Echocardiographic measurements in infants of diabetic mothers and macrosomic infants of nondiabetic mothers

Demirören, Kaan; Çam, Lokman; Oran, Bülent; Koç, Hasan; Başpınar, Osman; Baysal, Tamer; Karaaslan, Sevim

doi:10.1515/jpm.2005.042

Cited by 22 publications

(20 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that neither cardiac dimensions nor cardiac function significantly differed between macrosomic ODM and those with an appropriate-for-date birth weight. As some studies have shown more cardiac alterations in macrosomic newborns of diabetic mothers when compared with macrosomic newborns of nondiabetic mothers [31, 32], we compared cardiac outcome of macrosomic ODM with that of macrosomic controls. No significant differences between those subgroups were found, indicating that neonatal macrosomia in ODM has no adverse effects on cardiac function at 7-8 years of age.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Function in 7-8-Year-Old Offspring of Women with Type 1 Diabetes

Rijpert

Breur

Evers

et al. 2011

Experimental Diabetes Research

View full text Add to dashboard Cite

Offspring of type 1 diabetic mothers (ODMs) are at risk of short-term and long-term complications, such as neonatal macrosomia (birth weight >90th percentile), hypertrophic cardiomyopathy, and cardiovascular morbidity in later life. However, no studies have been performed regarding cardiac outcome. In this study, we investigated cardiac dimensions and function in 30 ODMs at 7-8 years of age in relation to neonatal macrosomia and maternal glycemic control during pregnancy and compared these with those in a control group of 30 children of nondiabetic women. We found that cardiac dimensions and systolic and diastolic function parameters in ODMs were comparable with those in controls. Neonatal macrosomia and poorer maternal glycemic control during pregnancy were not related to worse cardiac outcome in ODM. We conclude that cardiac function at 7-8 years of age in offspring of women with type 1 diabetes is reassuring and comparable with that in controls.

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiac Function in 7-8-Year-Old Offspring of Women with Type 1 Diabetes

Rijpert

Breur

Evers

et al. 2011

Experimental Diabetes Research

View full text Add to dashboard Cite

show abstract

“…In human newborns, OHM were found to have echocardiographic evidence of diastolic dysfunction compared to normal neonates [16,17] . No study, to our knowledge, has followed these offspring into adulthood to determine if the diastolic dysfunction persists.…”

Section: Discussionmentioning

confidence: 98%

Programming of Adult Cardiovascular Disease following Exposure to Late-Gestation Hyperglycemia

Agoudemos¹,

Reinking²,

Koppenhafer³

et al. 2011

Neonatology

View full text Add to dashboard Cite

Background: In utero exposure to hyperglycemia is becoming increasingly prevalent as the number of women entering pregnancy with type II diabetes, or developing gestational diabetes, increases. Both animal studies and epidemiologic investigations have found cardiovascular abnormalities in adult offspring of hyperglycemic mothers (OHM). Objective: We hypothesized that adult OHM would have abnormal cardiac function in vivo and increased susceptibility to ischemia. Methods: Pregnant rats were made diabetic on day 12 of gestation. Serum glucose was monitored twice daily and insulin provided to maintain serum glucose at 200–400 mg/dl. Offspring were fostered to normal mothers after birth. Adult OHM were studied at 8–10 months of age with echocardiography to assess in vivo cardiac function and isolated hearts to determine the response to ischemia. Results: Echocardiography found significant diastolic dysfunction in male OHM compared to male controls. In isolated hearts, baseline cardiac function and left ventricular compliance was significantly diminished in male OHM compared to controls. Ischemia caused a significant decline in heart function in controls and female OHM, while function in male OHM remained unchanged. Conclusions: Adult male OHM demonstrate programmed cardiac dysfunction. Given the growing number of pregnancies complicated by hyperglycemia, additional assessment of cardiac function of adults born to diabetic mothers may be warranted.

show abstract

“…Demiroren et al also demonstrate its presence in macrosomic babies with no history of maternal diabetes 14. Way et al showed this abnormality tends to normalise by the end of the first year of life 15…”

Section: Discussionmentioning

confidence: 99%