Echocardiographic findings in systemic lupus erythematosus and its relation to disease activity and damage index

Mohammed, Maha A.; Rady, Shaimaa A.K.; Mokadem, Mostafa El; Fadda, Samia H.

doi:10.1016/j.ejr.2017.10.009

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…Twenty-two (22) studies published between 1995 and 2019 investigating autoimmune diseases with cardiac involvement were included in the present review . The studies consisted of fifteen (15) prospective studies [223,[226][227][228][229][231][232][233][234][235][236][237]239,240,243], six (6) cross-sectional studies [225,230,238,241,242,244] and one (1) retrospective study [224] (Table 1). In total, the 22 studies enrolled 4,385 patients comprising of a greater majority of women (n = 3,195; 73%) and mean age 43 years range 26-59.…”

Section: Resultsmentioning

confidence: 99%

“…The mean duration of the disease was 10.18 years, range 4.1 to 24.3 years. The most common diagnostic test used in 13 studies each were ECG [223][224][225][226][227][228][229][230][231][232][233]235,241] and echocardiography [224,231,[234][235][236][237][238][239][240][241][242][243][244], and less commonly chest x-ray in used in two studies [235,241].…”

Section: Resultsmentioning

confidence: 99%

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autoimmune-cardiomyopathy-a-review-and-pooled-analysis-of-pathophysiology-diagnosis-and-clinical-management

Albakri¹

2019

Med Clin Arch

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Dilated cardiomyopathy (DCM), characterized by dilatation of cardiac chambers and systolic dysfunction, is one of the leading causes of severe heart failure (HF) and the most common indication for heart transplantation. Despite significant therapeutic improvements, its incidence and mortality is persistently high largely attributable to heterogeneous aetiology. Infectious diseases and genetic factors predominate research on the causes of DCM. However, evidence over the past two decades reveal distinct autoantibodies or other immune factors in heterogeneous subsets of DCM suggesting the involvement of autoimmune mechanisms in the pathogenesis of DCM. Hitherto, accumulated evidence demonstrates abnormalities in cell-mediated immunity such as altered lymphocyte function and relative proportion of lymphocytes subsets, activated cytokine system, inappropriate expression of histocompatibility complex on cardiac tissue and the expression of adhesion molecules on cardiomyocytes. This evidence suggest a subset of DCM patients is autoimmunity-mediated. This review aims to summarize the contemporary understanding of the characteristics of autoimmune cardiomyopathy in humans, proposed pathophysiology mechanisms as well as the ongoing clinical investigations that have focused on autoimmunity as a target for therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

autoimmune-cardiomyopathy-a-review-and-pooled-analysis-of-pathophysiology-diagnosis-and-clinical-management

Albakri¹

2019

Med Clin Arch

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“…The study by Mukerjee et al found that the EPASP on echo (mmHg) was 39 ± 15 in scleroderma patients without lung fibrosis and 46 ± 18 in scleroderma patients with lung fibrosis detected by HRCT [ 36 ]. In the study of Mohammed et al , the mean EPASP in the studied SLE patients was 31 ± 5.1 mmHg with no significant variation between the diseased and control group [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of cardiopulmonary manifestations and its correlation with semi-quantitative scoring of high-resolution computed tomography in patients with autoimmune rheumatic diseases

et al. 2023

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Purpose Autoimmune rheumatic diseases (ARD) are groups of diseases that are commonly associated with cardiac and pulmonary manifestations and may affect the morbidity and mortality of the patients. The study aimed to the assessment of cardiopulmonary manifestations and their correlation with the semi-quantitative scoring of high-resolution computed tomography (HRCT) in ARD patients. Methods and patients 30 patients with ARD were included in the study (mean age 42.2 ± 9.76 years) [10 patients were scleroderma (SSc), 10 patients were rheumatoid arthritis (RA), and 10 patients were systemic lupus erythematosus (SLE)]. They all met the diagnostic criteria of the American College of Rheumatology and underwent spirometry, echocardiography, and chest HRCT. The HRCT was assessed by a semi-quantitative score for parenchymal abnormalities. Correlation between HRCT lung scores and: inflammatory markers, lung volumes in spirometry, and echocardiographic indices has been performed. Results The total lung score (TLS) by HRCT was 14.8 ± 8.78 (mean ± SD), ground glass opacity score (GGO) was 7.20 ± 5.79 (mean ± SD) and fibrosis lung score (F) was 7.63 ± 6.05 (mean ± SD). TLS correlated significantly with ESR (r 0.528, p 0.003), CRP (r 0.439, p 0.015), PaO2 (r -0.395, P 0.031) FVC% (r -0.687, p 0.001), and echocardiographic Tricuspid E (r -0.370, p 0.044), Tricuspid E/è (r -0.397,p 0.03), ESPAP (r 0.459,p 0.011), TAPSE (r -0.405, p 0.027), MPI-TDI (r -0.428, p 0.018) and RV Global strain(r -0.567, p 0.001). GGO score correlated significantly with ESR (r 0.597, p 0.001), CRP (r 0.473, p 0.008), FVC% (r -0.558, p 0.001), and RV Global strain(r -0.496, p 0.005). F score correlated significantly with FVC% (r -0.397, p 0.030), Tricuspid E/è (r -0.445, p 0.014), ESPAP (r 0.402, p 0.028), and MPI-TDI (r -0.448, p 0.013). Conclusion The total lung score and GGO score in ARD were found to be consistently significantly correlated with FVC% predicted, PaO2, inflammatory markers, and RV functions. Fibrotic score correlated with ESPAP. Therefore, in a clinical setting, most clinicians who monitor patients suffering from ARD should concern with the applicability of semiquantitative HRCT scoring in clinical practice.

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“…[52] In the study of Mohammed et al, the mean EPASP in the studied SLE patients was 31 ± 5.1 mmHg with no signi cant difference between the diseased and control group. [53] These variations may be due to the different groups studied.…”

Section: Discussionmentioning

confidence: 99%

“…[64] In studies done on SLE patients, it was found no signi cant correlation between PAP and SLEDAI. [53,65] We can explain these variations by the small number of patients in each group that need to be more evaluated by increasing the studying participants.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Cardiopulmonary Manifestations and its Correlation with Semi-quantitative scoring of High-resolution Computed Tomography in Patients with Autoimmune Rheumatic Diseases.

El-Kalashy

Elbeltagy

Zahran

et al. 2022

Preprint

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Purpose: Autoimmune rheumatic diseases (ARD) are groups of diseases that are commonly associated with cardiac and pulmonary manifestations and may affect the morbidity and mortality of the patients. This study aimed to the assessment of cardiopulmonary manifestations and its correlation with the semi-quantitative scoring of high-resolution computed tomography (HRCT) in ARD patients.Methods and patients: The study included 30 patients (mean age 42.2±9.76 years) diagnosed with ARD [10 patients were scleroderma (SSc), 10 patients were rheumatoid arthritis (RA), and 10 patients were systemic lupus erythematosus (SLE)]. All patients fulfilled the diagnostic criteria of the American College of Rheumatology and underwent spirometry, echocardiography, disease activity or disability scores, and chest HRCT. The HRCT was assessed by a semi-quantitative score for parenchymal abnormalities including ground glass opacity (GGO), fibrosis (F), and honeycombing (HC).Results: The total lung score by HRCT was 14.8±8.78 (mean±SD). There were statistically significant positive correlations between ESR (r =0.528, p=0.003), CRP (r=0.439, p =0.015) and ESPAP (r=0.459,p=0.011) and total lung score and significant negative correlation between PaO2 (r=-0.395, P=0.031), FVC% (r=-0.687, p=0.001), Tricuspid E(r= -0.370, p=0.044), Tricuspid E/è (r= -0.397,p=0.03), TAPSE (r= -0.405, p=0.027), MPI-TDI(r= -0.428, p=0.018) and RV Global strain(r= -0.567, p=0.001) and total lung score. There was no significant correlation between the total lung score and any of the disease scores.Conclusion: The semi-quantitative score is a reliable method that correlated with lung and RV functions.

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Echocardiographic findings in systemic lupus erythematosus and its relation to disease activity and damage index

Cited by 10 publications

References 32 publications

autoimmune-cardiomyopathy-a-review-and-pooled-analysis-of-pathophysiology-diagnosis-and-clinical-management

autoimmune-cardiomyopathy-a-review-and-pooled-analysis-of-pathophysiology-diagnosis-and-clinical-management

Assessment of cardiopulmonary manifestations and its correlation with semi-quantitative scoring of high-resolution computed tomography in patients with autoimmune rheumatic diseases

Assessment of Cardiopulmonary Manifestations and its Correlation with Semi-quantitative scoring of High-resolution Computed Tomography in Patients with Autoimmune Rheumatic Diseases.

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