Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type

Adin, Darcy B.; DeFrancesco, Teresa C.; Keene, Bruce W.; Tou, Sandra; Meurs, Kathryn M.; Atkins, Clarke E.; Aona, Brent; Kurtz, K. A.; Barron, Lara; Saker, Korinn E.

doi:10.1016/j.jvc.2018.11.002

Cited by 49 publications

(108 citation statements)

References 27 publications

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“…The Food and Drug Administration issued a warning and subsequently released data that identified dietary characteristics which were over-represented in consumer concern reports [31,32]. This data is supported by similar findings from researchers at multiple institutions and suggests that diets which are grain-free, contain legume or potato ingredients warrant study to further elucidate a possible role in the causation of DCM [28,29]. When evaluated, the FDA data also identifies an inverse relationship/correlation between the size of a company in terms of worldwide sales and the number of reported cases of DCM where smaller companies have the highest reported case numbers [32].…”

Section: Introductionmentioning

confidence: 86%

“…Nutritionally mediated DCM has been described across a variety of species including dogs and is most historically linked to taurine deficiency [17][18][19][20][21][22][23][24][25][26][27]. Recent peerreviewed research on DCM in breeds that were not previously known to have a genetic etiology has raised concern about the relationship between diets with certain characteristics and the development of nutritionally-mediated DCM [28][29][30]. The Food and Drug Administration issued a warning and subsequently released data that identified dietary characteristics which were over-represented in consumer concern reports [31,32].…”

Section: Introductionmentioning

confidence: 99%

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Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study

Ontiveros

Whelchel

et al. 2020

PLoS ONE

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Introduction A surge in Food and Drug Administration (FDA) consumer complaints identified concerns that legume-rich, grain-free diets were associated with nutritionally-mediated dilated cardiomyopathy (DCM). Golden retrievers represent the most reported breed affected by this condition and previous studies documented the disease is responsive to dietary change and taurine supplementation. Although dietary findings across cases are compelling, prospective studies with control groups are lacking. The role of diet in developing taurine deficiency and echocardiographic changes consistent with DCM in healthy dogs is unknown. Objectives We hypothesized that golden retrievers eating non-traditional diets are at a higher risk of having taurine deficiency and nutritionally-mediated DCM compared with those eating traditional commercial diets. We aimed to compare taurine concentrations and echocardiographic indices of systolic function between golden retrievers in each diet group and elucidate associations between diet and these variables. Additionally, we aimed to generate breed-specific reference intervals for whole blood and plasma taurine concentrations. Animals 86 golden retrievers.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study

Ontiveros

Whelchel

et al. 2020

PLoS ONE

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“…However, an increased likelihood of eating grain-free dog food does not necessarily correlate to increased risk of DCM, and a causative link between grain free diets and DCM has not yet been shown. While anecdotal reports of dogs improving after diet change have been reported as evidence that specific diets were the cause of DCM phenotype [7][8][9]16,38] close evaluation of the data reveals multiple variables at play, including initiation of taurine and carnitine supplementation, and medications to treat congestive heart failure and tachyarrhythmias [7][8][9]16,28,38,39]. All of these factors may play a role in the improvement of cardiac function in cases of DCM phenotype.…”

Section: One Veterinary Hospital Provided Age Distribution Date Over mentioning

confidence: 99%

Incidence of canine dilated cardiomyopathy, breed and age distributions, and grain-free diet sales in the United States from 2000-2019: A retrospective survey

Quest¹,

Clark²,

Garimella³

et al. 2020

Preprint

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BackgroundDilated cardiomyopathy (DCM) is considered a predominantly inherited disease in dogs. Recent reports suggest an increased incidence of DCM in atypical breeds eating grain-free and/or legume-rich diets. However, little data regarding incidence of DCM within the US is available; and no existing data quantifies DCM among breeds over time.HypothesisWe hypothesized that DCM incidence among breeds could be estimated by retrospective polling of veterinary cardiologists. Further, if a correlation existed between grain-free diets and DCM, an increase in DCM would be on trend with increased grain-free pet food sales.Materials and MethodsThirty-six U.S. cardiology specialty practices were asked for all initial canine and DCM cases evaluated from 2000-2019; fourteen cardiology practices participated. DCM signalment data was provided by three hospitals over 15 years; representing 68 breeds. Age distribution of DCM cases upon diagnosis were compared to other cardio cases and general hospital population from one hospital. All data were evaluated using linear regression models. Grain-free pet food sales data was evaluated from 2011-2019.ResultsFourteen hospitals participated and reported 67,243 unique canine patients. Nationally, data did not support a significant change in percent DCM over time (p=0.85). The overall average incidence rate of DCM during the study period was 3.83% (range 2.41-5.65%), while grain-free diet sales increased 500% from 2011-2019. No correlation between overall DCM incidence and grain free diet sales was discovered. A significant upward trend in mixed breeds diagnosed with DCM, with no significant trend in other breeds was appreciated. An upward trend in age at DCM diagnosis was identified, correlating with trends from overall hospital populations.ConclusionsThese data do not support overall increased DCM incidence, or a correlation with grain-free pet food sales. Additional data are necessary to understand whether regional factors contribute to increased DCM within smaller cohorts.

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“…(KAPLAN et al, 2018). Ainda, um recente estudo retrospectivo associou o fenótipo cardiomiopatia dilatada com certas dietas livres de grãos (ADIN et al, 2019).…”

Section: Degeneração Mixomatosa Valvarunclassified

Etiologias Da Disfunção Sistólica Em Cães

Costa¹,

Soares²

2020

SCI. ANIM. HEALTH

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Alterações cardíacas podem causar grande impacto hemodinâmico nos cães. Quando as funções do coração estão reduzidas, o organismo ativa mecanismos compensatórios que podem levar a insuficiência cardíaca. A disfunção sistólica é a perda da capacidade de contratilidade do coração, com consequente insuficiência miocárdica, que pode ser causada por sobrecarga de volume, sobrecarga de pressão e/ou disfunção miocárdica. Inúmeras patologias e etiologias podem cursar com disfunção sistólica, sendo as principais: cardiomiopatia dilatada, degeneração valvar em estágios avançados, hipotireoidismo, endocardite, miocardite, deficiência nutricional de taurina, taquiarritmias persistentes e toxicidade por doxorrubicina. A disfunção sistólica é detectada através do exame de ecocardiografia, através de parâmetros como a fração de ejeção ventricular, a fração de encurtamento e a distância E-septo. O tratamento da disfunção sistólica depende da causa e dos sinais clínicos envolvidos. Os principais fármacos utilizados no tratamento são os inotrópicos positivos, como digitálicos, simpaticomiméticos e inibidores das fosfodiesterases. O objetivo do presente trabalho foi revisar as principais causas da disfunção sistólica em cães, abordando a sua fisiopatologia, bem como o seu diagnóstico e a sua abordagem terapêutica.

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Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type

Cited by 49 publications

References 27 publications

Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study

Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study

Incidence of canine dilated cardiomyopathy, breed and age distributions, and grain-free diet sales in the United States from 2000-2019: A retrospective survey

Etiologias Da Disfunção Sistólica Em Cães

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