of recognized clinical value in several settings. This method uses the motion of ultrasound backscatter speckles within echocardiographic images to derive myocardial velocities and deformation parameters, providing crucial insights on several cardiac pathological and physiological processes. Its feasibility, reproducibility, and accuracy have been widely demonstrated, being myocardial strain of the various chambers inserted in diagnostic algorithms and guidelines for various pathologies. The most important parameters are Global longitudinal strain (GLS), Left atrium (LA) reservoir strain, and Global Work Index (GWI): based on large studies the average of the lower limit of normality are −16%, 23%, and 1442 mmHg%, respectively. For GWI, it should be pointed out that myocardial work relies primarily on non‐invasive measurements of blood pressure and segmental strain, both of which exhibit high variability, and thus, this variability constitutes a significant limitation of this parameter. In this review, we describe the principal aspects of the theory behind the use of myocardial strain, from cardiac mechanics to image acquisition techniques, outlining its limitation, and its principal clinical applications: in particular, GLS have a role in determine subclinical myocardial dysfunction (in cardiomyopathies, cardiotoxicity, target organ damage in ambulatory patients with arterial hypertension) and LA strain in determine the risk of AF, specifically in ambulatory patients with arterial hypertension.

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Section: Cardio-oncologymentioning

confidence: 99%

“…However, oncological patients may have suboptimal windows, especially after radiotherapy and breast cancer surgery. Moreover, GLS is not representative of a specific disease and should be related to the ongoing clinical condition 187 …”

Section: Principal Clinical Applications Of Left Ventricular Strain A...mentioning

confidence: 99%

Myocardial strain of the left ventricle by speckle tracking echocardiography: From physics to clinical practice

Gherbesi,

Gianstefani,

Angeli

et al. 2024

Echocardiography

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“…1-5 Specifically, LV longitudinal myocardial dysfunction is considered the first marker of a preclinical form of HF with preserved ejection fraction (HFpEF), which is strongly associated with poor outcomes. [1][2][3][4][5] It is well known that nearly half of symptomatic HF patients compares and the association with cardiovascular events.…”

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confidence: 99%

“…Left ventricular (LV) longitudinal myocardial function is a sensitive marker of subtle abnormalities of LV myocardial performance, and useful for the prediction of outcomes for various type of cardiac diseases at each heart failure (HF) stage, and superior to conventional echocardiographic indices such as LV ejection fraction (LVEF). 1 – 5 Specifically, LV longitudinal myocardial dysfunction is considered the first marker of a preclinical form of HF with preserved ejection fraction (HFpEF), which is strongly associated with poor outcomes. 1 – 5 It is well known that nearly half of symptomatic HF patients have normal or preserved LVEF, a patient population that includes patients with current LVEF ≥50% but some previously documented reduced LVEF (rEF) <50%, as well as those with HFpEF.…”

mentioning

confidence: 99%

“… 1 – 5 Specifically, LV longitudinal myocardial dysfunction is considered the first marker of a preclinical form of HF with preserved ejection fraction (HFpEF), which is strongly associated with poor outcomes. 1 – 5 It is well known that nearly half of symptomatic HF patients have normal or preserved LVEF, a patient population that includes patients with current LVEF ≥50% but some previously documented reduced LVEF (rEF) <50%, as well as those with HFpEF. Furthermore, the number of patients with current LVEF ≥50% but previously detected HFrEF may become higher due to current guideline-directed medical therapy with 4 new types of medication.…”

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confidence: 99%

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Left Ventricular Longitudinal Myocardial Function of Heart Failure Patients With Transition From Reduced to Preserved Ejection Fraction and of Those With Preserved Ejection Fraction

Nagai,

Nishimori,

Kintsu

et al. 2024

Circ Rep

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Background: Left ventricular (LV) longitudinal myocardial function is associated with the outcomes of heart failure (HF) patients. HF with improved ejection fraction (EF), known as HFimpEF, which is defined as current LVEF >40% but any previously documented LVEF ≤40%, has favorable outcomes compared with HF with preserved EF (HFpEF). However, LV longitudinal myocardial function in patients with previously reduced LVEF (<50%) but improved LVEF to within the normal range (≥50%) (HFnorEF) and its association with cardiovascular events remain unclear. Methods and Results:We studied 70 patients with HFpEF and 65 with HFnorEF. LV longitudinal myocardial function was assessed as global longitudinal strain (GLS). The primary endpoint was defined as cardiovascular death or HF hospitalization during follow-up of 5.6±3.1 years. The GLS of HFpEF patients was significantly lower than that of HFnorEF patients (13.6±3.5% vs. 14.8±2.2%, P=0.02) even when the LVEF was similar. Multivariate Cox proportional hazards analysis showed that GLS was independently associated with cardiovascular events. Furthermore, of the entire study population, patients with GLS >15.0% had fewer cardiovascular events than those without (log-rank P=0.014) among all the patients. Conclusions: LV longitudinal myocardial dysfunction was more frequently observed in patients with HFpEF than in those with HFnorEF, even when LVEF was similar, and was independently associated with cardiovascular events for HF patients with current LVEF ≥50%.

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Ruane,

Prasad,

Atherton

2023

JACC: CardioOncology

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Echocardiography image quality of global longitudinal strain in cardio-oncology: a prospective real-world investigation

Cited by 6 publications

References 15 publications

Myocardial strain of the left ventricle by speckle tracking echocardiography: From physics to clinical practice

Myocardial strain of the left ventricle by speckle tracking echocardiography: From physics to clinical practice

Left Ventricular Longitudinal Myocardial Function of Heart Failure Patients With Transition From Reduced to Preserved Ejection Fraction and of Those With Preserved Ejection Fraction

Straining for More Evidence

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