Echocardiographic evaluation of left ventricular end diastolic pressure in patients with diastolic heart failure

Zhang, Fen; Liang, Yi; Chen, Xinxin; Xu, Liang; Zhou, Cuicui; Fan, Tingpan; Yan, Jinchaun

doi:10.1097/md.0000000000022683

Cited by 7 publications

(7 citation statements)

References 26 publications

(6 reference statements)

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“…Among them, the main judgment indexes of DHF determined by Doppler ultrasound include E /Ea > 8, LVEDP > 15 mmHg, and LVEF > 50%. The results of other studies showed that the decrease of LVEDD, Vp, and LVEF was the factor of DHF produced [ 18 , 19 ]. Other studies have shown that Vp < 45 cm/s is the left ventricular diastolic dysfunction [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

Chen

Zhou

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. To investigate the significance of echocardiography combined with N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels in the evaluation and prognosis of diastolic heart failure (DHF). Methods. Clinical data were collected from 168 patients with DHF. Serum levels of NT-pro BNP were first measured by ELISA. Meanwhile, the echocardiography was used to examine left ventricular end-diastolic diameter (LVEDD), left ventricular diameter (LVD), and other parameters. Multivariate logistic regression analysis was performed for variables in heart failure assessment grade or poor prognosis. Finally, the predictive ability for New York Heart Association (NYHA) class as well as prognosis was assessed by ROC curves. Results. NT-pro BNP was the overexpression in the serum of patients with DHF. And the degree of elevation was related to NYHA class, while NT-pro BNP levels were significantly higher in the P-MACE group than in the N-MACE group. According to the multivariate logistic regression analysis, the ratio of peak velocity of left atrial early diastolic blood flow to early diastolic peak velocity of mitral annulus ( E /Ea) and serum NT-pro BNP level was risk factors for NYHA class and prognosis. However, LVEF, LVEDD, and flow propagation velocity (Vp) can be a benefit condition. In addition, ROC curve showed that echocardiography combined with NT-pro BNP content had higher accuracy in NYHA class and prognostic assessment of DHF than applied separately. Conclusions. The diagnosis of echocardiography combined with NT-pro BNP levels has the potential to distinguish the NYHA class in heart function of patients with DHF and determine the prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

Chen

Zhou

et al. 2022

Computational and Mathematical Methods in Medicine

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“…6 Therefore, it is of great significance to evaluate the left ventricular diastolic function of patients with APE in clinical practice. At present, studies have confirmed that echocardiography can effectively evaluate the left ventricular diastolic function of patients with metabolic syndrome, 7 diastolic heart failure, healthy adults, 8 etc. However, there are few studies on its evaluation of left ventricular diastolic function in APE patients, which deserves further study.…”

Section: Introductionmentioning

confidence: 84%

Clinical application value of echocardiography in evaluating left ventricular diastolic function in patients with acute pulmonary embolism

et al. 2022

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Objective To explore the clinical value of echocardiography in the assessment of left ventricular diastolic function in patients with acute pulmonary embolism (APE). Methods APE patients in our hospital from June 2019 to June 2021 were selected as the observation group. They were divided into low-risk group (19 cases), medium-risk group (16 cases) and high-risk group (15 cases). The non-APE people in our hospital during the same period were selected as the control group. All subjects underwent echocardiography to observe the performance of APE patients under echocardiography. The peak velocity ratio S-wave/D-wave (S/D), early diastolic annular velocity/advanced diastolic annular velocity (Ea/Aa), early filling/early diastolic annular velocity (E/Ea), and early filling/early diastolic annular velocity (E/Ea) were compared with Ar and Vp, respectively; receiver operator characteristic (ROC) curve was used to evaluate the value of echocardiography in evaluating left ventricular diastolic function in patients with APE. Results Echocardiography show different manifestations of APE patients. Compared with the control group, S/D, Ea/Aa, and Vp in the observation group were significantly decreased and E/Ea and Ar in the observation group were significantly increased ( p < 0.05). With the increase of risk stratification, S/D, Ea/Aa, and Vp gradually decreased, E/Ea and Ar gradually increased, and the difference was statistically significant ( p < 0.05). The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, area under curve (AUC), and 95% CI were 89.52%, 65.57%, 72.86%, 80.82%, 75.38%, 0.730, and 0.629–0.831, respectively. Conclusion Echocardiography can effectively evaluate left ventricular diastolic function in patients with APE, and there are significant differences in left ventricular diastolic function in different risk stratification, which has important reference value for clinical diagnosis and treatment of APE.

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“…Patel et al [ 17 ] showed that the area under the ROC curve for parameters PFR, TPF, and 1/3FR measured by Myocardial Perfusion Imaging was 0.83, 0.75, and 0.80 for detecting LVEDP ≥ 18 mmHg, respectively, and that PFR, TPF, and 1/3FR were moderately correlated with LVEDP ( r = − 0.53, 0.45, − 0.45, P < 0.01). Zhang Fen et al [ 18 ]showed that good accuracy of LAVI, peak TR velocity, lateral e′, average e′, septal E/e′, and average E/e′ in diagnosing LVEDP elevation (AUC between 0.7 and 0.9). Previous studies have applied two examination methods to compare and evaluate LV systolic or diastolic function.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients

Liu

Zhou

et al. 2023

BMC Cardiovasc Disord

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Background In recent years, heart failure with preserved ejection fraction (HFpEF) has received increasing clinical attention. To investigate the diagnostic value of diastolic function parameters derived from planar gated blood-pool imaging (MUGA) for detecting HFpEF in coronary atherosclerotic heart disease (coronary artery disease, CAD) patients. Methods Ninety-seven CAD patients with left ventricular ejection fraction ≥ 50% were included in the study. Based on the left ventricular end-diastolic pressure (LVEDP), the patients were divided into the HFpEF group (LVEDP ≥ 16 mmHg, 47 cases) and the normal LV diastolic function group (LVEDP < 16 mmHg, 50 cases). Diastolic function parameters obtained by planar MUGA include peak filling rate (PFR), filling fraction during the first third of diastole (1/3FF), filling rate during the first third of diastole (1/3FR), mean filling rate during diastole (MFR), and peak filling time (TPF). Echocardiographic parameters include left atrial volume index (LAVI), peak tricuspid regurgitation velocity (peak TR velocity), transmitral diastolic early peak inflow velocity (E), average early diastolic velocities of mitral annulars (average e′), average E/e′ ratio. The diastolic function parameters obtained by planar MUGA were compared with those obtained by echocardiography to explore the clinical value of planar MUGA for detecting HFpEF. Results The Receiver-operating characteristic curve analysis of diastolic function parameters obtained from planar MUGA and echocardiography to detect HFpEF showed that: among the parameters examined by planar MUGA, the area under the curve (AUC) of PFR, 1/3FF, 1/3FR, MFR and TPF were 0.827, 0.662, 0.653, 0.663 and 0.809, respectively. Among the echocardiographic parameters, the AUCs for average e′, average E/e′ ratio, peak TR velocity, and LAVI values were 0.747, 0.706, 0.735, and 0.633. The combination of PFR and TPF showed an AUC of 0.856. PFR combined with TPF value demonstrated better predictive value than average e′ (Z = 2.020, P = 0.043). Conclusion Diastolic function parameters obtained by planar MUGA can be used to diagnose HFpEF in CAD patients. PFR combined with TPF was superior to the parameters obtained by echocardiography and showed good sensitivity and predictive power for detecting HFpEF.

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Echocardiographic evaluation of left ventricular end diastolic pressure in patients with diastolic heart failure

Cited by 7 publications

References 26 publications

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

Clinical application value of echocardiography in evaluating left ventricular diastolic function in patients with acute pulmonary embolism

Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients

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