Echocardiographic Findings Predict in-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus Aureus Endocarditis: An Analysis From the International Collaboration on Endocarditis- Prospective Echo Cohort Study

Clinical utility of echocardiography for the diagnosis of native valve infective endocarditis in Staphylococcus aureus bacteremia

“…Our study cohort patients with SAB IE had poor outcomes, with approximately one‐third of the patient population dying within one year. This finding is consistent with previous estimates of mortality due to SAB IE with reported one‐year mortality rates of up to 43% worldwide, based on recently published data from the International Collaboration on Endocarditis cohort . The poor health status of patients most at risk of acquiring SAB, including individuals with diabetes mellitus, multiple comorbidities, and permanent venous catheters, likely contributes to the high mortality in this patient population .…”

“…This finding is consistent with previous estimates of mortality due to SAB IE with reported one-year mortality rates of up to 43% worldwide, based on recently published data from the International Collaboration on Endocarditis cohort. 3 The poor health status of patients most at risk of acquiring SAB, including individuals with diabetes mellitus, multiple comorbidities, and permanent venous catheters, likely contributes to the high mortality in this patient population. 19 The Kaplan-Meier curve suggests that there is no significant mortality difference at any point throughout the first year, although it suggests that a greater proportion of deaths occur earlier on in patients with IE.…”

“…Infective endocarditis (IE) complicates up to 30% of cases of Staphylococcus aureus bacteremia (SAB), with an increased mortality rate of up to 43% . While historically considered a disease of individuals with rheumatic heart disease, novel risk factors have emerged and broadened the patient population at risk for IE.…”

“…Infective endocarditis (IE) complicates up to 30% of cases of Staphylococcus aureus bacteremia (SAB), 1,2 with an increased mortality rate of up to 43%. 3 While historically considered a disease of individuals with rheumatic heart disease, novel risk factors have emerged and broadened the patient population at risk for IE. These risk factors include increasing patient age, presence of degenerative valvular heart disease, use of intravenous drugs, and the presence of foreign intra-cardiac bodies including prosthetic valves, implantable cardiac devices, and chronic hemodialysis catheters.…”

Clinical and Echocardiographic Factors Associated With In-Hospital Mortality in Patients With Infective Endocarditis Affecting the Native Tricuspid Valve

“…This may be due to several factors, including the fact that often right-sided disease stems from left-sided pathology 8 . Additionally, right-sided structures may be more difficult to visualize with echocardiography and only recently have standardized recommendations for echocardiographic assessment of the right-sided heart been available 7 intracardiac abscess and LVEF < 40% are predictors of in-hospital mortality 10 . Our findings suggest that LVEF < 40% may be a predictor in right-sided IE as well.…”